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Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment.

Publication ,  Journal Article
Pretty, JR; Connor, TH; Spasojevic, I; Kurtz, KS; McLaurin, JL; B'Hymer, C; Debord, DG
Published in: J Oncol Pharm Pract
March 2012

CONTEXT: Healthcare worker exposure to antineoplastic drugs continues to be reported despite safe handling guidelines published by several groups. Sensitive sampling and analytical methods are needed so that occupational safety and health professionals may accurately assess environmental and biological exposure to these drugs in the workplace. OBJECTIVE: To develop liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analytical methods for measuring five antineoplastic drugs in samples from the work environment, and to apply these methods in validating sampling methodology. A single method for quantifying several widely used agents would decrease the number of samples required for method development, lower cost, and time of analysis. METHODS: for measuring these drugs in workers' urine would also be useful in monitoring personal exposure levels. RESULTS: LC-MS/MS methods were developed for individual analysis of five antineoplastic drugs in wipe and air sample media projected for use in field sampling: cyclophosphamide, ifosfamide, paclitaxel, doxorubicin, and 5-fluorouracil. Cyclophosphamide, ifosfamide, and paclitaxel were also measured simultaneously in some stages of the work. Extraction methods for air and wipe samples were developed and tested using the aforementioned analytical methods. Good recoveries from the candidate air and wipe sample media for most of the compounds, and variable recoveries for test wipe samples depending on the surface under study, were observed. Alternate LC-MS/MS methods were also developed to detect cyclophosphamide and paclitaxel in urine samples. CONCLUSIONS: The sampling and analytical methods were suitable for determining worker exposure to antineoplastics via surface and breathing zone contamination in projected surveys of healthcare settings.

Duke Scholars

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Published In

J Oncol Pharm Pract

DOI

EISSN

1477-092X

Publication Date

March 2012

Volume

18

Issue

1

Start / End Page

23 / 36

Location

England

Related Subject Headings

  • Workplace
  • Tandem Mass Spectrometry
  • Oncology & Carcinogenesis
  • Occupational Exposure
  • Humans
  • Guidelines as Topic
  • Equipment Contamination
  • Environmental Monitoring
  • Chromatography, High Pressure Liquid
  • Antineoplastic Agents
 

Citation

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Pretty, J. R., Connor, T. H., Spasojevic, I., Kurtz, K. S., McLaurin, J. L., B’Hymer, C., & Debord, D. G. (2012). Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment. J Oncol Pharm Pract, 18(1), 23–36. https://doi.org/10.1177/1078155210389215
Pretty, Jack R., Thomas H. Connor, Ivan Spasojevic, Kristine S. Kurtz, Jeffrey L. McLaurin, Clayton B’Hymer, and D Gayle Debord. “Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment.J Oncol Pharm Pract 18, no. 1 (March 2012): 23–36. https://doi.org/10.1177/1078155210389215.
Pretty JR, Connor TH, Spasojevic I, Kurtz KS, McLaurin JL, B’Hymer C, et al. Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment. J Oncol Pharm Pract. 2012 Mar;18(1):23–36.
Pretty, Jack R., et al. “Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment.J Oncol Pharm Pract, vol. 18, no. 1, Mar. 2012, pp. 23–36. Pubmed, doi:10.1177/1078155210389215.
Pretty JR, Connor TH, Spasojevic I, Kurtz KS, McLaurin JL, B’Hymer C, Debord DG. Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment. J Oncol Pharm Pract. 2012 Mar;18(1):23–36.
Journal cover image

Published In

J Oncol Pharm Pract

DOI

EISSN

1477-092X

Publication Date

March 2012

Volume

18

Issue

1

Start / End Page

23 / 36

Location

England

Related Subject Headings

  • Workplace
  • Tandem Mass Spectrometry
  • Oncology & Carcinogenesis
  • Occupational Exposure
  • Humans
  • Guidelines as Topic
  • Equipment Contamination
  • Environmental Monitoring
  • Chromatography, High Pressure Liquid
  • Antineoplastic Agents