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COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat.

Publication ,  Journal Article
Kaufman, NA; Beare, JE; Tan, AA; Vitek, MP; McKenna, SE; Hoane, MR
Published in: Behav Brain Res
December 25, 2010

COG1410, a small, novel ApoE-mimetic peptide derived from the receptor binding region of apolipoprotein E (ApoE), has been classified as anti-inflammatory in nature and improves motor, sensorimotor, and cognitive dysfunction following cortical contusion injury (CCI). In order to further examine COG1410's preclinical efficacy on cognitive recovery, the present study evaluated COG1410 following moderate fluid percussion injury (FPI). Animals were prepared with a moderate, unilateral FPI over the hippocampus. Following FPI, animals received a regimen of five doses of COG1410 or vehicle at 2 and 4h (1.0mg/kg, i.v.) followed by additional doses administered 24, 48, and 72 h (1.0mg/kg, i.p.). Prior to injury, animals were trained for 4 days (4 trials/day) in the Morris water maze (MWM) and then tested for retrograde amnesia on post-FPI day 11 and then on a working memory task on day 18. Testing for motor dysfunction on the tapered balanced beam began on day 2 post-FPI. Administration of this regimen of COG1410 significantly improved retention of memory in the retrograde amnesia test compared to vehicle post-FPI. However, COG1410 did not significantly improve acquisition of working memory in the MWM. Motor dysfunction on the tapered beam post-FPI was improved in the COG1410-treated group compared to vehicle treatment. Cortical lesion analysis revealed that the COG1410-treated animals demonstrated significantly less tissue loss compared to vehicle-treated animals. The results of this study suggest that COG1410 significantly limited the behavioral dysfunction and tissue loss associated with FPI and demonstrated continued preclinical efficacy for TBI.

Duke Scholars

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

December 25, 2010

Volume

214

Issue

2

Start / End Page

395 / 401

Location

Netherlands

Related Subject Headings

  • Recovery of Function
  • Rats, Long-Evans
  • Rats
  • Neurology & Neurosurgery
  • Memory Disorders
  • Male
  • Injections, Intravenous
  • Injections, Intraperitoneal
  • Hippocampus
  • Drug Administration Schedule
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kaufman, N. A., Beare, J. E., Tan, A. A., Vitek, M. P., McKenna, S. E., & Hoane, M. R. (2010). COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res, 214(2), 395–401. https://doi.org/10.1016/j.bbr.2010.06.017
Kaufman, Nicholas A., Jason E. Beare, Arlene A. Tan, Michael P. Vitek, Suzanne E. McKenna, and Michael R. Hoane. “COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat.Behav Brain Res 214, no. 2 (December 25, 2010): 395–401. https://doi.org/10.1016/j.bbr.2010.06.017.
Kaufman NA, Beare JE, Tan AA, Vitek MP, McKenna SE, Hoane MR. COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res. 2010 Dec 25;214(2):395–401.
Kaufman, Nicholas A., et al. “COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat.Behav Brain Res, vol. 214, no. 2, Dec. 2010, pp. 395–401. Pubmed, doi:10.1016/j.bbr.2010.06.017.
Kaufman NA, Beare JE, Tan AA, Vitek MP, McKenna SE, Hoane MR. COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res. 2010 Dec 25;214(2):395–401.
Journal cover image

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

December 25, 2010

Volume

214

Issue

2

Start / End Page

395 / 401

Location

Netherlands

Related Subject Headings

  • Recovery of Function
  • Rats, Long-Evans
  • Rats
  • Neurology & Neurosurgery
  • Memory Disorders
  • Male
  • Injections, Intravenous
  • Injections, Intraperitoneal
  • Hippocampus
  • Drug Administration Schedule