Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts.


Journal Article

The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 +/- 1.74%) to that aged 40-49 years (8.51 +/- 4.07%). Then it declined reaching the minimum value in centenarians (1.58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.

Full Text

Duke Authors

Cited Authors

  • De Benedictis, G; Carotenuto, L; Carrieri, G; De Luca, M; Falcone, E; Rose, G; Yashin, AI; Bonafè, M; Franceschi, C

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 62 / Pt 2

Start / End Page

  • 115 - 122

PubMed ID

  • 9759473

Pubmed Central ID

  • 9759473

Electronic International Standard Serial Number (EISSN)

  • 1469-1809

International Standard Serial Number (ISSN)

  • 0003-4800

Digital Object Identifier (DOI)

  • 10.1046/j.1469-1809.1998.6220115.x


  • eng