Current Duke Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
BMX-001 acts as a selective chemoradioprotector in rectal cancer.
Journal article Redox Biochem Chem · June 2026 Colorectal cancer is a common yet survivable malignancy, partly due to the addition of chemoradiation to treatment regimens. Many patients suffer treatment-related side effects such as pain, diarrhea, and myelosuppression, and increasing tolerance of treat ... Full text Link to item CiteTreatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage.
Journal article Pharmaceuticals (Basel) · April 8, 2025 Background: Manganese porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), improves neurologic deficits in experimental ischemic stroke and has the potential to serve as an adjunct with thrombolysis or thrombectomy in stroke patients. In 10-30% of stroke patients follow ... Full text Link to item CiteEffective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Journal article Nat Commun · April 2, 2025 Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying ... Full text Link to item CiteRecent Grants
Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
ResearchCo Investigator · Awarded by National Cancer Institute · 2024 - 2028Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA Metabolism
ResearchCo Investigator · Awarded by National Center for Advancing Translational Sciences · 2024 - 2027Targeting Apolipoprotein-E to Improve Recovery after Spinal Cord Injury
ResearchCollaborator · Awarded by University of Maryland, Baltimore · 2025 - 2027View All Grants
Education
Duke University ·
1999
Ph.D.