Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1999
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Medical Oncology, Medicine 2017 - 2020
  • Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2012 - 2017
• Research
• 

  Selected Grants

  • Developing non-opiate GPCR signaling biased agents for pain management awarded by Department of Defense 2022 - 2026
  • Computational Design of Antibody-Drug-Excipient Nanoparticles awarded by National Institutes of Health 2023 - 2026
  • Redox-active drug, BMX-001, as a neuroprotectant: A preventive strategy for chemotherapy induced neurotoxicity awarded by Health and Environmental Sciences Institute 2022 - 2024
  • Anti-Atherogenic Mechanisms of Drebrin awarded by National Institutes of Health 2019 - 2023
  • Human EGFRvIII-specific BiTE for the treatment of Glioblastoma awarded by National Institutes of Health 2015 - 2023
  • Reformulation of Pharmaceutical to Treat ALS awarded by North Carolina Biotechnology Center 2020 - 2022
  • Surface Contamination and PPE Use in Inpatient Oncology: The Impact of Covid-19 awarded by Centers for Disease Control and Prevention 2021 - 2022
  • Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke awarded by BioMimetix JV LLC 2019 - 2021
  • Role of GLUD2 as a metabolic driver of gliomas with IDH1 mutations awarded by National Institutes of Health 2016 - 2020
  • Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2020
  • The Role of IDH1 Mutations in Gliomagenesis and Metabolism awarded by National Institutes of Health 2009 - 2020
  • Role of Debrin in Vascular Smooth Muscle Transdifferentiation awarded by  American Heart Association 2019
  • AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
  • Development of mechanistically distinct androgen receptor antagonists and degraders for the treatment of advanced castration resistant prostate cancer awarded by Department of Defense 2015 - 2019
  • Measurement of oxidative stress biomarkers in human plasma and urine awarded by University of California - Berkeley 2016 - 2018
  • New therapeutic strategy in reversing radiation-induced erectile dysfunction with prostate cancer pa-tients awarded by North Carolina Biotechnology Center 2016 - 2017
  • Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham 2013 - 2016
  • Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome awarded by National Institutes of Health 2013 - 2015
  • Biomarker Studies for Novel Anti-Cancer Agents awarded by National Institutes of Health 2003 - 2008
• 

  External Relationships

  • BioMimetix Pharmaceutical, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ozer, Imran, Anna Slezak, Parul Sirohi, Xinghai Li, Nikita Zakharov, Yunxin Yao, Jeffrey I. Everitt, et al. “An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.” Biomaterials 294 (March 2023): 121985. https://doi.org/10.1016/j.biomaterials.2022.121985.
       Full Text  Link to Item
    • Soares, Rita B., Rita Manguinhas, João G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sérgio P. Camões, et al. “MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells.” Antioxidants (Basel) 11, no. 11 (November 7, 2022). https://doi.org/10.3390/antiox11112198.
       Full Text  Link to Item
    • Byers, Isabelle S., Nicholas A. Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojevic, Ping Fan, et al. “Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.” Antimicrob Agents Chemother 66, no. 10 (October 18, 2022): e0014022. https://doi.org/10.1128/aac.00140-22.
       Full Text  Link to Item
    • Saha, Soumen, Samagya Banskota, Jianqiao Liu, Nikita Zakharov, Michael Dzuricky, Xinghai Li, Ping Fan, et al. “Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model.” Nano Lett 22, no. 14 (July 27, 2022): 5898–5908. https://doi.org/10.1021/acs.nanolett.2c01850.
       Full Text  Link to Item
    • Wang, Peng, Ying Li, Baihui Yan, Zhong Yang, Litao Li, Zhipeng Cao, Xuan Li, et al. “Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.” Biology (Basel) 11, no. 7 (June 24, 2022). https://doi.org/10.3390/biology11070957.
       Full Text  Link to Item
    • Zhang, Tian, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Subha Bakthavatsalam, et al. “Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.” Prostate 82, no. 7 (May 2022): 858–66. https://doi.org/10.1002/pros.24329.
       Full Text  Link to Item
    • Zhou, Qingyu, Justin Doherty, Antonina Akk, Luke E. Springer, Ping Fan, Ivan Spasojevic, Ganesh V. Halade, et al. “Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury.” Nanomaterials (Basel) 12, no. 3 (January 21, 2022). https://doi.org/10.3390/nano12030336.
       Full Text  Link to Item
    • Chaiswing, Luksana, Chontida Yarana, William St Clair, Artak Tovmasyan, Ines Batinic-Haberle, Ivan Spasojevic, and Daret St Clair. “A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line.” Oxid Med Cell Longev 2022 (2022): 9664636. https://doi.org/10.1155/2022/9664636.
       Full Text  Link to Item
    • Nicholls, P. J., Thomas F. Pack, Nikhil M. Urs, Sunil Kumar, Yang Zhou, Gabriel Ichim, Joshua D. Ginzel, et al. “Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice.” Eneuro 9, no. 5 (2022). https://doi.org/10.1523/ENEURO.0147-21.2022.
       Full Text  Link to Item
    • Osada, Takuya, Erika J. Crosby, Kensuke Kaneko, Joshua C. Snyder, Joshua D. Ginzel, Chaitanya R. Acharya, Xiao-Yi Yang, et al. “HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.” Mol Cancer Ther 21, no. 1 (January 2022): 217–26. https://doi.org/10.1158/1535-7163.MCT-21-0334.
       Full Text  Link to Item
    • Whitley, Melodi Javid, Jutamas Suwanpradid, Chester Lai, Simon W. Jiang, Jonathan L. Cook, Daniel E. Zelac, Ross Rudolph, et al. “ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.” J Invest Dermatol 141, no. 10 (October 2021): 2509–20. https://doi.org/10.1016/j.jid.2021.02.753.
       Full Text  Link to Item
    • Hoover, Sarah E., Dora Il’yasova, Kevin R. Fontaine, Ivan Spasojevic, Barbara A. Gower, and Amy M. Goss. “A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F2-Isoprostanes in Older Adults Exposed to a Diet Intervention.” Curr Dev Nutr 5, no. 6 (June 2021): nzab082. https://doi.org/10.1093/cdn/nzab082.
       Full Text  Link to Item
    • Wang, Zhuoran, Xuan Li, Ivan Spasojevic, Liping Lu, Yuntian Shen, Xingguang Qu, Ulrike Hoffmann, et al. “Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.” Exp Neurol 339 (May 2021): 113646. https://doi.org/10.1016/j.expneurol.2021.113646.
       Full Text  Open Access Copy  Link to Item
    • Boss, Mary-Keara, Rebecca E. Oberley-Deegan, Ines Batinic-Haberle, Geoffrey A. Talmon, Jason A. Somarelli, Shengnan Xu, Elizabeth A. Kosmacek, et al. “Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.” Radiat Res 195, no. 2 (February 1, 2021): 128–39. https://doi.org/10.1667/RADE-20-00109.1.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, and Angeles Alvarez Secord. “H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.” Oxid Med Cell Longev 2021 (2021): 6653790. https://doi.org/10.1155/2021/6653790.
       Full Text  Open Access Copy  Link to Item
    • Reddy, Gireesh B., David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham, and William C. Eward. “Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.” Molecular Cancer Therapeutics 19, no. 7 (July 2020): 1448–61. https://doi.org/10.1158/1535-7163.mct-19-0689.
       Full Text  Open Access Copy
    • Chagoya, Gustavo, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, et al. “Efficacy of osimertinib against EGFRvIII+ glioblastoma.” Oncotarget 11, no. 22 (June 2, 2020): 2074–82. https://doi.org/10.18632/oncotarget.27599.
       Full Text  Link to Item
    • Li, Litao, Artak Tovmasyan, Huaxin Sheng, Bin Xu, Romulo S. Sampaio, Julio S. Reboucas, David S. Warner, Ines Batinic-Haberle, and Ivan Spasojevic. “Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+.” Antioxidants (Basel) 9, no. 6 (June 1, 2020). https://doi.org/10.3390/antiox9060467.
       Full Text  Open Access Copy  Link to Item
    • Walton, AnnMarie, Margaret A. Bush, Christian Douglas, Deborah H. Allen, Martha Polovich, and Ivan Spasojevic. “Surface Contamination With Antineoplastic Drugs on Two Inpatient Oncology Units.” Oncol Nurs Forum 47, no. 3 (May 1, 2020): 263–72. https://doi.org/10.1188/20.ONF.263-272.
       Full Text  Link to Item
    • Banskota, Samagya, Soumen Saha, Jayanta Bhattacharya, Nadia Kirmani, Parisa Yousefpour, Michael Dzuricky, Nikita Zakharov, et al. “Genetically Encoded Stealth Nanoparticles of a Zwitterionic Polypeptide-Paclitaxel Conjugate Have a Wider Therapeutic Window than Abraxane in Multiple Tumor Models.” Nano Lett 20, no. 4 (April 8, 2020): 2396–2409. https://doi.org/10.1021/acs.nanolett.9b05094.
       Full Text  Link to Item
    • Schaller, Teilo H., David J. Snyder, Ivan Spasojevic, Patrick C. Gedeon, Luis Sanchez-Perez, and John H. Sampson. “First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach.” J Immunother Cancer 8, no. 1 (April 2020). https://doi.org/10.1136/jitc-2019-000213.
       Full Text  Link to Item
    • Grimberg, Dominic C., Ankeet Shah, Wei Phin Tan, Wiguins Etienne, Ivan Spasojevic, and Brant A. Inman. “Hyperthermia Improves Solubility of Intravesical Chemotherapeutic Agents.” Bladder Cancer 6, no. 4 (2020): 461–70. https://doi.org/10.3233/BLC-200350.
       Full Text  Open Access Copy  Link to Item
    • Tan, Wei Phin, Andrew Chang, Steven C. Brousell, Dominic C. Grimberg, Joseph J. Fantony, Thomas A. Longo, Wiguins Etienne, Ivan Spasojevic, Paolo Maccarini, and Brant A. Inman. “Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study.” Int J Hyperthermia 37, no. 1 (2020): 854–60. https://doi.org/10.1080/02656736.2020.1780328.
       Full Text  Open Access Copy  Link to Item
    • Batinic-Haberle, I., and I. Spasojevic. “25 years of development of Mn porphyrins-from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA.” Journal of Porphyrins and Phthalocyanines 23, no. 11–12 (November 1, 2019): 1326–35. https://doi.org/10.1142/S1088424619300283.
       Full Text
    • Moure, Casey J., Bill H. Diplas, Lee H. Chen, Rui Yang, Christopher J. Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S. Waitkus, Yiping He, and Hai Yan. “CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.” Mol Cancer Res 17, no. 10 (October 2019): 2042–50. https://doi.org/10.1158/1541-7786.MCR-19-0309.
       Full Text  Link to Item
    • Schaller, Teilo H., Matthew W. Foster, J Will Thompson, Ivan Spasojevic, Deimante Normantaite, M Arthur Moseley, Luis Sanchez-Perez, and John H. Sampson. “Pharmacokinetic Analysis of a Novel Human EGFRvIII:CD3 Bispecific Antibody in Plasma and Whole Blood Using a High-Resolution Targeted Mass Spectrometry Approach.” J Proteome Res 18, no. 8 (August 2, 2019): 3032–41. https://doi.org/10.1021/acs.jproteome.9b00145.
       Full Text  Link to Item
    • Hansen, Landon J., Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, et al. “MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.” Cancer Res 79, no. 13 (July 1, 2019): 3383–94. https://doi.org/10.1158/0008-5472.CAN-18-1010.
       Full Text  Link to Item
    • MacKinney, Anson, Emily Woska, Ivan Spasojevic, Ines Batinic-Haberle, and Rahima Zennadi. “Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.” Redox Biol 25 (July 2019): 101097. https://doi.org/10.1016/j.redox.2019.101097.
       Full Text  Open Access Copy  Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, and Ivan Spasojevic. “Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.” Antioxid Redox Signal 29, no. 16 (December 1, 2018): 1691–1724. https://doi.org/10.1089/ars.2017.7453.
       Full Text  Link to Item
    • Tovmasyan, Artak, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, Romulo S. Sampaio, Julio S. Reboucas, Natalia Kyui, Ludmil Benov, et al. “Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.” Antioxid Redox Signal 29, no. 13 (November 1, 2018): 1196–1214. https://doi.org/10.1089/ars.2017.7218.
       Full Text  Link to Item
    • Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.” Bioorg Med Chem 26, no. 20 (November 1, 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.
       Full Text  Link to Item
    • Blueschke, Gert, Alina Boico, Ayele H. Negussie, Pavel Yarmolenko, Bradford J. Wood, Ivan Spasojevic, Ping Fan, et al. “Enhanced Drug Delivery to the Skin Using Liposomes.” Plast Reconstr Surg Glob Open 6, no. 7 (July 2018): e1739. https://doi.org/10.1097/GOX.0000000000001739.
       Full Text  Open Access Copy  Link to Item
    • Il’yasova, Dora, Luigi Fontana, Manjushri Bhapkar, Carl F. Pieper, Ivan Spasojevic, Leanne M. Redman, Sai Krupa Das, Kim M. Huffman, William E. Kraus, and William E. CALERIE Study Investigators. “Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.” Aging Cell 17, no. 2 (April 2018). https://doi.org/10.1111/acel.12719.
       Full Text  Link to Item
    • Cline, John Mark, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, et al. “Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.” Antioxidants (Basel) 7, no. 3 (March 7, 2018). https://doi.org/10.3390/antiox7030040.
       Full Text  Link to Item
    • Abaffy, Tatjana, James R. Bain, Michael J. Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara K. O’Neal, So Young Kim, and Hiroaki Matsunami. “A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.” Front Oncol 8 (2018): 162. https://doi.org/10.3389/fonc.2018.00162.
       Full Text  Open Access Copy  Link to Item
    • Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.
       Full Text  Link to Item
    • Bhattacharyya, Jayanta, Xiu-Rong Ren, Robert A. Mook, Jiangbo Wang, Ivan Spasojevic, Richard T. Premont, Xinghai Li, Ashutosh Chilkoti, and Wei Chen. “Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.” Nanoscale 9, no. 34 (August 31, 2017): 12709–17. https://doi.org/10.1039/c7nr01973d.
       Full Text  Link to Item
    • Boss, M. K., M. W. Dewhirst, R. S. Sampaio, A. Bennett, A. Tovmasyan, K. G. Berman, A. W. Beaven, et al. “Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.” Cancer Chemother Pharmacol 80, no. 2 (August 2017): 421–31. https://doi.org/10.1007/s00280-017-3372-z.
       Full Text  Link to Item
    • Leu, David, Ivan Spasojevic, Huy Nguyen, Brian Deng, Artak Tovmasyan, Tin Weitner, Romulo S. Sampaio, Ines Batinic-Haberle, and Ting-Ting Huang. “CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.” Redox Biol 12 (August 2017): 864–71. https://doi.org/10.1016/j.redox.2017.04.027.
       Full Text  Link to Item
    • Tang, X., C. -. K. Ding, J. Wu, J. Sjol, S. Wardell, I. Spasojevic, D. George, et al. “Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.” Oncogene 36, no. 30 (July 27, 2017): 4235–42. https://doi.org/10.1038/onc.2016.394.
       Full Text  Link to Item
    • Tang, X., C. -. K. Ding, J. Wu, J. Sjol, S. Wardell, I. Spasojevic, D. George, et al. “Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.” Oncogene 36, no. 30 (July 27, 2017): 4379. https://doi.org/10.1038/onc.2017.192.
       Full Text  Link to Item
    • Birer, Samuel R., Chen-Ting Lee, Kingshuk Roy Choudhury, Kenneth H. Young, Ivan Spasojevic, Ines Batinic-Haberle, James D. Crapo, Mark W. Dewhirst, and Kathleen A. Ashcraft. “Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.” Radiat Res 188, no. 1 (July 2017): 94–104. https://doi.org/10.1667/RR14757.1.S1.
       Full Text  Link to Item
    • Melton, Charles David, Ruiyan Luo, Brett J. Wong, Ivan Spasojevic, Lynne E. Wagenknecht, Ralph B. D’Agostino, and Dora Il’yasova. “Urinary F2-isoprostanes and the risk of hypertension.” Ann Epidemiol 27, no. 6 (June 2017): 391–96. https://doi.org/10.1016/j.annepidem.2017.05.005.
       Full Text  Link to Item
    • Pirozzi, Christopher J., Austin B. Carpenter, Matthew S. Waitkus, Catherine Y. Wang, Huishan Zhu, Landon J. Hansen, Lee H. Chen, et al. “Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.” Mol Cancer Res 15, no. 5 (May 2017): 507–20. https://doi.org/10.1158/1541-7786.MCR-16-0485.
       Full Text  Link to Item
    • Rajic, Zrinka, Artak Tovmasyan, Otávio L. de Santana, Isabelle N. Peixoto, Ivan Spasojevic, Silmar A. do Monte, Elizete Ventura, Júlio S. Rebouças, and Ines Batinic-Haberle. “Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.” J Inorg Biochem 169 (April 2017): 50–60. https://doi.org/10.1016/j.jinorgbio.2017.01.003.
       Full Text  Open Access Copy  Link to Item
    • Becher, Oren J., Nathan E. Millard, Shakeel Modak, Brian H. Kushner, Sofia Haque, Ivan Spasojevic, Tanya M. Trippett, et al. “A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.” Plos One 12, no. 6 (2017): e0178593. https://doi.org/10.1371/journal.pone.0178593.
       Full Text  Link to Item
    • Pollock, Julie A., Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, et al. “Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.” Nat Chem Biol 12, no. 10 (October 2016): 795–801. https://doi.org/10.1038/nchembio.2131.
       Full Text  Link to Item
    • Jacobsen, Jacob Pr, Meghan L. Rudder, Wendy Roberts, Elizabeth L. Royer, Taylor J. Robinson, Adrianna Oh, Ivan Spasojevic, Benjamin D. Sachs, and Marc G. Caron. “SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.” Neuropsychopharmacology 41, no. 9 (August 2016): 2324–34. https://doi.org/10.1038/npp.2016.35.
       Full Text  Link to Item
    • Zhang, Xiuwu, Caroline Hadley, Isabel L. Jackson, Yi Zhang, Angel Zhang, Ivan Spasojevic, Ines Batinic Haberle, and Zeljko Vujaskovic. “Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung.” Free Radic Res 50, no. 8 (August 2016): 875–86. https://doi.org/10.1080/10715762.2016.1189078.
       Full Text  Link to Item
    • Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Alina Boico, Samuel R. Birer, Kingshuk Roy Choudhury, James Herndon, et al. “Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.” Environ Mol Mutagen 57, no. 5 (June 2016): 372–81. https://doi.org/10.1002/em.22021.
       Full Text  Link to Item
    • Kanju, Patrick, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.” Sci Rep 6 (June 1, 2016): 26894. https://doi.org/10.1038/srep26894.
       Full Text  Open Access Copy  Link to Item
    • Millard, Nathan, Oren Becher, Shakeel Modak, Sofia Haque, Ivan Spasojevic, Tanya Trippett, Stephen Gilheeney, et al. “A PHASE I STUDY OF SINGLE-AGENT PERIFOSINE FOR RECURRENT/REFRACTORY PEDIATRIC CNS AND SOLID TUMORS.” Neuro Oncology 18 (June 1, 2016): 25–25.
       Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, and Ivan Spasojevic. “Opinion on Schmidt et al.” Antioxid Redox Signal 24, no. 9 (March 20, 2016): 518–24. https://doi.org/10.1089/ars.2015.6623.
       Full Text  Link to Item
    • Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
       Full Text  Link to Item
    • Batinic-Haberle, I., A. Tovmasyan, and I. Spasojevic. “Corrigendum to 'An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins - From superoxide dismutation to H2O2-driven pathways' [Redox Biology, 5C, (2015), 43-65].” Redox Biology 6 (December 1, 2015): 656. https://doi.org/10.1016/j.redox.2015.09.001.
       Full Text
    • Tovmasyan, Artak, Romulo S. Sampaio, Mary-Keara Boss, Jacqueline C. Bueno-Janice, Bader H. Bader, Milini Thomas, Julio S. Reboucas, et al. “Anticancer therapeutic potential of Mn porphyrin/ascorbate system.” Free Radic Biol Med 89 (December 2015): 1231–47. https://doi.org/10.1016/j.freeradbiomed.2015.10.416.
       Full Text  Link to Item
    • Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.
       Full Text  Open Access Copy  Link to Item
    • Mook, Robert A., Jiangbo Wang, Xiu-Rong Ren, Minyong Chen, Ivan Spasojevic, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.” Bioorg Med Chem 23, no. 17 (September 1, 2015): 5829–38. https://doi.org/10.1016/j.bmc.2015.07.001.
       Full Text  Link to Item
    • Tovmasyan, Artak, Clarissa G. C. Maia, Tin Weitner, Sebastián Carballal, Romulo S. Sampaio, Dominik Lieb, Robert Ghazaryan, et al. “A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.” Free Radic Biol Med 86 (September 2015): 308–21. https://doi.org/10.1016/j.freeradbiomed.2015.05.018.
       Full Text  Link to Item
    • Bhattacharyya, Jayanta, Joseph J. Bellucci, Isaac Weitzhandler, Jonathan R. McDaniel, Ivan Spasojevic, Xinghai Li, Chao-Chieh Lin, Jen-Tsan Ashley Chi, and Ashutosh Chilkoti. “A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.” Nat Commun 6 (August 4, 2015): 7939. https://doi.org/10.1038/ncomms8939.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, and Ivan Spasojevic. “An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.” Redox Biol 5 (August 2015): 43–65. https://doi.org/10.1016/j.redox.2015.01.017.
       Full Text  Link to Item
    • Halvorson, Kyle G., Kelly L. Barton, Kristin Schroeder, Katherine L. Misuraca, Christine Hoeman, Alex Chung, Donna M. Crabtree, et al. “A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.” Plos One 10, no. 3 (2015): e0118926. https://doi.org/10.1371/journal.pone.0118926.
       Full Text  Open Access Copy  Link to Item
    • Il’yasova, Dora, Lynne E. Wagenknecht, Ivan Spasojevic, Steven Watkins, Donald Bowden, Frances Wang, and Ralph B. D’Agostino. “Urinary F2-isoprostanes and metabolic markers of fat oxidation.” Oxid Med Cell Longev 2015 (2015): 729191. https://doi.org/10.1155/2015/729191.
       Full Text  Link to Item
    • Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.” Mol Cancer Ther 14, no. 1 (January 2015): 70–79. https://doi.org/10.1158/1535-7163.MCT-14-0343.
       Full Text  Link to Item
    • Friese, Christopher R., Cristin McArdle, Ting Zhao, Duxin Sun, Ivan Spasojevic, Martha Polovich, and Marjorie C. McCullagh. “Antineoplastic drug exposure in an ambulatory setting: a pilot study.” Cancer Nurs 38, no. 2 (2015): 111–17. https://doi.org/10.1097/NCC.0000000000000143.
       Full Text  Link to Item
    • Tovmasyan, Artak, Sebastian Carballal, Robert Ghazaryan, Lida Melikyan, Tin Weitner, Clarissa G. C. Maia, Julio S. Reboucas, et al. “Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.” Inorg Chem 53, no. 21 (November 3, 2014): 11467–83. https://doi.org/10.1021/ic501329p.
       Full Text  Link to Item
    • Tovmasyan, Artak, Nelli Babayan, David Poghosyan, Kristine Margaryan, Boris Harutyunyan, Rusanna Grigoryan, Natalia Sarkisyan, et al. “Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.” J Inorg Biochem 140 (November 2014): 94–103. https://doi.org/10.1016/j.jinorgbio.2014.06.013.
       Full Text  Link to Item
    • Tovmasyan, Artak, Sebastian Carballal, Robert Ghazaryan, Lida Melikyan, Tin Weitner, Clarissa G. C. Maia, Julio S. Reboucas, et al. “Rational Design of New Cationic Mn Porphyrins and Evaluation of Their Therapeutic Potential.” Free Radical Biology and Medicine 76 (November 2014): S94–S94. https://doi.org/10.1016/j.freeradbiomed.2014.10.326.
       Full Text
    • Yang, Phillip, David Leu, Hsun Yang, Melody Khosrav, Artak Tovmasyan, Ivan Spasojevic, Ines Batinic-Haberle, and Ting-Ting Huang. “Mitigation of Radiation-Mediated Suppression of Hippocampal Neurogenesis.” Free Radical Biology and Medicine 76 (November 2014): S97–S97. https://doi.org/10.1016/j.freeradbiomed.2014.10.335.
       Full Text
    • Reitman, Zachary J., Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao-Hua Yang, and Hai Yan. “Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.” J Biol Chem 289, no. 34 (August 22, 2014): 23318–28. https://doi.org/10.1074/jbc.M114.575183.
       Full Text  Link to Item
    • Tang, Xiaohu, Chao-Chieh Lin, Ivan Spasojevic, Edwin S. Iversen, Jen-Tsan Chi, and Jeffrey R. Marks. “A joint analysis of metabolomics and genetics of breast cancer.” Breast Cancer Res 16, no. 4 (August 5, 2014): 415. https://doi.org/10.1186/s13058-014-0415-9.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, and Ivan Spasojevic. “Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2323–25. https://doi.org/10.1089/ars.2014.5921.
       Full Text  Link to Item
    • Jumbo-Lucioni, Patricia P., Emily L. Ryan, Marquise L. Hopson, Heather M. Bishop, Tin Weitner, Artak Tovmasyan, Ivan Spasojevic, et al. “Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2361–71. https://doi.org/10.1089/ars.2012.5122.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, Emily R. H. Roberts, Zeljko Vujaskovic, Kam W. Leong, and Ivan Spasojevic. “SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2372–2415. https://doi.org/10.1089/ars.2012.5147.
       Full Text  Link to Item
    • Li, Alice Ma, Jake Martins, Artak Tovmasyan, Joan S. Valentine, Ines Batinic-Haberle, Ivan Spasojevic, and Edith B. Gralla. “Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.” Redox Biol 3 (2014): 1–6. https://doi.org/10.1016/j.redox.2014.09.003.
       Full Text  Link to Item
    • Li, Alice Ma, Jake Martins, Artak Tovmasyan, Joan S. Valentine, Ines Batinic-Haberle, Ivan Spasojevic, and Edith B. Gralla. “Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.” Redox Biology 3 (January 1, 2014): 1–6. https://doi.org/10.1016/j.redox.2014.0.003.
       Full Text  Link to Item
    • Batinic-Haberle, I., A. Tovmasyan, and I. Spasojevic. “The complex mechanistic aspects of redox-active compounds, commonly regarded as SOD mimics.” Bioinorganic Reaction Mechanisms 9, no. 1–4 (December 1, 2013): 35–58. https://doi.org/10.1515/irm-2013-0004.
       Full Text
    • Batinic-Haberle, Ines, Artak Tovmasyan, Tin Weitner, Zrinka Rajic, Stephen T. Keir, Ting-Ting Huang, David Leu, et al. “Mechanistic Considerations of the Therapeutic Effects of Mn Porphyrins, Commonly Regarded as SOD Mimics, in Anticancer Therapy: Lessons from Brain and Lymphoma Studies.” Free Radical Biology and Medicine 65 (November 2013): S120–21. https://doi.org/10.1016/j.freeradbiomed.2013.10.691.
       Full Text
    • Spasojevic, Ivan, Tin Weitner, Artak Tovmasyan, Huaxin Sheng, Sumitra Miriyala, David Leu, Zrinka Rajic, et al. “Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” Free Radical Biology and Medicine 65 (November 2013): S132–S132. https://doi.org/10.1016/j.freeradbiomed.2013.10.728.
       Full Text  Open Access Copy
    • Tovmasyan, Artak, Tin Weitner, Huaxin Sheng, MiaoMiao Lu, Zrinka Rajic, David S. Warner, Ivan Spasojevic, Julio S. Reboucas, Ludmil Benov, and Ines Batinic-Haberle. “Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.” Inorg Chem 52, no. 10 (May 20, 2013): 5677–91. https://doi.org/10.1021/ic3012519.
       Full Text  Open Access Copy  Link to Item
    • Weitner, Tin, Ivan Kos, Huaxin Sheng, Artak Tovmasyan, Julio S. Reboucas, Ping Fan, David S. Warner, Zeljko Vujaskovic, Ines Batinic-Haberle, and Ivan Spasojevic. “Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” Free Radic Biol Med 58 (May 2013): 73–80. https://doi.org/10.1016/j.freeradbiomed.2013.01.006.
       Full Text  Open Access Copy  Link to Item
    • Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.
       Full Text  Open Access Copy  Link to Item
    • Tovmasyan, Artak, Huaxin Sheng, Tin Weitner, Amanda Arulpragasam, Miaomiao Lu, David S. Warner, Zeljko Vujaskovic, Ivan Spasojevic, and Ines Batinic-Haberle. “Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.” Med Princ Pract 22, no. 2 (2013): 103–30. https://doi.org/10.1159/000341715.
       Full Text  Open Access Copy  Link to Item
    • Reitman, Zachary J., Bryan D. Choi, Ivan Spasojevic, Darell D. Bigner, John H. Sampson, and Hai Yan. “Enzyme redesign guided by cancer-derived IDH1 mutations.” Nat Chem Biol 8, no. 11 (November 2012): 887–89. https://doi.org/10.1038/nchembio.1065.
       Full Text  Link to Item
    • Spasojevic, Ivan, Ligia R. S. da Costa, Mitchell E. Horwitz, Gwynn D. Long, Keith M. Sullivan, John P. Chute, Cristina Gasparetto, Ashley Morris, Nelson J. Chao, and David A. Rizzieri. “Mini test dose of intravenous busulfan (busulfex(®)) in allogeneic non-myeloablative stem cell transplantation, followed by liquid chromatography tandem-mass spectrometry.” Cancer Invest 30, no. 9 (November 2012): 679–82. https://doi.org/10.3109/07357907.2012.726386.
       Full Text  Link to Item
    • Il’yasova, Dora, Peter Scarbrough, and Ivan Spasojevic. “Urinary biomarkers of oxidative status.” Clin Chim Acta 413, no. 19–20 (October 9, 2012): 1446–53. https://doi.org/10.1016/j.cca.2012.06.012.
       Full Text  Link to Item
    • Wu, Jing, Guorong Li, Coralia Luna, Ivan Spasojevic, David L. Epstein, and Pedro Gonzalez. “Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation.” Invest Ophthalmol Vis Sci 53, no. 11 (October 1, 2012): 7142–48. https://doi.org/10.1167/iovs.12-9968.
       Full Text  Link to Item
    • Il’yasova, Dora, Frances Wang, Ivan Spasojevic, Karel Base, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI.” Obesity (Silver Spring) 20, no. 10 (October 2012): 2147–50. https://doi.org/10.1038/oby.2012.170.
       Full Text  Link to Item
    • Il’yasova, Dora, Frances Wang, Ivan Spasojevic, Karel Base, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort.” Obesity (Silver Spring) 20, no. 9 (September 2012): 1915–21. https://doi.org/10.1038/oby.2011.292.
       Full Text  Link to Item
    • Jin, Genglin, Christopher J. Pirozzi, Lee H. Chen, Giselle Y. Lopez, Christopher G. Duncan, Jie Feng, Ivan Spasojevic, Darell D. Bigner, Yiping He, and Hai Yan. “Mutant IDH1 is required for IDH1 mutated tumor cell growth.” Oncotarget 3, no. 8 (August 2012): 774–82. https://doi.org/10.18632/oncotarget.577.
       Full Text  Open Access Copy  Link to Item
    • Siamakpour-Reihani, Sharareh, Peter M. Scarbrough, Frances Wang, Ivan Spasojevic, Karel Base, Rebecca Sedjo, Ralph B. D’Agostino, and Dora Il’yasova. “Systemic markers of oxidative status and colorectal adenomatous polyps.” Ann Epidemiol 22, no. 8 (August 2012): 587–91. https://doi.org/10.1016/j.annepidem.2012.05.001.
       Full Text  Link to Item
    • Miriyala, Sumitra, Ivan Spasojevic, Artak Tovmasyan, Daniela Salvemini, Zeljko Vujaskovic, Daret St Clair, and Ines Batinic-Haberle. “Manganese superoxide dismutase, MnSOD and its mimics.” Biochim Biophys Acta 1822, no. 5 (May 2012): 794–814. https://doi.org/10.1016/j.bbadis.2011.12.002.
       Full Text  Link to Item
    • Rajic, Zrinka, Artak Tovmasyan, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu, Alice M. Li, Edith B. Gralla, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.” Free Radic Biol Med 52, no. 9 (May 1, 2012): 1828–34. https://doi.org/10.1016/j.freeradbiomed.2012.02.006.
       Full Text  Open Access Copy  Link to Item
    • Walko, Christine M., Austin J. Combest, Ivan Spasojevic, Angela Y. C. Yu, Shriya Bhushan, J Heyward Hull, Janelle Hoskins, et al. “The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients.” Cancer Chemother Pharmacol 69, no. 5 (May 2012): 1189–96. https://doi.org/10.1007/s00280-011-1815-5.
       Full Text  Link to Item
    • Pretty, Jack R., Thomas H. Connor, Ivan Spasojevic, Kristine S. Kurtz, Jeffrey L. McLaurin, Clayton B’Hymer, and D Gayle Debord. “Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment.” J Oncol Pharm Pract 18, no. 1 (March 2012): 23–36. https://doi.org/10.1177/1078155210389215.
       Full Text  Link to Item
    • Batinic-Haberle, I., I. Spasojevic, H. M. Tse, A. Tovmasyan, Z. Rajic, D. K. S. Clair, Z. Vujaskovic, M. W. Dewhirst, and J. D. Piganelli. “Erratum: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (Amino Acids DOI: 10.1007/s00726-010-0603-6).” Amino Acids 42, no. 1 (January 1, 2012): 115–16. https://doi.org/10.1007/s00726-010-0821-y.
       Full Text
    • Oberley-Deegan, Rebecca E., Joshua J. Steffan, Kyle O. Rove, Kathryn M. Pate, Michael W. Weaver, Ivan Spasojevic, Barbara Frederick, et al. “The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation.” Plos One 7, no. 9 (2012): e44178. https://doi.org/10.1371/journal.pone.0044178.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Ivan Spasojevic, Hubert M. Tse, Artak Tovmasyan, Zrinka Rajic, Daret K. St Clair, Zeljko Vujaskovic, Mark W. Dewhirst, and Jon D. Piganelli. “Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.” Amino Acids 42, no. 1 (January 2012): 95–113. https://doi.org/10.1007/s00726-010-0603-6.
       Full Text  Link to Item
    • Il’yasova, Dora, Ivan Spasojevic, Karel Base, Haoyue Zhang, Frances Wang, Sarah P. Young, David S. Millington, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes.” Diabetes Care 35, no. 1 (January 2012): 173–74. https://doi.org/10.2337/dc11-1502.
       Full Text  Link to Item
    • Ye, Xiaodong, Diane Fels, Artak Tovmasyan, Katherine M. Aird, Casey Dedeugd, Jennifer L. Allensworth, Ivan Kos, et al. “Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.” Free Radic Res 45, no. 11–12 (November 2011): 1289–1306. https://doi.org/10.3109/10715762.2011.616199.
       Full Text  Link to Item
    • Dogan, Serdar, Mustafa Unal, Nihal Ozturk, Piraye Yargicoglu, Aysegul Cort, Ivan Spasojevic, Ines Batinic-Haberle, and Mutay Aslan. “Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats.” Exp Eye Res 93, no. 4 (October 2011): 387–96. https://doi.org/10.1016/j.exer.2011.05.008.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Zrinka Rajic, Artak Tovmasyan, Julio S. Reboucas, Xiaodong Ye, Kam W. Leong, Mark W. Dewhirst, Zeljko Vujaskovic, Ludmil Benov, and Ivan Spasojevic. “Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.” Free Radic Biol Med 51, no. 5 (September 1, 2011): 1035–53. https://doi.org/10.1016/j.freeradbiomed.2011.04.046.
       Full Text  Link to Item
    • Sheng, Huaxin, Ivan Spasojevic, Hubert M. Tse, Jin Yong Jung, Jun Hong, Zhiquan Zhang, Jon D. Piganelli, Ines Batinic-Haberle, and David S. Warner. “Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.” J Pharmacol Exp Ther 338, no. 3 (September 2011): 906–16. https://doi.org/10.1124/jpet.110.176701.
       Full Text  Open Access Copy  Link to Item
    • Osada, Takuya, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B. Vandeusen, David Hsu, Bryan M. Clary, et al. “Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.” Cancer Res 71, no. 12 (June 15, 2011): 4172–82. https://doi.org/10.1158/0008-5472.CAN-10-3978.
       Full Text  Link to Item
    • Tovmasyan, Artak G., Zrinka Rajic, Ivan Spasojevic, Julio S. Reboucas, Xin Chen, Daniela Salvemini, Huaxin Sheng, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.” Dalton Trans 40, no. 16 (April 28, 2011): 4111–21. https://doi.org/10.1039/c0dt01321h.
       Full Text  Open Access Copy  Link to Item
    • Jones, Lee W., Neil D. Eves, Ivan Spasojevic, Frances Wang, and Dora Il’yasova. “Effects of aerobic training on oxidative status in postsurgical non-small cell lung cancer patients: a pilot study.” Lung Cancer 72, no. 1 (April 2011): 45–51. https://doi.org/10.1016/j.lungcan.2010.08.002.
       Full Text  Link to Item
    • Batinic-Haberle, I., J. S. Reboucas, and I. Spasojevic. “Response to Rosenthal et al.” Antioxidants and Redox Signaling 14, no. 6 (March 15, 2011): 1174–76. https://doi.org/10.1089/ars.2010.3758.rs.
       Full Text
    • Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270–75. https://doi.org/10.1073/pnas.1019393108.
       Full Text  Link to Item
    • Jin, Genglin, Zachary J. Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D. Bigner, and Hai Yan. “2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.” Plos One 6, no. 2 (February 4, 2011): e16812. https://doi.org/10.1371/journal.pone.0016812.
       Full Text  Link to Item
    • Spasojevic, Ivan, Ivan Kos, Ludmil T. Benov, Zrinka Rajic, Diane Fels, Casey Dedeugd, Xiaodong Ye, et al. “Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.” Free Radic Res 45, no. 2 (February 2011): 188–200. https://doi.org/10.3109/10715762.2010.522575.
       Full Text  Link to Item
    • Il’yasova, Dora, Kelly Kennedy, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, et al. “Individual responses to chemotherapy-induced oxidative stress.” Breast Cancer Res Treat 125, no. 2 (January 2011): 583–89. https://doi.org/10.1007/s10549-010-1158-7.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Júlio S. Rebouças, and Ivan Spasojević. “Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.” Antioxid Redox Signal 13, no. 6 (September 15, 2010): 877–918. https://doi.org/10.1089/ars.2009.2876.
       Full Text  Open Access Copy  Link to Item
    • Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.” Plos One 5, no. 6 (June 16, 2010): e11056. https://doi.org/10.1371/journal.pone.0011056.
       Full Text  Open Access Copy  Link to Item
    • Il’yasova, Dora, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, P Kelly Marcom, et al. “Urinary biomarkers of oxidative status in a clinical model of oxidative assault.” Cancer Epidemiol Biomarkers Prev 19, no. 6 (June 2010): 1506–10. https://doi.org/10.1158/1055-9965.EPI-10-0211.
       Full Text  Link to Item
    • Tailor, Tina D., Gabi Hanna, Pavel S. Yarmolenko, Matthew R. Dreher, Allison S. Betof, Andrew B. Nixon, Ivan Spasojevic, and Mark W. Dewhirst. “Effect of pazopanib on tumor microenvironment and liposome delivery.” Mol Cancer Ther 9, no. 6 (June 2010): 1798–1808. https://doi.org/10.1158/1535-7163.MCT-09-0856.
       Full Text  Link to Item
    • Palmer, Gregory M., Richard J. Boruta, Benjamin L. Viglianti, Lan Lan, Ivan Spasojevic, and Mark W. Dewhirst. “Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy.” J Control Release 142, no. 3 (March 19, 2010): 457–64. https://doi.org/10.1016/j.jconrel.2009.10.034.
       Full Text  Link to Item
    • Yarmolenko, Pavel S., Yulin Zhao, Chelsea Landon, Ivan Spasojevic, Fan Yuan, David Needham, Benjamin L. Viglianti, and Mark W. Dewhirst. “Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.” Int J Hyperthermia 26, no. 5 (2010): 485–98. https://doi.org/10.3109/02656731003789284.
       Full Text  Link to Item
    • Kos, Ivan, Ludmil Benov, Ivan Spasojević, Júlio S. Rebouças, and Ines Batinić-Haberle. “High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.” J Med Chem 52, no. 23 (December 10, 2009): 7868–72. https://doi.org/10.1021/jm900576g.
       Full Text  Link to Item
    • Doyle, T., L. Bryant, I. Batinic-Haberle, J. Little, S. Cuzzocrea, E. Masini, I. Spasojevic, and D. Salvemini. “Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.” Neuroscience 164, no. 2 (December 1, 2009): 702–10. https://doi.org/10.1016/j.neuroscience.2009.07.019.
       Full Text  Link to Item
    • Voora, Deepak, Svati H. Shah, Ivan Spasojevic, Shazia Ali, Carol R. Reed, Benjamin A. Salisbury, and Geoffrey S. Ginsburg. “The SLCO1B1*5 genetic variant is associated with statin-induced side effects.” J Am Coll Cardiol 54, no. 17 (October 20, 2009): 1609–16. https://doi.org/10.1016/j.jacc.2009.04.053.
       Full Text  Link to Item
    • Rabbani, Zahid N., Ivan Spasojevic, Xiuwu Zhang, Benjamin J. Moeller, Sinisa Haberle, Jeannette Vasquez-Vivar, Mark W. Dewhirst, Zeljko Vujaskovic, and Ines Batinic-Haberle. “Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.” Free Radic Biol Med 47, no. 7 (October 1, 2009): 992–1004. https://doi.org/10.1016/j.freeradbiomed.2009.07.001.
       Full Text  Link to Item
    • Kos, Ivan, Júlio S. Rebouças, Gilson DeFreitas-Silva, Daniela Salvemini, Zeljko Vujaskovic, Mark W. Dewhirst, Ivan Spasojević, and Ines Batinić-Haberle. “Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.” Free Radic Biol Med 47, no. 1 (July 1, 2009): 72–78. https://doi.org/10.1016/j.freeradbiomed.2009.04.002.
       Full Text  Link to Item
    • McMahon, N., T. Y. Cheng, G. M. Beasley, I. Spasojevic, W. Petros, C. K. Augustine, P. Zipfel, J. C. Padussis, G. Sanders, and Douglas S. Tyler. “Optimizing melphalan pharmacokinetics in regional melanoma therapy: does correcting for ideal body weight alter regional response or toxicity?” Ann Surg Oncol 16, no. 4 (April 2009): 953–61. https://doi.org/10.1245/s10434-008-0288-1.
       Full Text  Link to Item
    • Wise-Faberowski, Lisa, David S. Warner, Ivan Spasojevic, and Ines Batinic-Haberle. “Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.” Free Radic Res 43, no. 4 (April 2009): 329–39. https://doi.org/10.1080/10715760902736283.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Michael M. Ndengele, Salvatore Cuzzocrea, Júlio S. Rebouças, Ivan Spasojević, and Daniela Salvemini. “Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.” Free Radic Biol Med 46, no. 2 (January 15, 2009): 212–19. https://doi.org/10.1016/j.freeradbiomed.2008.09.037.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Salvatore Cuzzocrea, Júlio S. Rebouças, Gerardo Ferrer-Sueta, Emanuela Mazzon, Rosanna Di Paola, Rafael Radi, Ivan Spasojević, Ludmil Benov, and Daniela Salvemini. “Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.” Free Radic Biol Med 46, no. 2 (January 15, 2009): 192–201. https://doi.org/10.1016/j.freeradbiomed.2008.09.042.
       Full Text  Link to Item
    • Rebouças, Júlio S., Ivan Spasojević, and Ines Batinić-Haberle. “Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.” J Pharm Biomed Anal 48, no. 3 (November 4, 2008): 1046–49. https://doi.org/10.1016/j.jpba.2008.08.005.
       Full Text  Link to Item
    • Spasojević, Ivan, Yumin Chen, Teresa J. Noel, Ping Fan, Lichun Zhang, Julio S. Rebouças, Daret K. St Clair, and Ines Batinić-Haberle. “Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice.” Free Radic Biol Med 45, no. 7 (October 1, 2008): 943–49. https://doi.org/10.1016/j.freeradbiomed.2008.05.015.
       Full Text  Link to Item
    • DeFreitas-Silva, Gilson, Júlio S. Rebouças, Ivan Spasojević, Ludmil Benov, Ynara M. Idemori, and Ines Batinić-Haberle. “SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself.” Arch Biochem Biophys 477, no. 1 (September 1, 2008): 105–12. https://doi.org/10.1016/j.abb.2008.04.032.
       Full Text  Link to Item
    • Rao, Arati V., Islam R. Younis, Gregory J. Sand, Ivan Spasojevic, David J. Adams, Carlos M. Decastro, John P. Gockerman, et al. “Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia.” Leuk Lymphoma 49, no. 8 (August 2008): 1523–29. https://doi.org/10.1080/10428190802210700.
       Full Text  Link to Item
    • Rebouças, Júlio S., Gilson DeFreitas-Silva, Ivan Spasojević, Ynara M. Idemori, Ludmil Benov, and Ines Batinić-Haberle. “Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.” Free Radic Biol Med 45, no. 2 (July 15, 2008): 201–10. https://doi.org/10.1016/j.freeradbiomed.2008.04.009.
       Full Text  Link to Item
    • Rebouças, Júlio S., Ivan Spasojević, Daryono H. Tjahjono, Arlette Richaud, Francisco Méndez, Ludmil Benov, and Ines Batinić-Haberle. “Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.” Dalton Trans, no. 9 (March 7, 2008): 1233–42. https://doi.org/10.1039/b716517j.
       Full Text  Link to Item
    • Rebouças, Júlio S., Ivan Spasojević, and Ines Batinić-Haberle. “Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology.” J Biol Inorg Chem 13, no. 2 (February 2008): 289–302. https://doi.org/10.1007/s00775-007-0324-9.
       Full Text  Link to Item
    • Horwitz, Mitchell E., Ivan Spasojevic, Ashley Morris, Marilyn Telen, James Essell, Cristina Gasparetto, Keith Sullivan, et al. “Fludarabine-based nonmyeloablative stem cell transplantation for sickle cell disease with and without renal failure: clinical outcome and pharmacokinetics.” Biol Blood Marrow Transplant 13, no. 12 (December 2007): 1422–26. https://doi.org/10.1016/j.bbmt.2007.08.050.
       Full Text  Link to Item
    • Lahaye, Dorothée, Kannan Muthukumaran, Chen-Hsiung Hung, Dorota Gryko, Júlio S. Rebouças, Ivan Spasojević, Ines Batinić-Haberle, and Jonathan S. Lindsey. “Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity.” Bioorg Med Chem 15, no. 22 (November 15, 2007): 7066–86. https://doi.org/10.1016/j.bmc.2007.07.015.
       Full Text  Link to Item
    • Vlahovic, G., A. M. Ponce, Z. Rabbani, F. K. Salahuddin, L. Zgonjanin, I. Spasojevic, Z. Vujaskovic, and M. W. Dewhirst. “Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts.” Br J Cancer 97, no. 6 (September 17, 2007): 735–40. https://doi.org/10.1038/sj.bjc.6603941.
       Full Text  Link to Item
    • Emmenegger, Urban, Yuval Shaked, Shan Man, Guido Bocci, Ivan Spasojevic, Giulio Francia, Andrew Kouri, et al. “Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice.” Mol Cancer Ther 6, no. 8 (August 2007): 2280–89. https://doi.org/10.1158/1535-7163.MCT-07-0181.
       Full Text  Link to Item
    • Xu, Yong, Fang Fang, Daret K. St Clair, Sajni Josson, Pradoldej Sompol, Ivan Spasojevic, and William H. St Clair. “Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cells.” Mol Cancer Ther 6, no. 7 (July 2007): 2048–56. https://doi.org/10.1158/1535-7163.MCT-06-0700.
       Full Text  Link to Item
    • Spasojević, Ivan, Yumin Chen, Teresa J. Noel, Yiqun Yu, Marsha P. Cole, Lichun Zhang, Yunfeng Zhao, Daret K. St Clair, and Ines Batinić-Haberle. “Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria.” Free Radic Biol Med 42, no. 8 (April 15, 2007): 1193–1200. https://doi.org/10.1016/j.freeradbiomed.2007.01.019.
       Full Text  Link to Item
    • Kleiter, Miriam M., Daohai Yu, Lenore A. Mohammadian, Nelsen Niehaus, Ivan Spasojevic, Linda Sanders, Benjamin L. Viglianti, et al. “A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.” Clin Cancer Res 12, no. 22 (November 15, 2006): 6800–6807. https://doi.org/10.1158/1078-0432.CCR-06-0839.
       Full Text  Link to Item
    • Spasojević, Ivan, O Michael Colvin, Keith R. Warshany, and Ines Batinić-Haberle. “New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.” J Inorg Biochem 100, no. 11 (November 2006): 1897–1902. https://doi.org/10.1016/j.jinorgbio.2006.07.013.
       Full Text  Link to Item
    • Hauck, Marlene L., Susan M. LaRue, William P. Petros, Jean M. Poulson, Daohai Yu, Ivan Spasojevic, Amy F. Pruitt, et al. “Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors.” Clin Cancer Res 12, no. 13 (July 1, 2006): 4004–10. https://doi.org/10.1158/1078-0432.CCR-06-0226.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Ivan Spasojević, Robert D. Stevens, Bruce Bondurant, Ayako Okado-Matsumoto, Irwin Fridovich, Zeljko Vujasković, and Mark W. Dewhirst. “New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.” Dalton Trans, no. 4 (January 28, 2006): 617–24. https://doi.org/10.1039/b513761f.
       Full Text  Link to Item
    • Moeller, Benjamin J., Ines Batinic-Haberle, Ivan Spasojevic, Zahid N. Rabbani, Mitchell S. Anscher, Zeljko Vujaskovic, and Mark W. Dewhirst. “A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.” Int J Radiat Oncol Biol Phys 63, no. 2 (October 1, 2005): 545–52. https://doi.org/10.1016/j.ijrobp.2005.05.026.
       Full Text  Link to Item
    • Alvarez Secord, A., E. L. Jones, C. A. Hahn, W. P. Petros, D. Yu, L. J. Havrilesky, J. T. Soper, et al. “Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.” Int J Hyperthermia 21, no. 4 (June 2005): 333–47. https://doi.org/10.1080/02656730500110155.
       Full Text  Link to Item
    • Sheng, Huaxin, Ivan Spasojevic, David S. Warner, and Ines Batinic-Haberle. “Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy.” Neurosci Lett 366, no. 2 (August 12, 2004): 220–25. https://doi.org/10.1016/j.neulet.2004.05.050.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Ivan Spasojević, and Irwin Fridovich. “Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin.” Free Radic Biol Med 37, no. 3 (August 1, 2004): 367–74. https://doi.org/10.1016/j.freeradbiomed.2004.04.041.
       Full Text  Link to Item
    • Batinić-Haberle, Ines, Ivan Spasojević, Robert D. Stevens, Peter Hambright, Pedatsur Neta, Ayako Okado-Matsumoto, and Irwin Fridovich. “New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.” Dalton Trans, no. 11 (June 7, 2004): 1696–1702. https://doi.org/10.1039/b400818a.
       Full Text  Link to Item
    • Sheng, Huaxin, Haichen Wang, Hercilia M. Homi, Ivan Spasojevic, Ines Batinic-Haberle, Robert D. Pearlstein, and David S. Warner. “A no-laminectomy spinal cord compression injury model in mice.” J Neurotrauma 21, no. 5 (May 2004): 595–603. https://doi.org/10.1089/089771504774129928.
       Full Text  Link to Item
    • Kachadourian, Remy, Chris A. Johnson, Elysia Min, Ivan Spasojevic, and Brian J. Day. “Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins.” Biochem Pharmacol 67, no. 1 (January 1, 2004): 77–85. https://doi.org/10.1016/j.bcp.2003.08.036.
       Full Text  Link to Item
    • Spasojevic, Ivan, Ines Batinic-Haberle, Julio S. Reboucas, Ynara Marina Idemori, and Irwin Fridovich. “Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.” J Biol Chem 278, no. 9 (February 28, 2003): 6831–37. https://doi.org/10.1074/jbc.M211346200.
       Full Text  Link to Item
    • Hambright, P., I. Batinić-Haberle, and I. Spasojević. “Meso tetrakis ortho-, meta-, and para-n-alkylpyridinioporphyrins: Kinetics of copper(II) and zinc(II) incorporation and zinc porphyrin demetalation.” Journal of Porphyrins and Phthalocyanines 7, no. 3 (January 1, 2003): 139–46. https://doi.org/10.1142/S1088424603000197.
       Full Text
    • Spasojević, Ivan, Ramil Menzeleev, Peter S. White, and Irwin Fridovich. “Rotational isomers of N-alkylpyridylporphyrins and their metal complexes. HPLC separation, (1)H NMR and X-ray structural characterization, electrochemistry, and catalysis of O(2)(.-) disproportionation.” Inorg Chem 41, no. 22 (November 4, 2002): 5874–81. https://doi.org/10.1021/ic025556x.
       Full Text  Link to Item
    • Vujaskovic, Zeljko, Ines Batinic-Haberle, Zahid N. Rabbani, Qin-fu Feng, Song K. Kang, Ivan Spasojevic, Thaddeus V. Samulski, Irwin Fridovich, Mark W. Dewhirst, and Mitchell S. Anscher. “A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.” Free Radic Biol Med 33, no. 6 (September 15, 2002): 857–63. https://doi.org/10.1016/s0891-5849(02)00980-2.
       Full Text  Link to Item
    • Benov, Ludmil, Ines Batinić-Haberle, Ivan Spasojević, and Irwin Fridovich. “Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers.” Arch Biochem Biophys 402, no. 2 (June 15, 2002): 159–65. https://doi.org/10.1016/S0003-9861(02)00062-0.
       Full Text  Link to Item
    • Wirgau, Joseph I., Ivan Spasojević, Hakim Boukhalfa, Ines Batinić-Haberle, and Alvin L. Crumbliss. “Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid.” Inorg Chem 41, no. 6 (March 25, 2002): 1464–73. https://doi.org/10.1021/ic0109795.
       Full Text  Link to Item
    • Batinić-Haberle, I., I. Spasojević, R. D. Stevens, P. Hambright, and I. Fridovich. “Manganese(III) meso-tetrakis(ortho-N-alkylpyridyl)porphyrins. Synthesis, characterization, and catalysis of O2/^·- dismutation.” Journal of the Chemical Society, Dalton Transactions, no. 13 (January 1, 2002): 2689–96. https://doi.org/10.1039/b201057g.
       Full Text
    • Nguyen-Van-Duong, M. K., V. Guillot, L. Nicolas, A. Gaudemer, L. Lowry, I. Spasojević, and A. L. Crumbliss. “Synthesis, ligand pK(a), and Fe(III) complexation constants for a series of bipodal dihydroxamic acids.” Inorg Chem 40, no. 23 (November 5, 2001): 5948–53. https://doi.org/10.1021/ic0103143.
       Full Text  Link to Item
    • Spasojević, I., I. Batinić-Haberle, R. D. Stevens, P. Hambright, A. N. Thorpe, J. Grodkowski, P. Neta, and I. Fridovich. “Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple.” Inorg Chem 40, no. 4 (February 12, 2001): 726–39. https://doi.org/10.1021/ic0004986.
       Full Text  Link to Item
    • Spasojević, I., H. Boukhalfa, R. D. Stevens, and A. L. Crumbliss. “Aqueous solution speciation of Fe(III) complexes with dihydroxamate siderophores alcaligin and rhodotorulic acid and synthetic analogues using electrospray ionization mass spectrometry.” Inorg Chem 40, no. 1 (January 1, 2001): 49–58. https://doi.org/10.1021/ic991390x.
       Full Text  Link to Item
    • Spasojevic, I., I. Batinic-Haberle, and I. Fridovich. “Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide.” Nitric Oxide 4, no. 5 (October 2000): 526–33. https://doi.org/10.1006/niox.2000.0303.
       Full Text  Link to Item
    • Spasojevic, I., S. I. Liochev, and I. Fridovich. “Lucigenin: redox potential in aqueous media and redox cycling with O-(2) production.” Arch Biochem Biophys 373, no. 2 (January 15, 2000): 447–50. https://doi.org/10.1006/abbi.1999.1579.
       Full Text  Link to Item
    • Ferrer-Sueta, G., I. Batinić-Haberle, I. Spasojević, I. Fridovich, and R. Radi. “Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.” Chem Res Toxicol 12, no. 5 (May 1999): 442–49. https://doi.org/10.1021/tx980245d.
       Full Text  Link to Item
    • Spasojevic, Ivan, Sandra K. Armstrong, Timothy J. Brickman, and Alvin L. Crumbliss. “Electrochemical Behavior of the Fe(III) Complexes of the Cyclic Hydroxamate Siderophores Alcaligin and Desferrioxamine E.” Inorg Chem 38, no. 3 (February 8, 1999): 449–54. https://doi.org/10.1021/ic980635n.
       Full Text  Link to Item
    • Batinić-Haberle, I., I. Spasojević, P. Hambright, L. Benov, A. L. Cmmbliss, and I. Fridovich. “Relationship among redox potentials, proton dissociation constants of pyrrolic nitrogens, and in vivo and in vitro superoxide dismutating activities of manganese(III) and iron(III) water-soluble porphyrins.” Inorganic Chemistry 38, no. 18 (January 1, 1999): 4011–22. https://doi.org/10.1021/ic990118k.
       Full Text
    • Spasojević, I., and A. L. Crumbliss. “PH induced active ("Uphill") liquid membrane transport of ferrioxamine B by the ionizable ionophore lasalocid.” Inorganic Chemistry 38, no. 13 (January 1, 1999): 3248–50. https://doi.org/10.1021/ic9813664.
       Full Text
    • Spasojević, I., and A. L. Crumbliss. “Bulk liquid membrane transport of ferrioxamine B by neutral and ionizable carriers.” Journal of the Chemical Society  Dalton Transactions, no. 23 (December 7, 1998): 4021–27. https://doi.org/10.1039/a804391d.
       Full Text
    • Batinić-Haberle, I., L. Benov, I. Spasojević, and I. Fridovich. “The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.” J Biol Chem 273, no. 38 (September 18, 1998): 24521–28. https://doi.org/10.1074/jbc.273.38.24521.
       Full Text  Link to Item
    • Batinić-Haberle, I., I. Spasojević, Y. Jang, R. A. Bartsch, and A. L. Crumbliss. “Lariat Ether Carboxylic Acids as Ionizable Hosts in the Second Coordination Sphere of the Siderophore Ferrioxamine B in Chloroform.” Inorganic Chemistry 37, no. 7 (January 1, 1998): 1438–45. https://doi.org/10.1021/ic970925o.
       Full Text
    • Batinić-Haberle, I., I. Spasojević, and A. L. Crumbliss. “Solvent effect on second-sphere coordination of ferrioxamine B with substituted 18-crown-6 and 30-crown-10 crown ethers in dichloromethane as compared to chloroform.” Inorganica Chimica Acta 260, no. 1 (July 15, 1997): 35–41. https://doi.org/10.1016/S0020-1693(96)05528-4.
       Full Text
    • Batinić-Haberle, I., S. I. Liochev, I. Spasojević, and I. Fridovich. “A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin.” Arch Biochem Biophys 343, no. 2 (July 15, 1997): 225–33. https://doi.org/10.1006/abbi.1997.0157.
       Full Text  Link to Item
    • Crumbliss, A. L., I. Batinić-Haberle, and I. Spasojević. “Molecular recognition of stable metal complexes through second-sphere coordination by macrocycles.” Pure and Applied Chemistry 68, no. 6 (January 1, 1996): 1225–30. https://doi.org/10.1351/pac199668061225.
       Full Text
    • Batinić-Haberle, I., I. Spasojević, R. A. Bartsch, and A. L. Crumbliss. “Stereochemical factors affecting second-sphere co-ordination of ferrioxamine B with cis-syn-cis and cis-anti-cis isomers of dicyclohexano-18-crown-6 in chloroform and a comparison with alkali-metal and ammonium cations.” Journal of the Chemical Society, Dalton Transactions, no. 15 (December 1, 1995): 2503–8. https://doi.org/10.1039/DT9950002503.
       Full Text
    • Batinić-Haberle, I., I. Spasojević, and A. L. Crumbliss. “Hydrolysis of Ferrioxamine B in Aqueous Micellar Solution.” Inorganic Chemistry 33, no. 14 (July 1, 1994): 3151–58. https://doi.org/10.1021/ic00092a022.
       Full Text
    • Spasojević, I., I. Batinfć-Haberle, P. L. Choo, and A. L. Crumbliss. “Supramolecular Assembly Formation of Ferrioxamine B and Its Al(III), Ga(III), and In(III) Analogues with Dicyclohexano-18-Crown-6 in Chloroform.” Journal of the American Chemical Society 116, no. 13 (June 1, 1994): 5714–21. https://doi.org/10.1021/ja00092a023.
       Full Text
    • Spasojevic̈, I., I. Batinic̈‐Haberle, and D. Baris̈in. “Functional and chemical characterization of the aging process of an igniter.” Propellants, Explosives, Pyrotechnics 18, no. 2 (January 1, 1993): 89–92. https://doi.org/10.1002/prep.19930180208.
       Full Text
    • Batinic‐Haberle, I., D. Barisin, I. Spasojevic, and Z. Vranic. “The stability characterization of the pyrotechnic system. The degradation of the nitrate oxidant in the presence of the magnesium under the accelerated aging conditions.” Propellants, Explosives, Pyrotechnics 17, no. 1 (January 1, 1992): 10–13. https://doi.org/10.1002/prep.19920170104.
       Full Text

  • Book Sections

    • Batinic-Haberle, I., and I. Spasojevic. “25 years of development of Mn porphyrins - from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA.” In Porphyrin Science By Women (In 3 Volumes), 197–206, 2020. https://doi.org/10.1142/S1088424619300283.
       Full Text
    • Batinic-Haberle, Ines, Julio S. Reboucas, and Ivan Spasojevic. “Redox-Active Therapeutics Preface.” In REDOX-ACTIVE THERAPEUTICS, IX–XIV, 2016.
       Link to Item
    • Batinić-Haberle, Ines, Artak Tovmasyan, and Ivan Spasojević. “Mn Porphyrin-Based Redox-Active Therapeutics.” In Oxidative Stress in Applied Basic Research and Clinical Practice, 165–212. Springer International Publishing, 2016. https://doi.org/10.1007/978-3-319-30705-3_8.
       Full Text
    • Pinto, Victor Hugo A., Nathália K. S. M. Falcão, Jacqueline C. Bueno-Janice, Ivan Spasojević, Ines Batinić-Haberle, and Júlio S. Rebouças. “Cytochrome P450-Like Biomimetic Oxidation Catalysts Based on Mn Porphyrins as Redox Modulators.” In Oxidative Stress in Applied Basic Research and Clinical Practice, 213–43. Springer International Publishing, 2016. https://doi.org/10.1007/978-3-319-30705-3_9.
       Full Text
    • Batinic-Haberle, Ines, Julio S. Reboucas, Ludmil Benov, and Ivan Spasojevic. “Chemistry, Biology and Medical Effects of Water-Soluble Metalloporphyrins.” In HANDBOOK OF PORPHYRIN SCIENCE WITH APPLICATIONS TO CHEMISTRY, PHYSICS, MATERIALS SCIENCE, ENGINEERING, BIOLOGY AND MEDICINE, VOL 11, 11:291–393, 2011.
       Link to Item

  • Conference Papers

    • Grimberg, Dominic C., Scott P. Campbell, Wiguins Etienne, Ping Fan, Paolo F. Maccarini, Ivan Spasojevic, Rohith Arcot, Ankeet Shah, and Brant Allen Inman. “Hyperthermia, bladder pressure, and intravesical drug delivery.” In Journal of Clinical Oncology, 39:469–469. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.6_suppl.469.
       Full Text
    • Batinic-Haberle, Ines, Weina Duan, Li Du, Zhiqing Huang, Artak Tovmasyan, Zhipeng Cao, Shara Reihani, Ivan Spasojevic, Huaxin Sheng, and Angeles Alvarez Secord. “MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer.” In Free Radical Biology and Medicine, 159:S51–S51. Elsevier BV, 2020. https://doi.org/10.1016/j.freeradbiomed.2020.10.138.
       Full Text
    • Zhang, Tian, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Hannah Berg, et al. “Disulfiram (DSF) pharmacokinetics (PK) and copper PET imaging in a phase Ib study of intravenous (IV) copper loading with oral DSF for patients with metastatic castration-resistant prostate cancer (mCRPC).” In Journal of Clinical Oncology, Vol. 38. AMER SOC CLINICAL ONCOLOGY, 2020.
       Link to Item
    • Abaffy, Tatjana, James Bain, Michael Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara O’Neal, So Young Kim, and Hiroaki Matsunami. “Discovery of endogenous ligands and the function of OR51E2 in prostate cancer.” In Chemical Senses, 45:130–130, 2020.
       Link to Item
    • Peters, Katherine B., Adam Louis Cohen, Nicholas A. Butowski, John L. Villano, Pierre Giglio, Tresa McGranahan, Chi Zhang, et al. “BMX-HGG: Phase II trial of newly diagnosed high-grade glioma treated with concurrent radiation therapy, temozolomide, and BMX-001.” In Journal of Clinical Oncology, Vol. 38, 2020.
       Link to Item
    • Peters, Katherine B., John Kirkpatrick, I. Batinic-Haberle, Mary L. Affronti, Sarah Woodring, Deborah Iden, Eric S. Lipp, et al. “Cognitive Outcomes of Phase I Trial of Novel Metalloporphyrin Radioprotectant and Radiosensitizer in Newly Diagnosed High Grade Glioma Patients.” In Supportive Care in Cancer. Springer (part of Springer Nature), 2020.
    • Schaller, Teilo, Matthew Foster, Ivan Spasojevic, Patrick Gedeon, Luis Sanchez-Perez, and John Sampson. “FIRST-IN-HUMAN DOSING CONSIDERATIONS OF A BISPECIFIC ANTIBODY FOR TREATING GLIOBLASTOMA.” In Neuro Oncology, 21:84–84. OXFORD UNIV PRESS INC, 2019.
       Link to Item
    • Peters, Katherine, John Kirkpatrick, Ines Batinic-Haberle, Mary Affronti, Sarah Woodring, Deborah Iden, Sujata Panta, et al. “PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS.” In Neuro Oncology, 20:1vi7-vi17. OXFORD UNIV PRESS INC, 2018. https://doi.org/10.1093/neuonc/noy148.061.
       Full Text  Link to Item
    • Peters, Katherine, John Kirkpatrick, Ines Batinic-Haberle, Mary Affronti, Sarah Woodring, Deborah Iden, Sujata Panta, et al. “ACTR-28. PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS.” In Neuro Oncology, 20:vi17–vi17. Oxford University Press (OUP), 2018. https://doi.org/10.1093/neuonc/noy148.061.
       Full Text  Link to Item
    • Batinic-Haberle, Ines, Artak Tovmasyan, Ashley Veade, Ivan Spasojevic, Shara Reihani, and Angeles Secord. “Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy.” In Free Radical Biology and Medicine, 128:S74–75. Elsevier BV, 2018. https://doi.org/10.1016/j.freeradbiomed.2018.10.162.
       Full Text
    • Adams, David, Keith Sullivan, Ivan Spasojevic, Ping Fan, Mario Sampson, Michael Cohen-Wolkowiez, L William St Clair, et al. “Pharmacokinetics of Cyclophosphamide in Scleroderma Treated By Cyclophosphamide Versus Transplantation.” In Arthritis & Rheumatology, Vol. 70. WILEY, 2018.
       Link to Item
    • Yao, ZhongKe, Suzanne Wardell, Ivan Spasojevic, John Norris, John Katzenellenbogen, Donald McDonnell, and Jatinder S. Josan. “Abstract 1805: Development of a selective androgen receptor degrader (SARD) for treatment of castration-resistant prostate cancer.” In Cancer Research, 78:1805–1805. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-1805.
       Full Text
    • Chaiswing, Luksana, Chontida Yarana, Dustin Carroll, Michael Alstott, Allan Butterfield, Subbarao Bondada, Ines Batinic-Haber, Ivan Spasojevic, and Daret St Clair. “Redox State Determines the Differential Effects of Redox-Cycle Compounds in Chemoresistant Ovarian Cancer Cells.” In Free Radical Biology and Medicine, 112:86–86. Elsevier BV, 2017. https://doi.org/10.1016/j.freeradbiomed.2017.10.124.
       Full Text
    • Huang, Ting-Ting, Phillip Yang, David Leu, Artak Tovmasyan, Ivan Spasojevic, and Ines Batinic-Haberle. “Protection Of Neurocognitive Function During Cranial Irradiation Of Brain Tumors.” In Free Radical Biology and Medicine, 112:13–13. Elsevier BV, 2017. https://doi.org/10.1016/j.freeradbiomed.2017.10.366.
       Full Text
    • Tovmasyan, Artak, Ivan Spasojevic, Huaxin Sheng, Qingfu Zhang, Jiaoti Huang, Bridget Koontz, and Ines Batinic-Haberle. “Protection of rat prostate and erectile function from radiation-induced damage by novel Mn(III) N - substituted pyridylporphyrin and ascorbate.” In Free Radical Biology and Medicine, 112:35–36. Elsevier BV, 2017. https://doi.org/10.1016/j.freeradbiomed.2017.10.045.
       Full Text
    • Tovmasyan, Artak, Jacqueline C. Bueno-Janice, Ivan Spasojevic, and Ines Batinic-Haberle. “Novel fluorinated Mn porphyrin as a powerful SOD mimic and catalyst for ascorbate-coupled anticancer therapy.” In Free Radical Biology and Medicine, 112:36–37. Elsevier BV, 2017. https://doi.org/10.1016/j.freeradbiomed.2017.10.046.
       Full Text
    • Yao, Zhong-Ke, Suzanne Wardell, Ivan Spasojevic, John Norris, John Katzenellenbogen, Donald McDonnell, and Jatinder Josan. “Discovery of a selective androgen receptor degrader (SARD) for treatment of castration-resistant prostate cancer.” In Abstracts of Papers of the American Chemical Society, Vol. 254. AMER CHEMICAL SOC, 2017.
       Link to Item
    • Becher, Oren J., Stephen W. Gilheeney, Yasmin Khakoo, David C. Lyden, Sofia Haque, Kevin C. De Braganca, Jill M. Kolesar, et al. “A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors.” In Pediatr Blood Cancer, Vol. 64, 2017. https://doi.org/10.1002/pbc.26409.
       Full Text  Link to Item
    • Becher, O. J., N. E. Millard, S. Modak, B. H. Kushner, S. Haque, I. Spasojevic, T. M. Trippett, et al. “A phase i study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.” In Plos One, Vol. 12, 2017. https://doi.org/10.1371/journal.pone.0178593.
       Full Text
    • Brousell, Steven C., Thomas A. Longo, Joseph J. Fantony, Wiguins Etienne, David Needham, Mark W. Dewhirst, Paolo F. Maccarini, Ivan Spasojevic, and Brant A. Inman. “MP65-08 HEAT-TARGETED DRUG DELIVERY USING THE COMBAT BRS DEVICE FOR TREATING BLADDER CANCER.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.2002.
       Full Text
    • Tovmasyan, Artak, Jacqueline C. Bueno-Janice, Julio S. Reboucas, Ivan Spasojevic, and Ines Batinic-Haberle. “Redox-Active Mn Porphyrins, MnTE-2-PyP5+ and MnTnBuOE-2-PyP5+ But Not Redox-Inert MnTBAP3-Suppress Tumor Growth in an Environment Where H2O2 Is Produced.” In Free Radical Biology and Medicine, 100:S93–S93. Elsevier BV, 2016. https://doi.org/10.1016/j.freeradbiomed.2016.10.232.
       Full Text
    • Tovmasyan, Artak, Young-Mi Go, Dean Jones, Ivan Spasojevic, and Ines Batinic-Haberle. “Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP5+/Ascorbate System.” In Free Radical Biology and Medicine, 100:S112–13. Elsevier BV, 2016. https://doi.org/10.1016/j.freeradbiomed.2016.10.290.
       Full Text
    • Gad, Shayne Cox, Dexter W. Sullivan, Ivan Spasojevic, Cesar V. Mujer, Charles B. Spainhour, and James D. Crapo. “Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001).” In Int J Toxicol, 35:438–53, 2016. https://doi.org/10.1177/1091581816642766.
       Full Text  Link to Item
    • Whitley, Melodi J., Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, et al. “Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents.” In Cancer Research, Vol. 75. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-sy36-03.
       Full Text
    • Vadhan-Raj, Saroj, Vinod Ravi, Xiao Zhou, Dejka M. Araujo, Neeta Somaiah, Anthony Paul Conley, Mary Daniel, Robert S. Benjamin, Shreyaskumar Patel, and Ivan Spasojevic. “Effects of fosaprepitan (Fosa) on ifosfamide (Ifex) metabolism in sarcoma patients (pts) receiving multi-day chemotherapy (CT) regimen on doxorubicin (Dox) and Ifex (AI): Randomized, cross-over study.” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.
       Link to Item
    • Lee, Chen-Ting, Aaron Blackley, Chelsea Landon, Ivan Spasojevic, John P. Kirkpatrick, and Mark W. Dewhirst. “Abstract 3774: Hyperthermia treatment overcomes temozolomide resistance in glioma cells by downregulating MGMT expression and increasing temozolomide uptake.” In Cancer Research, 74:3774–3774. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-3774.
       Full Text
    • Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.
       Full Text
    • Base, Karel, Willem W. Lombard, Jorn Karhausen, Huaxin Sheng, and Ivan Spasojevic. “Quantification of Tetrahydrobiopterin (BH4), Dihydrobiopterin (BH2) and Biopterin (BP) in Mouse Brain and Intestines After Ischemic Injury by Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ESI-MS/MS).” In Free Radical Biology and Medicine, 53:S16–S16. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.032.
       Full Text
    • Tovmasyan, Artak, Tin Weitner, Emily Roberts, Melba Jaramillo, Ivan Spasojevic, Kam Leong, Margaret Tome, Ludmil Benov, and Ines Batinic-Haberle. “Understanding Differences in Mechanisms of Action of Fe vs Mn Porphyrins: Comparison of Their Reactivities Towards Cellular Reductants and Reactive Species.” In Free Radical Biology and Medicine, 53:S120–S120. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.297.
       Full Text
    • Weitner, Tin, Huaxin Sheng, Sumitra Miriyala, David Leu, Artak Tovmasyan, Ivan Kos, Julio S. Reboucas, et al. “Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution.” In Free Radical Biology and Medicine, 53:S118–S118. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.291.
       Full Text
    • Batinic-Haberle, Ines, and Ivan Spasojevic. “Structure-activity and bioavailability studies drive development of cationic Mn porphyrins as cancer and central nervous system therapeutics.” In Abstracts of Papers of the American Chemical Society, Vol. 244. AMER CHEMICAL SOC, 2012.
       Link to Item
    • Ludeman, Susan M., Michael A. D’Alessandro, R Stephanie Huang, Ivan Spasojevic, and M Eileen Dolan. “Abstract 4766: The use of deuterium isotope effects to shift the partitioning of cyclophosphamide and ifosfamide among competing, P450-dependent, oxidative pathways.” In Cancer Research, 72:4766–4766. American Association for Cancer Research (AACR), 2012. https://doi.org/10.1158/1538-7445.am2012-4766.
       Full Text
    • Vadhan-Raj, Saroj, Ivan Spasojevic, Xiao Zhou, Jorge E. Romaguera, Michelle A. Fanale, Luis E. Fayad, Nathan H. Fowler, et al. “Effects of Aprepitant on Drug Metabolism in Lymphoma Patients Receiving Multi-Day Chemotherapy Regimen of Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, plus Rituxan (R/CHOP): Randomized, Cross-Over Study.” In Blood, 118:702–702. AMER SOC HEMATOLOGY, 2011.
       Link to Item
    • Il’yasova, Dora, Ivan Spasojevic, Karel Base, Frances Wang, Ralph B. D’Agostino, and Lynne Wagenknecht. “Racial Differences in Urinary F2-isoprostanes May Reflect Weak Metabolic Adaptation in African Americans.” In Free Radical Biology and Medicine, 51:S62–S62. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.160.
       Full Text
    • Rajic, Zrinka, Artak Tovmasyan, Alice M. Li, Edith B. Gralla, Huaxin Sheng, David S. Warner, Ludmil Benov, Ivan Spasojevic, and Ines Batinic-Haberle. “A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties.” In Free Radical Biology and Medicine, 51:S95–S95. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.462.
       Full Text
    • Reboucas, Julio S., Zrinka Rajic, Artak Tovmasyan, Isabelle N. Peixoto, Ivan Spasojevic, Ludmil Benov, Elizete Ventura, Silmar A. do Monte, and Ines Batinic-Haberle. “Experimental and Computational Studies on Mn Porphyrin-Based Therapeutics: Unforeseen Intramolecular Rearrangements on Methoxyalkyl Analogues of MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” In Free Radical Biology and Medicine, 51:S148–49. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.256.
       Full Text
    • Spasojevic, Ivan, Sumitra Miriyala, Artak Tovmasyan, Daniela Salvemini, Ping Fan, Zeljko Vujaskovic, Ines Batinic-Haberle, and Daret K St Clair. “Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study.” In Free Radical Biology and Medicine, 51:S98–99. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.473.
       Full Text
    • Tovmasyan, Artak, Tin Weitner, Ivan Spasojevic, Zrinka Rajic, Ludmil Benov, and Ines Batinic-Haberle. “Fe porphyrins Revisited: Synthesis, Characterization and the Effects of Ortho and Meta Fe(III) N-Alkylpyridylporphyrins Upon the Growth of E. Coli in the Presence and Absence of Ascorbate.” In Free Radical Biology and Medicine, 51:S99–S99. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.475.
       Full Text
    • yasova, Dora ll’, Pao-Hwa Lin, Laura Svetkey, William Kraus, Ivan Spasojevic, Karel Base, Frances Wang, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Cross-sectional and Prospective Associations Between Urinary F2-Isoprostanes and Blood Pressure in the IRAS Cohort.” In Free Radical Biology and Medicine, 51:S44–S44. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.110.
       Full Text
    • Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “METABOLOMIC PROFILING OF A GLIOMA CELL LINE EXPRESSING IDH1 AND IDH2 MUTANTS.” In Neuro Oncology, 13:I22–23. OXFORD UNIV PRESS INC, 2011.
       Link to Item
    • Yan, Hai, Zachary J. Reitman, Genglin Jin, Ivan Spasojevic, Yiping He, Dare D. Bigner, Edward D. Karoly, Jian Yang, Kenneth W. Kinzler, and Bert Vogelstein. “Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome.” In Cancer Research, Vol. 71, 2011. https://doi.org/10.1158/1538-7445.AM2011-LB-257.
       Full Text  Link to Item
    • Base, Karel, Frederick W. Lombard, Lee Jones, Dora Il’yasova, and Ivan Spasojevic. “Quantification of Selected F2Isoprostanes and Creatinine in Human Urine by Liquid Chromatographyelectrospray Tandem Mass Spectrometry (LCESIMS/MS).” In Free Radical Biology and Medicine, 49:S162–S162. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.455.
       Full Text
    • Dogan, Serdar, Katarzyna Baranowska, Monika Walankiewicz, Piraye Yargicoglu, Mustafa Unal, Ivan Spasojevic, Ines Batinic Haberle, and Mutay Aslan. “Manganese Porphyrin Reduces Retinal Injury Induced by Ocular Hypertension.” In Free Radical Biology and Medicine, 49:S176–77. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.501.
       Full Text
    • Il’yasova, Dora, Ivan Spasojevic, Karel Base, Adviye Tolun, Haoyue Zhang, Frances Wang, Sarah Young, David Millington, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Systemic Markers of Oxidative Status and the Risk of Type 2 Diabetes.” In Free Radical Biology and Medicine, 49:S38–S38. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.076.
       Full Text
    • Il’yasova, Dora, Sharareh Reihani, Ivan Spasojevic, Karel Base, Adviye Tolun, Frances Wang, Sarah Young, David Millington, and Ralph B. D Agostino. “Association between Systemic Markers of Oxidative Status and the Risk of Colorectal Adenoma Polyps.” In Free Radical Biology and Medicine, 49:S68–S68. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.166.
       Full Text
    • Spasojevic, Ivan, Alice Li, Artak Tovmasyan, Zrinka Rajic, Daniela Salvemini, Daret St. Clair, Joan Selverstone Valentine, Zeljko Vujaskovic, Edith B. Gralla, and Ines Batinic-Haberle. “Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins.” In Free Radical Biology and Medicine, 49:S199–S199. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.576.
       Full Text
    • Tovmasyan, Artak, Zrinka Rajic, Ivan Spasojevic, Julio Reboucas, Huaxin Sheng, David S. Warner, Alice Li, Edith B. Gralla, Ludmil Benov, and Ines Batinic-Haberle. “Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies.” In Free Radical Biology and Medicine, 49:S201–S201. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.583.
       Full Text
    • Kos, Ivan, Ludmil Benov, Ivan Spasojevic, Julio S. Reboucas, and Ines Batinic-Haberle. “Increased Lipophilicity of meta Mn(III) N-alkylpyridylporphyrins, when Compared to ortho isomers, Fully Compensates for their Lower SOD-like Activity when Protecting SOD-deficient E. coli.” In Free Radical Biology and Medicine, 47:S150–51. ELSEVIER SCIENCE INC, 2009.
       Link to Item
    • Reboucas, Julio S., Ivan Kos, Ludmil Benov, Ivan Spasojevic, and Ines Batinic-Haberle. “Lipophilicity of Potent Mn Porphyrin-based SOD and Peroxynitrite Reductase Mimics is Redox Modulated.” In Free Radical Biology and Medicine, 47:S151–S151. ELSEVIER SCIENCE INC, 2009.
       Link to Item
    • Il’yasova, Dora, Ivan Spasojevic, Frances Wang, Adviye Tolun, Karel Base, Sarah Young, P Kelly Marcom, et al. “How to Measure Oxidative Status in Humans? Part II.” In Free Radical Biology and Medicine, 47:S170–S170. ELSEVIER SCIENCE INC, 2009.
       Link to Item
    • Salvemini, Daniela, Ines Batini-Haberle, Salvatore Cuzzocrea, Julio Reboucas, Emanuela Masini, George Matuschak, and Ivan Spasojevic. “Peroxynitrite Decomposition Catalysts as Adjuncts to Morphine for the Management of Chronic Pain States.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.
       Link to Item
    • Salvemini, Daniela, Ines Batinic-Haberle, Michael M. Ndengele, Salvatore Cuzzocrea, Julio S. Reboucas, and Ivan Spasojevic. “Lipophilicity Is a Critical Parameter That Dominates the Efficacy of Metalloporphyrins in Blocking the Development of Morphine Antinociceptive Tolerance Through Peroxynitrite Mediated Pathways.” In Free Radical Biology and Medicine, 45:S106–S106. ELSEVIER SCIENCE INC, 2008.
       Link to Item
    • Kos, Ivan, Julio S. Reboucas, Huaxin Sheng, David S. Warner, Ivan Spasojevic, and Ines Batinic-Haberle. “Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator.” In Free Radical Biology and Medicine, 45:S86–87. ELSEVIER SCIENCE INC, 2008.
       Link to Item
    • Rebducas, Julio S., Gilson de F. Silva, Ivan Spasojevic, Ynara M. Idemori, Ludmil Benov, and Ines Batinic-Haberle. “Recent advances in understanding structure-activity relationships of Mn porphyrin-based therapeutics: Charge distribution and electrostatic effects.” In Free Radical Biology and Medicine, 43:S26–S26. ELSEVIER SCIENCE INC, 2007.
       Link to Item
    • Reboucas, Julio S., Ivan Spasojevic, and Ines Batinic-Haberle. “Pure MnTBAP is not a superoxide dismutase mimic in aqueous systems: A case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology.” In Free Radical Biology and Medicine, 43:S26–S26. ELSEVIER SCIENCE INC, 2007.
       Link to Item
    • Vlahovic, Gordana, Zahid Rabbani, Ivan Spasojevic, Larisa Zgonjanin, Mark W. Dewhirst, and Zeljko Vujaskovic. “Treatment with gleevec in NSCLC xenografts decreases proliferative capillary index and improves drug delivery.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
       Link to Item
    • Spasojevic, Ivan, and Ines Batinic-Haberle. “Metalloporphyrins mimic cyt P450 in activating cyclophosphamide in biologically relevant system.” In Free Radical Biology and Medicine, 41:S106–S106. ELSEVIER SCIENCE INC, 2006.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.