Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo.

Published

Journal Article

Until recently, NMR imaging with intermolecular multiple-quantum coherences (iMQCs) has been based on the acquisition of a single echo. In vivo studies of iMQC image contrast would greatly benefit from a method that could acquire several orders of quantum coherence during the same acquisition. This would enable comparison of the image contrast for various orders and eliminate image coregistration problems between scans. It has previously been demonstrated that multiple orders of iMQC images can be simultaneously acquired of a simple phantom. Here, we examine the technique and its effect on biological tissue, both in vivo and in vitro. First, we establish the effectiveness of the iMQC sequence in vivo using earthworms as specimens. We then further show that the multi-CRAZED sequence enhances detection of next generation (nanoparticle) contrast agents on excised tumor tissue.

Full Text

Duke Authors

Cited Authors

  • Shannon, KL; Branca, RT; Galiana, G; Cenzano, S; Bouchard, L-S; Soboyejo, W; Warren, WS

Published Date

  • December 2004

Published In

Volume / Issue

  • 22 / 10

Start / End Page

  • 1407 - 1412

PubMed ID

  • 15707790

Pubmed Central ID

  • 15707790

Electronic International Standard Serial Number (EISSN)

  • 1873-5894

International Standard Serial Number (ISSN)

  • 0730-725X

Digital Object Identifier (DOI)

  • 10.1016/j.mri.2004.10.019

Language

  • eng