White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly.


Journal Article

In a prospective study of depressed elderly patients referred for electroconvulsive therapy (ECT), subcortical white matter hyperintensity (WMH) was seen in all 51 patients 60 years or older who received magnetic resonance imaging (MRI) prior to treatment. In over half of the patients the WMH was formally rated as at least moderately severe, and it was commonly associated with other structural brain changes. The majority (80%) of patients had late-age-onset depression, suggesting that structural brain changes may interact with aging to facilitate the emergency of depression in late life.

Full Text

Duke Authors

Cited Authors

  • Coffey, CE; Figiel, GS; Djang, WT; Saunders, WB; Weiner, RD

Published Date

  • 1989

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 135 - 144

PubMed ID

  • 2521054

Pubmed Central ID

  • 2521054

International Standard Serial Number (ISSN)

  • 0895-0172

Digital Object Identifier (DOI)

  • 10.1176/jnp.1.2.135


  • eng

Conference Location

  • United States