Overview
The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.
Current Appointments & Affiliations
Associate Professor of Biochemistry
·
2019 - Present
Biochemistry,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2014 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Evidence for functional regulation of the KLHL3/WNK pathway by O-GlcNAcylation.
Journal Article Glycobiology · August 11, 2025 The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human d ... Full text Link to item CiteDynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression.
Journal Article J Biol Chem · August 2025 During mitosis, eukaryotic cells cease anterograde trafficking from the endoplasmic reticulum (ER) toward the Golgi. This cessation corresponds with the dispersal of the COPII transport protein, Sec24C, from juxtanuclear ER exit sites (ERES) into a diffuse ... Full text Link to item CiteDynamic regulation of the COPII interactome and collagen trafficking by site-specific glycosylation of Sec24D.
Journal Article bioRxiv · June 13, 2025 Coat protein complex II (COPII) mediates anterograde trafficking from the endoplasmic reticulum (ER). While the core COPII machinery is well-characterized, how cells regulate COPII to accommodate large cargoes, including collagens, remains incompletely und ... Full text Link to item CiteRecent Grants
Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program
ResearchPreceptor · Awarded by National Cancer Institute · 2023 - 2028Cell signaling through O-GlcNAc reader proteins
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2016 - 2027View All Grants
Education, Training & Certifications
Harvard Medical School ·
2005
Ph.D.