In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences.

Published

Journal Article

Brown adipose tissue and white adipose tissue depots are noninvasively characterized in vitro and in vivo in healthy and obese mice using intermolecular zero-quantum coherence transitions between lipid and water spins. Intermolecular zero-quantum coherences enable selective detection of spatial correlation between water and lipid spins and thereby the hydration of fatty deposits with subvoxel resolution. At about a 100 mm distance scale, the major observed peaks are between water, methylene protons at 1.3 ppm, and olefinic protons at 5.3 ppm. Our in vitro results show that the methylene-olefinic intermolecular zero-quantum coherence signal is strong both in brown and white adipose tissues, but that the water-methylene intermolecular zero-quantum coherence signal is characteristic only of brown adipose tissue. In vivo, the ratio of these peaks is substantially higher in lean or young mice than in old or obese mice.

Full Text

Duke Authors

Cited Authors

  • Branca, RT; Warren, WS

Published Date

  • February 2011

Published In

Volume / Issue

  • 65 / 2

Start / End Page

  • 313 - 319

PubMed ID

  • 20939093

Pubmed Central ID

  • 20939093

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.22622

Language

  • eng