Role of G12 proteins in oncogenesis and metastasis.

Journal Article (Journal Article;Review)

The G12 subfamily of heterotrimeric guanine nucleotide-binding proteins consists of two alpha subunits, G alpha12 and G alpha13. These proteins mediate signalling via G protein-coupled receptors and have been implicated in various physiological and pathophysiological processes. A number of direct and indirect effectors of G alpha12 and G alpha13 have been identified that mediate, or have been proposed to mediate, the diverse cellular responses accompanying activation of G12 proteins. This review describes the signalling pathways and cellular events stimulated by G12 proteins, with a particular emphasis on processes that are important in regulating cell migration and invasion, and could potentially be involved in the pathophysiology of cancer metastasis. Experimental findings directly implicating G12 proteins in the spread of metastatic disease are also summarized, indicating the importance of targeted inhibition of G12 signalling as a potential therapeutic option for locally advanced and metastatic disease.

Full Text

Duke Authors

Cited Authors

  • Juneja, J; Casey, PJ

Published Date

  • September 2009

Published In

Volume / Issue

  • 158 / 1

Start / End Page

  • 32 - 40

PubMed ID

  • 19422395

Pubmed Central ID

  • PMC2795253

Electronic International Standard Serial Number (EISSN)

  • 1476-5381

Digital Object Identifier (DOI)

  • 10.1111/j.1476-5381.2009.00180.x


  • eng

Conference Location

  • England