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Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.

Publication ,  Journal Article
Morrisett, RA; Martin, D; Wilson, WA; Savage, DD; Swartzwelder, HS
Published in: Alcohol
1989

Morphological, neurochemical, and electrophysiological studies suggest that the hippocampal formation is one of the brain regions most sensitive to the teratological consequences of prenatal exposure to ethanol. We now report that prenatal ethanol exposure results in a reduction in the sensitivity of the hippocampi of adult offspring to N-methyl-D-aspartate (NMDA). Moreover, it appears that reduced sensitivity to NMDA results from abnormal magnesium regulation of the NMDA receptor-channel complex. These deficits in hippocampal function may underlie some of the behavioral and learning deficits which are characteristic of the offspring of mothers that consume even moderate amounts of ethanol during pregnancy.

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Published In

Alcohol

DOI

ISSN

0741-8329

Publication Date

1989

Volume

6

Issue

5

Start / End Page

415 / 420

Location

United States

Related Subject Headings

  • Substance Abuse
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Osmolar Concentration
  • Neurons
  • N-Methylaspartate
  • Magnesium
  • Hippocampus
  • Female
 

Citation

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Morrisett, R. A., Martin, D., Wilson, W. A., Savage, D. D., & Swartzwelder, H. S. (1989). Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate. Alcohol, 6(5), 415–420. https://doi.org/10.1016/0741-8329(89)90013-x
Morrisett, R. A., D. Martin, W. A. Wilson, D. D. Savage, and H. S. Swartzwelder. “Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.Alcohol 6, no. 5 (1989): 415–20. https://doi.org/10.1016/0741-8329(89)90013-x.
Morrisett RA, Martin D, Wilson WA, Savage DD, Swartzwelder HS. Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate. Alcohol. 1989;6(5):415–20.
Morrisett, R. A., et al. “Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.Alcohol, vol. 6, no. 5, 1989, pp. 415–20. Pubmed, doi:10.1016/0741-8329(89)90013-x.
Morrisett RA, Martin D, Wilson WA, Savage DD, Swartzwelder HS. Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate. Alcohol. 1989;6(5):415–420.
Journal cover image

Published In

Alcohol

DOI

ISSN

0741-8329

Publication Date

1989

Volume

6

Issue

5

Start / End Page

415 / 420

Location

United States

Related Subject Headings

  • Substance Abuse
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Osmolar Concentration
  • Neurons
  • N-Methylaspartate
  • Magnesium
  • Hippocampus
  • Female