Current Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage.
Journal Article Pharmaceuticals (Basel) · April 8, 2025 Background: Manganese porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), improves neurologic deficits in experimental ischemic stroke and has the potential to serve as an adjunct with thrombolysis or thrombectomy in stroke patients. In 10-30% of stroke patients follow ... Full text Link to item CiteEffective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Journal Article Nature communications · April 2025 Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying ... Full text CiteDesign of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.
Journal Article Nat Commun · December 30, 2024 The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A ... Full text Link to item CiteRecent Grants
Boston Children's/UCLA/Duke Next Generation Regeneration for Osteoarthritis (BUD NextGenRegen for OA)
ResearchInvestigator · Awarded by Advanced Research Projects Agency for Health · 2024 - 2029Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
ResearchCo Investigator · Awarded by National Cancer Institute · 2024 - 2028Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2026View All Grants
Education, Training & Certifications
Duke University ·
1999
Ph.D.