https://orcid.org/0000-0002-2729-4876
Overview
The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.
Current Appointments & Affiliations
Associate Professor of Biochemistry
·
2019 - Present
Biochemistry,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2014 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Dynamic O-GlcNAcylation of Sec23-interacting protein regulates COPII function.
Journal Article bioRxiv · December 20, 2025 About one-third of the eukaryotic proteome transits the secretory pathway to reach its correct cellular or extracellular destination. At the earliest stage, transport from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment (ERGIC) or G ... Full text Link to item CiteEvidence for functional regulation of the KLHL3/WNK pathway by O-GlcNAcylation.
Journal Article Glycobiology · August 11, 2025 The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human d ... Full text Link to item CiteDynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression.
Journal Article J Biol Chem · August 2025 During mitosis, eukaryotic cells cease anterograde trafficking from the endoplasmic reticulum (ER) toward the Golgi. This cessation corresponds with the dispersal of the COPII transport protein, Sec24C, from juxtanuclear ER exit sites (ERES) into a diffuse ... Full text Link to item CiteRecent Grants
Cell signaling through O-linked glycosylation
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program
ResearchPreceptor · Awarded by National Cancer Institute · 2023 - 2028View All Grants
Education
Harvard Medical School ·
2005
Ph.D.