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Ivan Spasojevic

Associate Professor in Medicine
Medicine, Medical Oncology
Box 3839 Med Ctr, Durham, NC 27710
5317 Orange Zone, Duke Hospital South, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor in Medicine · 2021 - Present Medicine, Medical Oncology, Medicine
Member of the Duke Cancer Institute · 1992 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage.

Journal Article Pharmaceuticals (Basel) · April 8, 2025 Background: Manganese porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), improves neurologic deficits in experimental ischemic stroke and has the potential to serve as an adjunct with thrombolysis or thrombectomy in stroke patients. In 10-30% of stroke patients follow ... Full text Link to item Cite

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).

Journal Article Nature communications · April 2025 Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying ... Full text Cite

Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.

Journal Article Nat Commun · December 30, 2024 The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A ... Full text Link to item Cite
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Recent Grants


Boston Children's/UCLA/Duke Next Generation Regeneration for Osteoarthritis (BUD NextGenRegen for OA)

ResearchInvestigator · Awarded by Advanced Research Projects Agency for Health · 2024 - 2029

Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy

ResearchCo Investigator · Awarded by National Cancer Institute · 2024 - 2028

Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2026

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Education, Training & Certifications


Duke University · 1999 Ph.D.