Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.

Journal Article (Journal Article)

Female transgenic FVB/N mice carrying the breast cancer gene HER-2/neu received epithalon (Ala-Glu-Asp-Gly) in a dose of 1 mg subcutaneously 5 times a week to from the 2nd month of life to death. Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. The peptide prolonged the average lifetime of animals without neoplasms (by 34.2%, p<0.05). Epithalon decelerated the development of age-related disturbances in reproductive activity and suppressed the formation of neoplasms. The peptide decreased the incidence of breast adenocarcinomas, lungs metastases (by 1.6 times, p<0.05), and multiple tumors (by 2 times). Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). These results indicate that Epithalon possesses geroprotective activity and inhibits breast carcinogenesis in transgenic mice, which is probably related to suppression of HER-2/neu expression.

Full Text

Duke Authors

Cited Authors

  • Anisimov, VN; Khavinson, VK; Alimova, IN; Semchenko, AV; Yashin, AI

Published Date

  • August 2002

Published In

Volume / Issue

  • 134 / 2

Start / End Page

  • 187 - 190

PubMed ID

  • 12459848

Electronic International Standard Serial Number (EISSN)

  • 1573-8221

International Standard Serial Number (ISSN)

  • 0007-4888

Digital Object Identifier (DOI)

  • 10.1023/a:1021104819170


  • eng