Caffeine augmentation of ECT.


Journal Article

In a randomized, double-blind, placebo-controlled pilot study of 40 depressed inpatients, the authors compared two techniques for maintaining seizure duration during pulse unilateral ECT: pretreatment with intravenous caffeine versus electrical stimulus intensity dosing. Both techniques effectively maintained seizure duration, but with caffeine this was accomplished without any increase in mean stimulus intensity over the course of ECT. There were no differences between the two techniques in therapeutic outcome or cognitive side effects from ECT, and caffeine pretreatment was well tolerated. The authors discuss the clinical and research implications of these findings with respect to strategies for maintaining seizure duration during ECT.

Full Text

Duke Authors

Cited Authors

  • Coffey, CE; Figiel, GS; Weiner, RD; Saunders, WB

Published Date

  • May 1990

Published In

Volume / Issue

  • 147 / 5

Start / End Page

  • 579 - 585

PubMed ID

  • 2183632

Pubmed Central ID

  • 2183632

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.147.5.579


  • eng

Conference Location

  • United States