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In vivo fluorescence imaging: a personal perspective.

Publication ,  Journal Article
Ghoroghchian, PP; Therien, MJ; Hammer, DA
Published in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
March 2009

In vivo fluorescence imaging with near-infrared (NIR) light holds enormous potential for a wide variety of molecular diagnostic and therapeutic applications. Because of its quantitative sensitivity, inherent biological safety, and relative ease of use (i.e., with respect to cost, time, mobility, and its familiarity to a diverse population of investigators), fluorescence-based imaging techniques are being increasingly utilized in small-animal research. Moreover, there is substantial interest in the translation of novel optical techniques into the clinic, where they will prospectively aid in noninvasive and quantitative screening, disease diagnosis, and post-treatment monitoring of patients. Effective deep-tissue fluorescence imaging requires the application of exogenous NIR-emissive contrast agents. Currently, available probes fall into two major categories: organic and inorganic NIR fluorophores (NIRFs). In the studies reviewed herein, we utilized polymersomes (50 nm to 50 microm diameter polymer vesicles) for the incorporation and delivery of large numbers of highly emissive oligo (porphyrin)-based, organic NIRFs.

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Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

March 2009

Volume

1

Issue

2

Start / End Page

156 / 167

Related Subject Headings

  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Molecular Probe Techniques
  • Microscopy, Fluorescence
  • Fluorescent Dyes
  • Drug Carriers
  • Contrast Media
  • 4018 Nanotechnology
  • 3404 Medicinal and biomolecular chemistry
  • 3206 Medical biotechnology
 

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Ghoroghchian, P. P., Therien, M. J., & Hammer, D. A. (2009). In vivo fluorescence imaging: a personal perspective. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 1(2), 156–167. https://doi.org/10.1002/wnan.7
Ghoroghchian, P Peter, Michael J. Therien, and Daniel A. Hammer. “In vivo fluorescence imaging: a personal perspective.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 1, no. 2 (March 2009): 156–67. https://doi.org/10.1002/wnan.7.
Ghoroghchian PP, Therien MJ, Hammer DA. In vivo fluorescence imaging: a personal perspective. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2009 Mar;1(2):156–67.
Ghoroghchian, P. Peter, et al. “In vivo fluorescence imaging: a personal perspective.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, vol. 1, no. 2, Mar. 2009, pp. 156–67. Epmc, doi:10.1002/wnan.7.
Ghoroghchian PP, Therien MJ, Hammer DA. In vivo fluorescence imaging: a personal perspective. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2009 Mar;1(2):156–167.
Journal cover image

Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

March 2009

Volume

1

Issue

2

Start / End Page

156 / 167

Related Subject Headings

  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Molecular Probe Techniques
  • Microscopy, Fluorescence
  • Fluorescent Dyes
  • Drug Carriers
  • Contrast Media
  • 4018 Nanotechnology
  • 3404 Medicinal and biomolecular chemistry
  • 3206 Medical biotechnology