The channel of death.


Journal Article

The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.

Full Text

Duke Authors

Cited Authors

  • Degterev, A; Boyce, M; Yuan, J

Published Date

  • November 26, 2001

Published In

Volume / Issue

  • 155 / 5

Start / End Page

  • 695 - 698

PubMed ID

  • 11724809

Pubmed Central ID

  • 11724809

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.200110147


  • eng

Conference Location

  • United States