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Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat.

Publication ,  Journal Article
Swartzwelder, HS; Farr, KL; Wilson, WA; Savage, DD
Published in: Alcohol
1988

Prenatal exposure to ethanol has been associated with birth defects ranging in severity from physical dysmorphias and profound mental retardation to more subtle compromises of cognitive and behavioral function. Recent evidence has shown the hippocampus to be damaged both morphologically and neurochemically after such exposure in experimental animals. The functional implications of these changes have just recently begun to be addressed. We now report that long-term potentiation and potassium-induced excitability are decreased in hippocampal slices from adult animals exposed to ethanol in-utero. These deficits reflect a decrease in the plasticity of the hippocampal formation. This alteration may be one factor contributing to the memory and learning deficits associated with in-utero exposure to ethanol.

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Published In

Alcohol

DOI

ISSN

0741-8329

Publication Date

1988

Volume

5

Issue

2

Start / End Page

121 / 124

Location

United States

Related Subject Headings

  • Substance Abuse
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Potassium
  • Neuronal Plasticity
  • Hippocampus
  • Female
  • Evoked Potentials
 

Citation

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Swartzwelder, H. S., Farr, K. L., Wilson, W. A., & Savage, D. D. (1988). Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat. Alcohol, 5(2), 121–124. https://doi.org/10.1016/0741-8329(88)90008-0
Swartzwelder, H. S., K. L. Farr, W. A. Wilson, and D. D. Savage. “Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat.Alcohol 5, no. 2 (1988): 121–24. https://doi.org/10.1016/0741-8329(88)90008-0.
Swartzwelder HS, Farr KL, Wilson WA, Savage DD. Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat. Alcohol. 1988;5(2):121–4.
Swartzwelder, H. S., et al. “Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat.Alcohol, vol. 5, no. 2, 1988, pp. 121–24. Pubmed, doi:10.1016/0741-8329(88)90008-0.
Swartzwelder HS, Farr KL, Wilson WA, Savage DD. Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat. Alcohol. 1988;5(2):121–124.
Journal cover image

Published In

Alcohol

DOI

ISSN

0741-8329

Publication Date

1988

Volume

5

Issue

2

Start / End Page

121 / 124

Location

United States

Related Subject Headings

  • Substance Abuse
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Potassium
  • Neuronal Plasticity
  • Hippocampus
  • Female
  • Evoked Potentials