Patrick John Casey
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology
Research in this laboratory focuses on the area of transmembrane signaling mediated through guanine nucleotide-binding regulatory proteins (G proteins). Many of these signaling pathways are involved in control of cell growth; this property is highlighted by discoveries over the past decade that mutations in G proteins can lead to cell transformation. There are two major areas of research ongoing in the lab. The first is the covalent modification of G proteins by isoprenoid lipids and the role this modification, termed protein prenylation, plays in the membrane targeting and function of G proteins. Prenylation plays a crucial role oncogenic transformation by one class of G proteins, the Ras proteins. The enzymes that catalyze these modifications have been isolated and cloned and are being used to develop in vitro systems to both define the enzymes’ structures and molecular mechanisms and elucidate the role of prenylation in G protein function. The importance of this work is highlighted by the fact that several of these enzymes, most notably protein farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase-1), a prenyl protein-specific protease termed Rce1, and a specific methyltransferase termed Icmt have become major targets in the development of anti-cancer therapeutics.
The second general area of research involves identification of the signaling pathways controlled by specific types of G proteins. One such protein, termed Gz, exhibits very limited tissue distribution that includes primarily neuronal and neuroendocrine cells. Gz exhibits several biochemical properties that suggest that this protein controls a unique signaling pathway, and we have recently linked Gz to control of important aspects of pancreatic beta-cell function. We have also have a program to identify molecular targets of G12 proteins. We have linked the G12 proteins to cell-surface cadherins and to activation of the GTPase Rho, and have obtained evidence that activation of G12 impacts on the cellular processes of of adhesion and migration and that aberrant activation of G12 contributes to metastatic progression of breast and prostate cancer.
The second general area of research involves identification of the signaling pathways controlled by specific types of G proteins. One such protein, termed Gz, exhibits very limited tissue distribution that includes primarily neuronal and neuroendocrine cells. Gz exhibits several biochemical properties that suggest that this protein controls a unique signaling pathway, and we have recently linked Gz to control of important aspects of pancreatic beta-cell function. We have also have a program to identify molecular targets of G12 proteins. We have linked the G12 proteins to cell-surface cadherins and to activation of the GTPase Rho, and have obtained evidence that activation of G12 impacts on the cellular processes of of adhesion and migration and that aberrant activation of G12 contributes to metastatic progression of breast and prostate cancer.
Current Appointments & Affiliations
- James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2002
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1999
- Director of the Center for Chemical Biology, Pharmacology & Cancer Biology, Basic Science Departments 1999
- Professor of Biochemistry, Biochemistry, Basic Science Departments 1999
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1990
Contact Information
- C133 Lev Sci Res Ctr, Durham, NC 27708
- Duke Box 3813, Durham, NC 27710
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casey006@mc.duke.edu
(919) 613-8612
- Background
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Education, Training, & Certifications
- Ph.D., Brandeis University 1987
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Previous Appointments & Affiliations
- Senior Vice Dean for Research, National University of Singapore-Duke Graduate Medical School, School of Medicine, Duke University 2005 - 2007
- Associate Professor of Biochemistry, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 1996 - 1999
- Associate Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 1997 - 1999
- Associate Professor of Molecular Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 1995 - 1997
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 1994 - 1996
- Assistant Professor of Molecular Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 1995
- Recognition
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In the News
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Awards & Honors
- Research
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Selected Grants
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- G(alpha)Z signaling in insulin secretion and glucose tolerance awarded by National Institutes of Health 2008 - 2010
- Nonclassical signaling of the androgen receptor polyproline domain awarded by National Institutes of Health 2009 - 2010
- Regulation of G-Protein Signaling awarded by National Institutes of Health 1998 - 2010
- Innovative Assays for Oncogenic Hedgehog Signaling awarded by National Institutes of Health 2006 - 2010
- G Protein Involvement in Oncogenesis and Metastasis awarded by National Institutes of Health 2004 - 2009
- Developing inhibitors of RalA function for the treatment of pancreatic cancer awarded by National Institutes of Health 2007 - 2009
- Biomarker Studies for Novel Anti-Cancer Agents awarded by National Institutes of Health 2003 - 2008
- Same awarded by National Institutes of Health 1998 - 2007
- Structure and Function of ICMT Methyltransferase awarded by National Institutes of Health 2004 - 2007
- Role of G(alpha)Z in Pancreatic Islet Beta-cell Biology awarded by National Institutes of Health 2004 - 2006
- Cancer Biology Training Grant awarded by National Institutes of Health 1993 - 2005
- Interaction of Galpha12 with cadherin in oncogenesis awarded by National Institutes of Health 2001 - 2004
- Regulation Of Cyclic Gmp Phosphodiesterase By Gz awarded by National Institutes of Health 1997 - 2001
- Regulation Of G Protein Mediated Signaling awarded by National Institutes of Health 1997 - 1999
- Biology Of The Testis awarded by National Institutes of Health 1997 - 1999
- Molecular Mechanisms Of Protein Prenylation awarded by National Institutes of Health 1996 - 1998
- Mechanism Of Pkc Regulation awarded by National Institutes of Health 1995
- Molecular Mechanisms Of Protein Prenylation awarded by National Science Foundation 1991 - 1995
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External Relationships
- Legend Biotech
- National Research Foundation, Singapore
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Karthikeyan, Subbulakshmi, Patrick J. Casey, and Mei Wang. “RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.” Breast Cancer Res 24, no. 1 (October 28, 2022): 72. https://doi.org/10.1186/s13058-022-01564-6.Full Text Link to Item
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Rasheed, Suhail Ahmed Kabeer, Lalitha Vaishnavi Subramanyan, Wei Kiang Lim, Udhaya Kumari Udayappan, Mei Wang, and Patrick J. Casey. “The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors.” Oncogene 41, no. 2 (January 2022): 147–58. https://doi.org/10.1038/s41388-021-02069-w.Full Text
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Tang, Jingyi, Patrick J. Casey, and Mei Wang. “Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair.” Life Sci Alliance 4, no. 12 (December 2021). https://doi.org/10.26508/lsa.202101144.Full Text Link to Item
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Lau, Hiu Yeung, Jingyi Tang, Patrick J. Casey, and Mei Wang. “Evaluating the Epithelial-Mesenchymal Program in Human Breast Epithelial Cells Cultured in Soft Agar Using a Novel Macromolecule Extraction Protocol.” Cancers (Basel) 13, no. 4 (February 15, 2021). https://doi.org/10.3390/cancers13040807.Full Text Link to Item
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Chai, Tin Fan, Kanjoormana Aryan Manu, Patrick J. Casey, and Mei Wang. “Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.” Oncogene 39, no. 31 (July 2020): 5373–89. https://doi.org/10.1038/s41388-020-1364-7.Full Text Link to Item
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Lim, Wei Kiang, Xiaoran Chai, Sujoy Ghosh, Debleena Ray, Mei Wang, Suhail Ahmed Kabeer Rasheed, and Patrick J. Casey. “Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.” J Biol Chem 294, no. 48 (November 29, 2019): 18192–206. https://doi.org/10.1074/jbc.RA119.010018.Full Text Link to Item
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Manu, Kanjoormana Aryan, Pham Hong Anh Cao, Tin Fan Chai, Patrick J. Casey, and Mei Wang. “p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress.” Cancers (Basel) 11, no. 8 (August 3, 2019). https://doi.org/10.3390/cancers11081112.Full Text Link to Item
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Teh, Jing Tsong, Wan Long Zhu, Christopher B. Newgard, Patrick J. Casey, and Mei Wang. “Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.” Mol Cancer Ther 18, no. 3 (March 2019): 693–705. https://doi.org/10.1158/1535-7163.MCT-18-0766.Full Text Link to Item
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Rasheed, Suhail Ahmed Kabeer, Hui Sun Leong, Manikandan Lakshmanan, Anandhkumar Raju, Dhivya Dadlani, Fui-Teen Chong, Nicholas B. Shannon, et al. “GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.” Oncogene 37, no. 10 (March 2018): 1340–53. https://doi.org/10.1038/s41388-017-0038-6.Full Text Link to Item
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Do, M. T., T. F. Chai, P. J. Casey, and M. Wang. “Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.” Oncogene 36, no. 41 (October 12, 2017): 5757–67. https://doi.org/10.1038/onc.2017.183.Full Text Link to Item
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Lau, H. Y., J. Tang, P. J. Casey, and M. Wang. “Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.” Oncogene 36, no. 27 (July 6, 2017): 3934–42. https://doi.org/10.1038/onc.2016.508.Full Text Link to Item
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Manu, Kanjoormana Aryan, Tin Fan Chai, Jing Tsong Teh, Wan Long Zhu, Patrick J. Casey, and Mei Wang. “Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.” Mol Cancer Ther 16, no. 5 (May 2017): 914–23. https://doi.org/10.1158/1535-7163.MCT-16-0703.Full Text Link to Item
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Udayappan, Udhaya Kumari, and Patrick J. Casey. “c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.” Molecules 22, no. 4 (April 10, 2017). https://doi.org/10.3390/molecules22040612.Full Text Link to Item
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Ng, Mei Ying, Mei Wang, Patrick J. Casey, Yunn-Hwen Gan, and Thilo Hagen. “Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).” Plos One 12, no. 2 (2017): e0171464. https://doi.org/10.1371/journal.pone.0171464.Full Text Link to Item
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Teo, Cui Rong, Patrick J. Casey, and Suhail Ahmed Kabeer Rasheed. “The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.” Cell Signal 28, no. 10 (October 2016): 1479–88. https://doi.org/10.1016/j.cellsig.2016.07.001.Full Text Link to Item
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Healy, Jane A., Adrienne Nugent, Rachel E. Rempel, Andrea B. Moffitt, Nicholas S. Davis, Xiaoyu Jiang, Jennifer R. Shingleton, et al. “GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.” Blood 127, no. 22 (June 2, 2016): 2723–31. https://doi.org/10.1182/blood-2015-07-659938.Full Text Link to Item
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Sun, Wen Tian, Wei Xiang, Bee Ling Ng, Kartini Asari, Ralph M. Bunte, Patrick J. Casey, Mei Wang, and Charles Chuah. “Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.” Exp Hematol 44, no. 3 (March 2016): 189-93.e2. https://doi.org/10.1016/j.exphem.2015.12.002.Full Text Link to Item
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Wang, Mei, and Patrick J. Casey. “Protein prenylation: unique fats make their mark on biology.” Nat Rev Mol Cell Biol 17, no. 2 (February 2016): 110–22. https://doi.org/10.1038/nrm.2015.11.Full Text Link to Item
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Ullah, Nisar, Muhammad Mansha, and Patrick J. Casey. “Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.” Curr Cancer Drug Targets 16, no. 7 (2016): 563–71. https://doi.org/10.2174/1568009616666151203224603.Full Text Link to Item
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Teh, J. T., W. L. Zhu, O. R. Ilkayeva, Y. Li, J. Gooding, P. J. Casey, S. A. Summers, C. B. Newgard, and M. Wang. “Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.” Oncogene 34, no. 25 (June 2015): 3296–3304. https://doi.org/10.1038/onc.2014.260.Full Text Link to Item
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Rasheed, Suhail Ahmed Kabeer, Cui Rong Teo, Emmanuel Jean Beillard, P Mathijs Voorhoeve, Wei Zhou, Sujoy Ghosh, and Patrick J. Casey. “MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.” Mol Cancer 14 (March 26, 2015): 67. https://doi.org/10.1186/s12943-015-0337-x.Full Text Link to Item
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Lau, Hiu Yeung, Pondy M. Ramanujulu, Dianyan Guo, Tianming Yang, Melissa Wirawan, Patrick J. Casey, Mei-Lin Go, and Mei Wang. “An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.” Cancer Biol Ther 15, no. 9 (September 2014): 1280–91. https://doi.org/10.4161/cbt.29692.Full Text Link to Item
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Kimple, Michelle E., Joshua C. Neuman, Amelia K. Linnemann, and Patrick J. Casey. “Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.” Exp Mol Med 46, no. 6 (June 20, 2014): e102. https://doi.org/10.1038/emm.2014.40.Full Text Link to Item
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Chia, Crystal Y., Udhaya Kumari, and Patrick J. Casey. “Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.” J Mol Signal 9 (2014): 6. https://doi.org/10.1186/1750-2187-9-6.Full Text Link to Item
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Hultman, Rainbo, Udhaya Kumari, Nadine Michel, and Patrick J. Casey. “Gαz regulates BDNF-induction of axon growth in cortical neurons.” Mol Cell Neurosci 58 (January 2014): 53–61. https://doi.org/10.1016/j.mcn.2013.12.004.Full Text Link to Item
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Cushman, Ian, Stephanie M. Cushman, Philip M. Potter, and Patrick J. Casey. “Control of RhoA methylation by carboxylesterase I.” J Biol Chem 288, no. 26 (June 28, 2013): 19177–83. https://doi.org/10.1074/jbc.M113.467407.Full Text Link to Item
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Ramanujulu, Pondy M., Tianming Yang, Siew-Qi Yap, Fui-Chung Wong, Patrick J. Casey, Mei Wang, and Mei-Lin Go. “Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).” Eur J Med Chem 63 (May 2013): 378–86. https://doi.org/10.1016/j.ejmech.2013.02.007.Full Text Link to Item
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Zhu, Y., P. J. Casey, A. P. Kumar, and S. Pervaiz. “Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.” Cell Death Dis 4, no. 4 (April 4, 2013): e568. https://doi.org/10.1038/cddis.2013.103.Full Text Link to Item
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Zhu, Y., P. J. Casey, A. P. Kumar, and S. Pervaiz. “Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases.” Cell Death and Disease 4, no. 4 (April 1, 2013). https://doi.org/10.1038/cddis.2013.103.Full Text
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Rasheed, Suhail Ahmed Kabeer, Cui Rong Teo, Emmanuel Jean Beillard, P Mathijs Voorhoeve, and Patrick J. Casey. “MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.” J Biol Chem 288, no. 11 (March 15, 2013): 7986–95. https://doi.org/10.1074/jbc.M112.437749.Full Text Link to Item
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Kimple, Michelle E., Jennifer B. Moss, Harpreet K. Brar, Taylor C. Rosa, Nathan A. Truchan, Renee L. Pasker, Christopher B. Newgard, and Patrick J. Casey. “Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.” J Biol Chem 287, no. 24 (June 8, 2012): 20344–55. https://doi.org/10.1074/jbc.M112.359745.Full Text Link to Item
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Zhu, Wan Long, Mohammed S. Hossain, Dian Yan Guo, Sen Liu, Honglian Tong, Atefeh Khakpoor, Patrick J. Casey, and Mei Wang. “A role for Rac3 GTPase in the regulation of autophagy.” J Biol Chem 286, no. 40 (October 7, 2011): 35291–98. https://doi.org/10.1074/jbc.M111.280990.Full Text Link to Item
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Dasgupta, Subhamoy, Ian Cushman, Marilyne Kpetemey, Patrick J. Casey, and Jamboor K. Vishwanatha. “Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis.” J Biol Chem 286, no. 29 (July 22, 2011): 25935–46. https://doi.org/10.1074/jbc.M111.254599.Full Text Link to Item
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Forrester, Michael T., Douglas T. Hess, J Will Thompson, Rainbo Hultman, M Arthur Moseley, Jonathan S. Stamler, and Patrick J. Casey. “Site-specific analysis of protein S-acylation by resin-assisted capture.” J Lipid Res 52, no. 2 (February 2011): 393–98. https://doi.org/10.1194/jlr.D011106.Full Text Link to Item
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Hightower, K. E., and P. J. Casey. “The Enzymology of CAAX Protein Prenylation” 30 (January 1, 2011): 1–11. https://doi.org/10.1016/B978-0-12-415922-8.00001-X.Full Text
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Juneja, Juhi, Ian Cushman, and Patrick J. Casey. “G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.” Plos One 6, no. 11 (2011): e26085. https://doi.org/10.1371/journal.pone.0026085.Full Text Link to Item
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Cushman, Ian, and Patrick J. Casey. “RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.” Cell Adh Migr 5, no. 1 (2011): 11–15. https://doi.org/10.4161/cam.5.1.13196.Full Text Link to Item
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Go, Mei-Lin, Jo Lene Leow, Suresh Kumar Gorla, Andreas Peter Schüller, Mei Wang, and Patrick J. Casey. “Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.” J Med Chem 53, no. 19 (October 14, 2010): 6838–50. https://doi.org/10.1021/jm1002843.Full Text Link to Item
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Wang, M., M. S. Hossain, W. Tan, B. Coolman, J. Zhou, S. Liu, and P. J. Casey. “Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.” Oncogene 29, no. 35 (September 2, 2010): 4959–70. https://doi.org/10.1038/onc.2010.247.Full Text Link to Item
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Mizrahi, Ariel, Yevgeny Berdichevsky, Patrick J. Casey, and Edgar Pick. “A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.” J Biol Chem 285, no. 33 (August 13, 2010): 25485–99. https://doi.org/10.1074/jbc.M110.113779.Full Text Link to Item
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Kelly, Patrick, Candice L. Bailey, Patrick T. Fueger, Christopher B. Newgard, Patrick J. Casey, and Michelle E. Kimple. “Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.” J Biol Chem 285, no. 21 (May 21, 2010): 15777–85. https://doi.org/10.1074/jbc.M109.069112.Full Text Link to Item
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Doughty-Shenton, Dahlia, James D. Joseph, Ji Zhang, David J. Pagliarini, Youngjun Kim, Danhong Lu, Jack E. Dixon, and Patrick J. Casey. “Pharmacological targeting of the mitochondrial phosphatase PTPMT1.” J Pharmacol Exp Ther 333, no. 2 (May 2010): 584–92. https://doi.org/10.1124/jpet.109.163329.Full Text Link to Item
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Kimple, M. E., R. C. Hultman, and P. J. Casey. “Signaling through Gz.” Handbook of Cell Signaling, 2/E 2 (2010): 1649–53. https://doi.org/10.1016/B978-0-12-374145-5.00202-3.Full Text
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Rossol-Allison, Jessica, Laura N. Stemmle, Katherine I. Swenson-Fields, Patrick Kelly, Patrick E. Fields, Shannon J. McCall, Patrick J. Casey, and Timothy A. Fields. “Rho GTPase activity modulates Wnt3a/beta-catenin signaling.” Cell Signal 21, no. 11 (November 2009): 1559–68. https://doi.org/10.1016/j.cellsig.2009.05.010.Full Text Link to Item
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Cushman, Ian, and Patrick J. Casey. “Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.” J Biol Chem 284, no. 41 (October 9, 2009): 27964–73. https://doi.org/10.1074/jbc.M109.025296.Full Text Link to Item
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Juneja, Juhi, and Patrick J. Casey. “Role of G12 proteins in oncogenesis and metastasis.” Br J Pharmacol 158, no. 1 (September 2009): 32–40. https://doi.org/10.1111/j.1476-5381.2009.00180.x.Full Text Link to Item
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Peterson, Yuri K., Xiang S. Wang, Patrick J. Casey, and Alexander Tropsha. “Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.” J Med Chem 52, no. 14 (July 23, 2009): 4210–20. https://doi.org/10.1021/jm8013772.Full Text Link to Item
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Bailey, Candice L., Patrick Kelly, and Patrick J. Casey. “Activation of Rap1 promotes prostate cancer metastasis.” Cancer Res 69, no. 12 (June 15, 2009): 4962–68. https://doi.org/10.1158/0008-5472.CAN-08-4269.Full Text Link to Item
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Wright, Latasha P., Helen Court, Adam Mor, Ian M. Ahearn, Patrick J. Casey, and Mark R. Philips. “Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.” Mol Cell Biol 29, no. 7 (April 2009): 1826–33. https://doi.org/10.1128/MCB.01719-08.Full Text Link to Item
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Wang, Mei, Yok Moi Khoo, Jin Zhou, Patrick Casey, and How Sung Lee. “A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma.” J Chromatogr B Analyt Technol Biomed Life Sci 877, no. 5–6 (February 15, 2009): 553–57. https://doi.org/10.1016/j.jchromb.2008.12.067.Full Text Link to Item
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Katadae, Maiko, Ken’ichi Hagiwara, Akimori Wada, Masayoshi Ito, Masato Umeda, Patrick J. Casey, and Yoshitaka Fukada. “Interacting targets of the farnesyl of transducin gamma-subunit.” Biochemistry 47, no. 32 (August 12, 2008): 8424–33. https://doi.org/10.1021/bi800359h.Full Text Link to Item
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Wang, Mei, Wanloo Tan, Jin Zhou, Jolene Leow, Meilin Go, How Sung Lee, and Patrick J. Casey. “A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.” J Biol Chem 283, no. 27 (July 4, 2008): 18678–84. https://doi.org/10.1074/jbc.M801855200.Full Text Link to Item
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Rao, P Vasantha, Yuri K. Peterson, Toshihiro Inoue, and Patrick J. Casey. “Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.” Invest Ophthalmol Vis Sci 49, no. 6 (June 2008): 2464–71. https://doi.org/10.1167/iovs.07-1639.Full Text Link to Item
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Kimple, Michelle E., Jamie W. Joseph, Candice L. Bailey, Patrick T. Fueger, Ian A. Hendry, Christopher B. Newgard, and Patrick J. Casey. “Galphaz negatively regulates insulin secretion and glucose clearance.” J Biol Chem 283, no. 8 (February 22, 2008): 4560–67. https://doi.org/10.1074/jbc.M706481200.Full Text Link to Item
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Williams, R Sanders, Patrick J. Casey, Robert K. Kamei, Edward G. Buckley, Khee Chee Soo, Michael H. Merson, Ranga K. Krishnan, and Victor J. Dzau. “A global partnership in medical education between Duke University and the National University of Singapore.” Acad Med 83, no. 2 (February 2008): 122–27. https://doi.org/10.1097/ACM.0b013e318160b8bc.Full Text Link to Item
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Bahmanyar, Shirin, Daniel D. Kaplan, Jennifer G. Deluca, Thomas H. Giddings, Eileen T. O’Toole, Mark Winey, Edward D. Salmon, Patrick J. Casey, W James Nelson, and Angela I. M. Barth. “beta-Catenin is a Nek2 substrate involved in centrosome separation.” Genes Dev 22, no. 1 (January 1, 2008): 91–105. https://doi.org/10.1101/gad.1596308.Full Text Link to Item
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Kelly, Patrick, Patrick J. Casey, and Thomas E. Meigs. “Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.” Biochemistry 46, no. 23 (June 12, 2007): 6677–87. https://doi.org/10.1021/bi700235f.Full Text Link to Item
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Sjogren, Anna-Karin M., Karin M. E. Andersson, Meng Liu, Briony A. Cutts, Christin Karlsson, Annika M. Wahlstrom, Martin Dalin, et al. “GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.” J Clin Invest 117, no. 5 (May 2007): 1294–1304. https://doi.org/10.1172/JCI30868.Full Text Link to Item
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Leow, Jo-Lene, Rudi Baron, Patrick J. Casey, and Mei-Lin Go. “Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.” Bioorg Med Chem Lett 17, no. 4 (February 15, 2007): 1025–32. https://doi.org/10.1016/j.bmcl.2006.11.030.Full Text Link to Item
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Baron, Rudi A., Yuri K. Peterson, James C. Otto, Johannes Rudolph, and Patrick J. Casey. “Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules.” Biochemistry 46, no. 2 (January 16, 2007): 554–60. https://doi.org/10.1021/bi060344n.Full Text Link to Item
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Stemmle, Laura N., Timothy A. Fields, and Patrick J. Casey. “The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.” Mol Pharmacol 70, no. 4 (October 2006): 1461–68. https://doi.org/10.1124/mol.106.023705.Full Text Link to Item
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Kelly, Patrick, Laura N. Stemmle, John F. Madden, Timothy A. Fields, Yehia Daaka, and Patrick J. Casey. “A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.” J Biol Chem 281, no. 36 (September 8, 2006): 26483–90. https://doi.org/10.1074/jbc.M604376200.Full Text Link to Item
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Terry, Kimberly L., Patrick J. Casey, and Lorena S. Beese. “Conversion of protein farnesyltransferase to a geranylgeranyltransferase.” Biochemistry 45, no. 32 (August 15, 2006): 9746–55. https://doi.org/10.1021/bi060295e.Full Text Link to Item
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Kelly, Patrick, Benjamin J. Moeller, Juhi Juneja, Michelle A. Booden, Channing J. Der, Yehia Daaka, Mark W. Dewhirst, Timothy A. Fields, and Patrick J. Casey. “The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.” Proc Natl Acad Sci U S A 103, no. 21 (May 23, 2006): 8173–78. https://doi.org/10.1073/pnas.0510254103.Full Text Link to Item
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Peterson, Yuri K., Patrick Kelly, Carolyn A. Weinbaum, and Patrick J. Casey. “A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.” J Biol Chem 281, no. 18 (May 5, 2006): 12445–50. https://doi.org/10.1074/jbc.M600168200.Full Text Link to Item
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Wang, M., and P. J. Casey. “Isoprenylcysteine carboxylmethyltransferase as a target for development of novel cancer therapeutics.” Drugs of the Future 31, no. 5 (May 1, 2006): 437–45. https://doi.org/10.1358/dof.2006.031.05.994707.Full Text
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Svensson, Annika W., Patrick J. Casey, Stephen G. Young, and Martin O. Bergo. “Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.” Methods Enzymol 407 (2006): 144–59. https://doi.org/10.1016/S0076-6879(05)07013-8.Full Text Link to Item
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Kimple, Michelle E., Andrew B. Nixon, Patrick Kelly, Candice L. Bailey, Kenneth H. Young, Timothy A. Fields, and Patrick J. Casey. “A role for G(z) in pancreatic islet beta-cell biology.” J Biol Chem 280, no. 36 (September 9, 2005): 31708–13. https://doi.org/10.1074/jbc.M506700200.Full Text Link to Item
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Pagliarini, David J., Sandra E. Wiley, Michelle E. Kimple, Jesse R. Dixon, Patrick Kelly, Carolyn A. Worby, Patrick J. Casey, and Jack E. Dixon. “Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.” Mol Cell 19, no. 2 (July 22, 2005): 197–207. https://doi.org/10.1016/j.molcel.2005.06.008.Full Text Link to Item
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Meigs, Thomas E., Juhi Juneja, C Todd DeMarco, Laura N. Stemmle, Daniel D. Kaplan, and Patrick J. Casey. “Selective uncoupling of G alpha 12 from Rho-mediated signaling.” J Biol Chem 280, no. 18 (May 6, 2005): 18049–55. https://doi.org/10.1074/jbc.M500445200.Full Text Link to Item
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Winter-Vann, Ann M., and Patrick J. Casey. “Post-prenylation-processing enzymes as new targets in oncogenesis.” Nat Rev Cancer 5, no. 5 (May 2005): 405–12. https://doi.org/10.1038/nrc1612.Full Text Link to Item
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Mijimolle, Nieves, Juan Velasco, Pierre Dubus, Carmen Guerra, Carolyn A. Weinbaum, Patrick J. Casey, Victoria Campuzano, and Mariano Barbacid. “Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.” Cancer Cell 7, no. 4 (April 2005): 313–24. https://doi.org/10.1016/j.ccr.2005.03.004.Full Text Link to Item
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Wittchen, Erika S., Rebecca A. Worthylake, Patrick Kelly, Patrick J. Casey, Lawrence A. Quilliam, and Keith Burridge. “Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.” J Biol Chem 280, no. 12 (March 25, 2005): 11675–82. https://doi.org/10.1074/jbc.M412595200.Full Text Link to Item
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Kasbohm, Elizabeth A., Rishu Guo, Charles W. Yowell, Gargi Bagchi, Patrick Kelly, Puneeta Arora, Patrick J. Casey, and Yehia Daaka. “Androgen receptor activation by G(s) signaling in prostate cancer cells.” J Biol Chem 280, no. 12 (March 25, 2005): 11583–89. https://doi.org/10.1074/jbc.M414423200.Full Text Link to Item
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Winter-Vann, Ann M., Rudi A. Baron, Waihay Wong, June dela Cruz, John D. York, David M. Gooden, Martin O. Bergo, Stephen G. Young, Eric J. Toone, and Patrick J. Casey. “A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.” Proc Natl Acad Sci U S A 102, no. 12 (March 22, 2005): 4336–41. https://doi.org/10.1073/pnas.0408107102.Full Text Link to Item
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Clancy, Sinead M., Catherine E. Fowler, Melissa Finley, Ka Fai Suen, Christine Arrabit, Frédérique Berton, Tohru Kosaza, Patrick J. Casey, and Paul A. Slesinger. “Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.” Mol Cell Neurosci 28, no. 2 (February 2005): 375–89. https://doi.org/10.1016/j.mcn.2004.10.009.Full Text Link to Item
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Baron, Rudi A., and Patrick J. Casey. “Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt).” Bmc Biochem 5 (December 29, 2004): 19. https://doi.org/10.1186/1471-2091-5-19.Full Text Link to Item
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Embry, Alan C., Jennifer L. Glick, Maurine E. Linder, and Patrick J. Casey. “Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.” Mol Pharmacol 66, no. 5 (November 2004): 1325–31. https://doi.org/10.1124/mol.104.004093.Full Text Link to Item
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Reid, T Scott, Kimberly L. Terry, Patrick J. Casey, and Lorena S. Beese. “Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.” J Mol Biol 343, no. 2 (October 15, 2004): 417–33. https://doi.org/10.1016/j.jmb.2004.08.056.Full Text Link to Item
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Kaplan, Daniel D., Thomas E. Meigs, Patrick Kelly, and Patrick J. Casey. “Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle.” J Biol Chem 279, no. 12 (March 19, 2004): 10829–32. https://doi.org/10.1074/jbc.C400035200.Full Text Link to Item
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Bergo, Martin O., Hsiao D. Lieu, Bryant J. Gavino, Patricia Ambroziak, James C. Otto, Patrick J. Casey, Quinn M. Walker, and Stephen G. Young. “On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.” J Biol Chem 279, no. 6 (February 6, 2004): 4729–36. https://doi.org/10.1074/jbc.M310081200.Full Text Link to Item
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Bergo, Martin O., Bryant J. Gavino, Christine Hong, Anne P. Beigneux, Martin McMahon, Patrick J. Casey, and Stephen G. Young. “Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.” J Clin Invest 113, no. 4 (February 2004): 539–50. https://doi.org/10.1172/JCI18829.Full Text Link to Item
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Hagiwara, Ken’ichi, Akimori Wada, Maiko Katadae, Masayoshi Ito, Yoshikazu Ohya, Patrick J. Casey, and Yoshitaka Fukada. “Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.” Biochemistry 43, no. 2 (January 20, 2004): 300–309. https://doi.org/10.1021/bi0351514.Full Text Link to Item
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Nixon, Andrew B., and Patrick J. Casey. “Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.” Methods Enzymol 390 (2004): 53–64. https://doi.org/10.1016/S0076-6879(04)90004-3.Full Text Link to Item
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Park, Jewn Giew, Kevin J. Langenwalter, Carolyn A. Weinbaum, Patrick J. Casey, and Yuan-Ping Pang. “Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors.” J Comb Chem 6, no. 3 (2004): 407–13. https://doi.org/10.1021/cc0340729.Full Text Link to Item
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Taylor, Jeffrey S., T Scott Reid, Kimberly L. Terry, Patrick J. Casey, and Lorena S. Beese. “Structure of mammalian protein geranylgeranyltransferase type-I.” Embo J 22, no. 22 (November 17, 2003): 5963–74. https://doi.org/10.1093/emboj/cdg571.Full Text Link to Item
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Fiordalisi, James J., Ronald L. Johnson, Carolyn A. Weinbaum, Kaoru Sakabe, Zhui Chen, Patrick J. Casey, and Adrienne D. Cox. “High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.” J Biol Chem 278, no. 43 (October 24, 2003): 41718–27. https://doi.org/10.1074/jbc.M305733200.Full Text Link to Item
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Pickett, Jennifer S., Katherine E. Bowers, Heather L. Hartman, Hua-Wen Fu, Alan C. Embry, Patrick J. Casey, and Carol A. Fierke. “Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.” Biochemistry 42, no. 32 (August 19, 2003): 9741–48. https://doi.org/10.1021/bi0346852.Full Text Link to Item
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Winter-Vann, Ann M., Barton A. Kamen, Martin O. Bergo, Stephen G. Young, Stepan Melnyk, S Jill James, and Patrick J. Casey. “Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.” Proc Natl Acad Sci U S A 100, no. 11 (May 27, 2003): 6529–34. https://doi.org/10.1073/pnas.1135239100.Full Text Link to Item
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Gilman, Alfred G., Melvin I. Simon, Henry R. Bourne, Bruce A. Harris, Rochelle Long, Elliott M. Ross, James T. Stull, et al. “Overview of the Alliance for Cellular Signaling.” Nature 420, no. 6916 (December 12, 2002): 703–6. https://doi.org/10.1038/nature01304.Full Text Link to Item
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Meng, Jingwei, and Patrick J. Casey. “Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.” J Biol Chem 277, no. 45 (November 8, 2002): 43417–24. https://doi.org/10.1074/jbc.M204074200.Full Text Link to Item
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Digits, Jennifer A., Hyung-Jung Pyun, Robert M. Coates, and Patrick J. Casey. “Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.” J Biol Chem 277, no. 43 (October 25, 2002): 41086–93. https://doi.org/10.1074/jbc.M208069200.Full Text Link to Item
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Beigneux, Anne, Shannon K. Withycombe, Jennifer A. Digits, William R. Tschantz, Carolyn A. Weinbaum, Stephen M. Griffey, Martin Bergo, Patrick J. Casey, and Stephen G. Young. “Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.” J Biol Chem 277, no. 41 (October 11, 2002): 38358–63. https://doi.org/10.1074/jbc.M205183200.Full Text Link to Item
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Long, Stephen B., Patrick J. Casey, and Lorena S. Beese. “Reaction path of protein farnesyltransferase at atomic resolution.” Nature 419, no. 6907 (October 10, 2002): 645–50. https://doi.org/10.1038/nature00986.Full Text Link to Item
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Meigs, Thomas E., Mary Fedor-Chaiken, Daniel D. Kaplan, Robert Brackenbury, and Patrick J. Casey. “Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.” J Biol Chem 277, no. 27 (July 5, 2002): 24594–600. https://doi.org/10.1074/jbc.M201984200.Full Text Link to Item
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Nixon, Andrew B., Gabriele Grenningloh, and Patrick J. Casey. “The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.” J Biol Chem 277, no. 20 (May 17, 2002): 18127–33. https://doi.org/10.1074/jbc.M201065200.Full Text Link to Item
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Bergo, Martin O., Patricia Ambroziak, Cria Gregory, Amanda George, James C. Otto, Edward Kim, Hiroki Nagase, Patrick J. Casey, Allan Balmain, and Stephen G. Young. “Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.” Mol Cell Biol 22, no. 1 (January 2002): 171–81. https://doi.org/10.1128/MCB.22.1.171-181.2002.Full Text Link to Item
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Hurwitz, H. I., and P. J. Casey. “Prenylation of CaaX-type proteins: Basic principles through clinical applications.” Current Topics in Membranes 52 (January 1, 2002): 531–50. https://doi.org/10.1016/s1063-5823(02)52021-4.Full Text
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Hightower, K. E., S. De, C. Weinbaum, R. A. Spence, and P. J. Casey. “Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.” Biochem J 360, no. Pt 3 (December 15, 2001): 625–31. https://doi.org/10.1042/0264-6021:3600625.Full Text Link to Item
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Spence, R. A., and P. J. Casey. “1 Mechanism of catalysis by protein farnesyltransferase.” Enzymes 21, no. C (December 1, 2001): 1–18. https://doi.org/10.1016/S1874-6047(01)80014-7.Full Text
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Kaplan, D. D., T. E. Meigs, and P. J. Casey. “Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin.” J Biol Chem 276, no. 47 (November 23, 2001): 44037–43. https://doi.org/10.1074/jbc.M106121200.Full Text Link to Item
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Burgon, P. G., W. L. Lee, A. B. Nixon, E. G. Peralta, and P. J. Casey. “Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).” J Biol Chem 276, no. 35 (August 31, 2001): 32828–34. https://doi.org/10.1074/jbc.M100960200.Full Text Link to Item
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Bergo, M. O., G. K. Leung, P. Ambroziak, J. C. Otto, P. J. Casey, A. Q. Gomes, M. C. Seabra, and S. G. Young. “Isoprenylcysteine carboxyl methyltransferase deficiency in mice.” J Biol Chem 276, no. 8 (February 23, 2001): 5841–45. https://doi.org/10.1074/jbc.C000831200.Full Text Link to Item
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Schlitzer, M., A. Winter-Vann, and P. J. Casey. “Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.” Bioorg Med Chem Lett 11, no. 3 (February 12, 2001): 425–27. https://doi.org/10.1016/s0960-894x(00)00685-5.Full Text Link to Item
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Hightower, K. E., P. J. Casey, and C. A. Fierke. “Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.” Biochemistry 40, no. 4 (January 30, 2001): 1002–10. https://doi.org/10.1021/bi002237d.Full Text Link to Item
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Tschantz, W. R., J. A. Digits, H. J. Pyun, R. M. Coates, and P. J. Casey. “Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.” J Biol Chem 276, no. 4 (January 26, 2001): 2321–24. https://doi.org/10.1074/jbc.C000616200.Full Text Link to Item
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Meigs, T. E., T. A. Fields, D. D. McKee, and P. J. Casey. “Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.” Proc Natl Acad Sci U S A 98, no. 2 (January 16, 2001): 519–24. https://doi.org/10.1073/pnas.98.2.519.Full Text Link to Item
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Chen, Z., J. C. Otto, M. O. Bergo, S. G. Young, and P. J. Casey. “The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules.” J Biol Chem 275, no. 52 (December 29, 2000): 41251–57. https://doi.org/10.1074/jbc.M006687200.Full Text Link to Item
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Spence, R. A., K. E. Hightower, K. L. Terry, L. S. Beese, C. A. Fierke, and P. J. Casey. “Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.” Biochemistry 39, no. 45 (November 14, 2000): 13651–59. https://doi.org/10.1021/bi001084r.Full Text Link to Item
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Bergo, M. O., G. K. Leung, P. Ambroziak, J. C. Otto, P. J. Casey, and S. G. Young. “Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.” J Biol Chem 275, no. 23 (June 9, 2000): 17605–10. https://doi.org/10.1074/jbc.C000079200.Full Text Link to Item
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Long, S. B., P. J. Casey, and L. S. Beese. “The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.” Structure 8, no. 2 (February 15, 2000): 209–22. https://doi.org/10.1016/s0969-2126(00)00096-4.Full Text Link to Item
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Meng, J., J. L. Glick, P. Polakis, and P. J. Casey. “Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk.” J Biol Chem 274, no. 51 (December 17, 1999): 36663–69. https://doi.org/10.1074/jbc.274.51.36663.Full Text Link to Item
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Tschantz, W. R., L. Zhang, and P. J. Casey. “Cloning, expression, and cellular localization of a human prenylcysteine lyase.” J Biol Chem 274, no. 50 (December 10, 1999): 35802–8. https://doi.org/10.1074/jbc.274.50.35802.Full Text Link to Item
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Kim, E., P. Ambroziak, J. C. Otto, B. Taylor, M. Ashby, K. Shannon, P. J. Casey, and S. G. Young. “Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.” J Biol Chem 274, no. 13 (March 26, 1999): 8383–90. https://doi.org/10.1074/jbc.274.13.8383.Full Text Link to Item
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Otto, J. C., E. Kim, S. G. Young, and P. J. Casey. “Cloning and characterization of a mammalian prenyl protein-specific protease.” J Biol Chem 274, no. 13 (March 26, 1999): 8379–82. https://doi.org/10.1074/jbc.274.13.8379.Full Text Link to Item
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Fu, H. W., and P. J. Casey. “Enzymology and biology of CaaX protein prenylation.” Recent Prog Horm Res 54 (1999): 315–42.Link to Item
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Hightower, K. E., C. C. Huang, P. J. Casey, and C. A. Fierke. “H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.” Biochemistry 37, no. 44 (November 3, 1998): 15555–62. https://doi.org/10.1021/bi981525v.Full Text Link to Item
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Glick, J. L., T. E. Meigs, A. Miron, and P. J. Casey. “RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.” J Biol Chem 273, no. 40 (October 2, 1998): 26008–13. https://doi.org/10.1074/jbc.273.40.26008.Full Text Link to Item
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Long, S. B., P. J. Casey, and L. S. Beese. “Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.” Biochemistry 37, no. 27 (July 7, 1998): 9612–18. https://doi.org/10.1021/bi980708e.Full Text Link to Item
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Fu, H. W., L. S. Beese, and P. J. Casey. “Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.” Biochemistry 37, no. 13 (March 31, 1998): 4465–72. https://doi.org/10.1021/bi972511c.Full Text Link to Item
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Fu, H. W., and P. J. Casey. “Structure-function analysis of residues important in zinc binding and activity in protein farnes yltransferase.” Faseb Journal 11, no. 9 (December 1, 1997).
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Huang, C. C., P. J. Casey, and C. A. Fierke. “Functions of metals in protein farnesyltransferase.” Faseb Journal 11, no. 9 (December 1, 1997).
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Otto, J. C., and P. J. Casey. “Analysis of the C-terminal proteolysis of prenylated proteins.” Faseb Journal 11, no. 9 (December 1, 1997).
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Tschantz, W. R., E. S. Furfine, and P. J. Casey. “Substrate binding is required for release of product from mammalian protein farnesyltransferase.” Faseb Journal 11, no. 9 (December 1, 1997).
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Thissen, J. A., J. M. Gross, K. Subramanian, T. Meyer, and P. J. Casey. “Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.” J Biol Chem 272, no. 48 (November 28, 1997): 30362–70. https://doi.org/10.1074/jbc.272.48.30362.Full Text Link to Item
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Hurwitz, L. M., and P. J. Casey. “Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?” Chem Biol 4, no. 10 (October 1997): 711–15. https://doi.org/10.1016/s1074-5521(97)90308-2.Full Text Link to Item
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Zhang, L., W. R. Tschantz, and P. J. Casey. “Isolation and characterization of a prenylcysteine lyase from bovine brain.” J Biol Chem 272, no. 37 (September 12, 1997): 23354–59. https://doi.org/10.1074/jbc.272.37.23354.Full Text Link to Item
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Lebowitz, P. F., P. J. Casey, G. C. Prendergast, and J. A. Thissen. “Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB.” J Biol Chem 272, no. 25 (June 20, 1997): 15591–94. https://doi.org/10.1074/jbc.272.25.15591.Full Text Link to Item
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Tschantz, W. R., E. S. Furfine, and P. J. Casey. “Substrate binding is required for release of product from mammalian protein farnesyltransferase.” J Biol Chem 272, no. 15 (April 11, 1997): 9989–93. https://doi.org/10.1074/jbc.272.15.9989.Full Text Link to Item
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Park, H. W., S. R. Boduluri, J. F. Moomaw, P. J. Casey, and L. S. Beese. “Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.” Science 275, no. 5307 (March 21, 1997): 1800–1804. https://doi.org/10.1126/science.275.5307.1800.Full Text Link to Item
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Fields, T. A., and P. J. Casey. “Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.” Biochem J 321 ( Pt 3), no. Pt 3 (February 1, 1997): 561–71. https://doi.org/10.1042/bj3210561.Full Text Link to Item
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Huang, C. C., P. J. Casey, and C. A. Fierke. “Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate.” J Biol Chem 272, no. 1 (January 3, 1997): 20–23. https://doi.org/10.1074/jbc.272.1.20.Full Text Link to Item
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Huang, C. C., P. J. Casey, and C. A. Fierke. “Functions of metals in protein farnesyltransferase.” Faseb Journal 11, no. 9 (1997): A1307.
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Otto, J. C., and P. J. Casey. “Analysis of the C-terminal proteolysis of prenylated proteins.” Faseb Journal 11, no. 9 (1997): A1087.
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Tschantz, W. R., E. S. Furfine, and P. J. Casey. “Substrate binding is required for release of product from mammalian protein farnesyltransferase.” Faseb Journal 11, no. 9 (1997): A1086.
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Zhang, F. L., and P. J. Casey. “Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.” Biochem J 320 ( Pt 3), no. Pt 3 (December 15, 1996): 925–32. https://doi.org/10.1042/bj3200925.Full Text Link to Item
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Higgins, J. B., and P. J. Casey. “[8] Assays for G protein βγ subunit activity.” Methods in Neurosciences 29, no. C (December 1, 1996): 90–100. https://doi.org/10.1016/S1043-9471(96)80044-9.Full Text
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Otto, J. C., K. N. Hayward, and P. J. Casey. “Prenylation of the hepatitis delta virus large antigen: a new target for farnesyltransferase inhibitors.” Faseb Journal 10, no. 6 (December 1, 1996).
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Thissen, J. A., and P. J. Casey. “Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions.” Anal Biochem 243, no. 1 (December 1, 1996): 80–85. https://doi.org/10.1006/abio.1996.0484.Full Text Link to Item
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Fu, H. W., J. F. Moomaw, C. R. Moomaw, and P. J. Casey. “Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme.” J Biol Chem 271, no. 45 (November 8, 1996): 28541–48. https://doi.org/10.1074/jbc.271.45.28541.Full Text Link to Item
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Hunt, T. W., T. A. Fields, P. J. Casey, and E. G. Peralta. “RGS10 is a selective activator of G alpha i GTPase activity.” Nature 383, no. 6596 (September 12, 1996): 175–77. https://doi.org/10.1038/383175a0.Full Text Link to Item
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Higgins, J. B., and P. J. Casey. “The role of prenylation in G-protein assembly and function.” Cell Signal 8, no. 6 (September 1996): 433–37. https://doi.org/10.1016/s0898-6568(96)00071-x.Full Text Link to Item
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Zhang, F. L., H. W. Fu, P. J. Casey, and W. R. Bishop. “Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.” Biochemistry 35, no. 25 (June 25, 1996): 8166–71. https://doi.org/10.1021/bi960574+.Full Text Link to Item
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Casey, P. J., and M. C. Seabra. “Protein prenyltransferases.” J Biol Chem 271, no. 10 (March 8, 1996): 5289–92. https://doi.org/10.1074/jbc.271.10.5289.Full Text Link to Item
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Otto, J. C., and P. J. Casey. “The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells.” J Biol Chem 271, no. 9 (March 1, 1996): 4569–72. https://doi.org/10.1074/jbc.271.9.4569.Full Text Link to Item
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Glick, J., G. Santoyo, and P. J. Casey. “Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz.” J Biol Chem 271, no. 6 (February 9, 1996): 2949–54. https://doi.org/10.1074/jbc.271.6.2949.Full Text Link to Item
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Otto, J. Ç., K. N. Hayward, and P. J. Casey. “Prenylation of the hepatitis delta virus large antigen: a new target for farnesyltransferase inhibitors.” Faseb Journal 10, no. 6 (1996): A1501.
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Zhang, F. L., and P. J. Casey. “Protein prenylation: molecular mechanisms and functional consequences.” Annu Rev Biochem 65 (1996): 241–69. https://doi.org/10.1146/annurev.bi.65.070196.001325.Full Text Link to Item
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Huang, C. L., P. A. Slesinger, P. J. Casey, Y. N. Jan, and L. Y. Jan. “Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.” Neuron 15, no. 5 (November 1995): 1133–43. https://doi.org/10.1016/0896-6273(95)90101-9.Full Text Link to Item
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Fields, T. A., and P. J. Casey. “Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.” J Biol Chem 270, no. 39 (September 29, 1995): 23119–25. https://doi.org/10.1074/jbc.270.39.23119.Full Text Link to Item
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Zhang, L., C. W. Sachs, H. W. Fu, R. L. Fine, and P. J. Casey. “Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells.” J Biol Chem 270, no. 39 (September 29, 1995): 22859–65. https://doi.org/10.1074/jbc.270.39.22859.Full Text Link to Item
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Furfine, E. S., J. J. Leban, A. Landavazo, J. F. Moomaw, and P. J. Casey. “Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.” Biochemistry 34, no. 20 (May 23, 1995): 6857–62. https://doi.org/10.1021/bi00020a032.Full Text Link to Item
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Casey, P. J. “Protein lipidation in cell signaling.” Science 268, no. 5208 (April 14, 1995): 221–25. https://doi.org/10.1126/science.7716512.Full Text Link to Item
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Casey, P. J. “Mechanisms of protein prenylation and role in G protein function.” Biochem Soc Trans 23, no. 1 (February 1995): 161–66. https://doi.org/10.1042/bst0230161.Full Text Link to Item
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Casey, P. J., and J. E. Buss. “Lipid modifications of protein: Preface.” Methods in Enzymology 250 (January 1, 1995). https://doi.org/10.1016/0076-6879(95)50055-3.Full Text
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Moomaw, J. F., F. L. Zhang, and P. J. Casey. “Isolation of protein prenyltransferases from bovine brain and baculovirus expression system.” Methods Enzymol 250 (1995): 12–21. https://doi.org/10.1016/0076-6879(95)50058-8.Full Text Link to Item
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Thissen, J. A., M. G. Barrett, and P. J. Casey. “Prenylated peptides in identification of specific binding proteins.” Methods Enzymol 250 (1995): 158–68. https://doi.org/10.1016/0076-6879(95)50070-7.Full Text Link to Item
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Zhang, F. L., J. F. Moomaw, and P. J. Casey. “Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.” J Biol Chem 269, no. 38 (September 23, 1994): 23465–70.Link to Item
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Thomason, P. A., S. R. James, P. J. Casey, and C. P. Downes. “A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.” J Biol Chem 269, no. 24 (June 17, 1994): 16525–28.Link to Item
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Zhang, L., C. W. Sachs, R. L. Fine, and P. J. Casey. “Interaction of prenylcysteine methyl esters with the multidrug resistance transporter.” J Biol Chem 269, no. 23 (June 10, 1994): 15973–76.Link to Item
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Fields, T. A., M. E. Linder, and P. J. Casey. “Subtype-specific binding of azidoanilido-GTP by purified G protein alpha subunits.” Biochemistry 33, no. 22 (June 7, 1994): 6877–83. https://doi.org/10.1021/bi00188a017.Full Text Link to Item
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Casey, P. J. “Lipid modifications of G proteins.” Curr Opin Cell Biol 6, no. 2 (April 1994): 219–25. https://doi.org/10.1016/0955-0674(94)90139-2.Full Text Link to Item
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Higgins, J. B., and P. J. Casey. “In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.” J Biol Chem 269, no. 12 (March 25, 1994): 9067–73.Link to Item
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Zhang, F. L., R. E. Diehl, N. E. Kohl, J. B. Gibbs, B. Giros, P. J. Casey, and C. A. Omer. “cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.” J Biol Chem 269, no. 5 (February 4, 1994): 3175–80.Link to Item
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Casey, P. J., J. F. Moomaw, F. L. Zhang, Y. B. Higgins, and J. A. Thissen. “Prenylation and G protein signaling.” Recent Prog Horm Res 49 (1994): 215–38. https://doi.org/10.1016/b978-0-12-571149-4.50015-5.Full Text Link to Item
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Thissen, J. A., and P. J. Casey. “Microsomal membranes contain a high affinity binding site for prenylated peptides.” J Biol Chem 268, no. 19 (July 5, 1993): 13780–83.Link to Item
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Chen, W. J., J. F. Moomaw, L. Overton, T. A. Kost, and P. J. Casey. “High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc.” J Biol Chem 268, no. 13 (May 5, 1993): 9675–80.Link to Item
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Casey, P. J. “Biochemistry of protein prenylation.” J Lipid Res 33, no. 12 (December 1992): 1731–40.Link to Item
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Casey, P. “G proteins. Visual differences.” Nature 359, no. 6397 (October 22, 1992): 671–72. https://doi.org/10.1038/359671a0.Full Text Link to Item
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Caplan, A. J., J. Tsai, P. J. Casey, and M. G. Douglas. “Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.” J Biol Chem 267, no. 26 (September 15, 1992): 18890–95.Link to Item
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Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. “Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.” Science 257, no. 5074 (August 28, 1992): 1264–67. https://doi.org/10.1126/science.1325672.Full Text Link to Item
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Moomaw, J. F., and P. J. Casey. “Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.” J Biol Chem 267, no. 24 (August 25, 1992): 17438–43.Link to Item
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Ménard, L., E. Tomhave, P. J. Casey, R. J. Uhing, R. Snyderman, and J. R. Didsbury. “Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.” Eur J Biochem 206, no. 2 (June 1, 1992): 537–46. https://doi.org/10.1111/j.1432-1033.1992.tb16957.x.Full Text Link to Item
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Colombo, M. I., L. S. Mayorga, P. J. Casey, and P. D. Stahl. “Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion.” Science 255, no. 5052 (March 27, 1992): 1695–97. https://doi.org/10.1126/science.1348148.Full Text Link to Item
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Lounsbury, K. M., P. J. Casey, L. F. Brass, and D. R. Manning. “Phosphorylation of Gz in human platelets. Selectivity and site of modification.” J Biol Chem 266, no. 32 (November 15, 1991): 22051–56.Link to Item
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Casey, P. J., J. A. Thissen, and J. F. Moomaw. “Enzymatic modification of proteins with a geranylgeranyl isoprenoid.” Proc Natl Acad Sci U S A 88, no. 19 (October 1, 1991): 8631–35. https://doi.org/10.1073/pnas.88.19.8631.Full Text Link to Item
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Seabra, M. C., Y. Reiss, P. J. Casey, M. S. Brown, and J. L. Goldstein. “Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.” Cell 65, no. 3 (May 3, 1991): 429–34. https://doi.org/10.1016/0092-8674(91)90460-g.Full Text Link to Item
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Buss, J. E., L. A. Quilliam, K. Kato, P. J. Casey, P. A. Solski, G. Wong, R. Clark, F. McCormick, G. M. Bokoch, and C. J. Der. “The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.” Mol Cell Biol 11, no. 3 (March 1991): 1523–30. https://doi.org/10.1128/mcb.11.3.1523-1530.1991.Full Text Link to Item
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Casey, P. J., I. H. Pang, and A. G. Gilman. “Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha.” Methods Enzymol 195 (1991): 315–21. https://doi.org/10.1016/0076-6879(91)95176-k.Full Text Link to Item
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Mumby, S. M., P. J. Casey, A. G. Gilman, S. Gutowski, and P. C. Sternweis. “G protein gamma subunits contain a 20-carbon isoprenoid.” Proc Natl Acad Sci U S A 87, no. 15 (August 1990): 5873–77. https://doi.org/10.1073/pnas.87.15.5873.Full Text Link to Item
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Hinton, D. R., J. C. Blanks, H. K. Fong, P. J. Casey, E. Hildebrandt, and M. I. Simons. “Novel localization of a G protein, Gz-alpha, in neurons of brain and retina.” J Neurosci 10, no. 8 (August 1990): 2763–70. https://doi.org/10.1523/JNEUROSCI.10-08-02763.1990.Full Text Link to Item
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Reiss, Y., J. L. Goldstein, M. C. Seabra, P. J. Casey, and M. S. Brown. “Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.” Cell 62, no. 1 (July 13, 1990): 81–88. https://doi.org/10.1016/0092-8674(90)90242-7.Full Text Link to Item
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Casey, P. J., H. K. Fong, M. I. Simon, and A. G. Gilman. “Gz, a guanine nucleotide-binding protein with unique biochemical properties.” J Biol Chem 265, no. 4 (February 5, 1990): 2383–90.Link to Item
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Farnsworth, C. C., P. J. Casey, W. N. Howald, J. A. Glomset, and M. H. Gelb. “Structural characterization of prenyl groups attached to proteins.” Methods 1, no. 3 (January 1, 1990): 231–40. https://doi.org/10.1016/S1046-2023(05)80322-6.Full Text
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Casey, P. J., P. A. Solski, C. J. Der, and J. E. Buss. “p21ras is modified by a farnesyl isoprenoid.” Proc Natl Acad Sci U S A 86, no. 21 (November 1989): 8323–27. https://doi.org/10.1073/pnas.86.21.8323.Full Text Link to Item
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Freissmuth, M., P. J. Casey, and A. G. Gilman. “G proteins control diverse pathways of transmembrane signaling.” Faseb J 3, no. 10 (August 1989): 2125–31.Link to Item
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Casey, P. J., M. P. Graziano, and A. G. Gilman. “G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.” Biochemistry 28, no. 2 (January 24, 1989): 611–16. https://doi.org/10.1021/bi00428a029.Full Text Link to Item
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Casey, P. J., and A. G. Gilman. “G protein involvement in receptor-effector coupling.” J Biol Chem 263, no. 6 (February 25, 1988): 2577–80.Link to Item
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Casey, P. J., M. P. Graziano, M. Friessmuth, and A. G. Gilman. “Role of G proteins in transmembrane signaling.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 1 (1988): 203–8.
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Buss, J. E., S. M. Mumby, P. J. Casey, A. G. Gilman, and B. M. Sefton. “Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.” Proc Natl Acad Sci U S A 84, no. 21 (November 1987): 7493–97. https://doi.org/10.1073/pnas.84.21.7493.Full Text Link to Item
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Casey, P. J., and J. M. Lowenstein. “Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate.” Biochem J 246, no. 2 (September 1, 1987): 263–69. https://doi.org/10.1042/bj2460263.Full Text Link to Item
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Graziano, M. P., P. J. Casey, and A. G. Gilman. “Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.” J Biol Chem 262, no. 23 (August 15, 1987): 11375–81.Link to Item
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Casey, P. J., and J. M. Lowenstein. “Inhibition of adenylosuccinate lyase by L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (alanosyl-AICOR).” Biochem Pharmacol 36, no. 5 (March 1, 1987): 705–9. https://doi.org/10.1016/0006-2952(87)90722-2.Full Text Link to Item
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Casey, P. J., R. H. Abeles, and J. M. Lowenstein. “Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates.” J Biol Chem 261, no. 29 (October 15, 1986): 13637–42.Link to Item
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Casey, P. J., and J. M. Lowenstein. “Purification and characterization of adenylosuccinate lyase from rat skeletal muscle.” Federation Proceedings 44, no. 5 (January 1, 1985).
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Book Sections
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Kimple, M. E., R. C. Hultman, and P. J. Casey. “Signaling Through Gz.” In Handbook of Cell Signaling, Second Edition, 2:1649–53, 2009. https://doi.org/10.1016/B978-0-12-374145-5.00202-3.Full Text
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Meng, J., and P. J. Casey. “Signaling through Gz.” In Handbook of Cell Signaling: Volume 1-3, 1–3:601–4, 2003. https://doi.org/10.1016/B978-012124546-7/50580-5.Full Text
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Conference Papers
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Casey, P. J., M. P. Graziano, M. Freissmuth, and A. G. Gilman. “Role of G proteins in transmembrane signaling.” In Cold Spring Harb Symp Quant Biol, 53 Pt 1:203–8, 1988. https://doi.org/10.1101/sqb.1988.053.01.026.Full Text Link to Item
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