Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat.

Journal Article (Journal Article)

Prenatal exposure to ethanol has been associated with birth defects ranging in severity from physical dysmorphias and profound mental retardation to more subtle compromises of cognitive and behavioral function. Recent evidence has shown the hippocampus to be damaged both morphologically and neurochemically after such exposure in experimental animals. The functional implications of these changes have just recently begun to be addressed. We now report that long-term potentiation and potassium-induced excitability are decreased in hippocampal slices from adult animals exposed to ethanol in-utero. These deficits reflect a decrease in the plasticity of the hippocampal formation. This alteration may be one factor contributing to the memory and learning deficits associated with in-utero exposure to ethanol.

Full Text

Duke Authors

Cited Authors

  • Swartzwelder, HS; Farr, KL; Wilson, WA; Savage, DD

Published Date

  • March 1988

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 121 - 124

PubMed ID

  • 3395460

International Standard Serial Number (ISSN)

  • 0741-8329

Digital Object Identifier (DOI)

  • 10.1016/0741-8329(88)90008-0


  • eng

Conference Location

  • United States