Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials.
Journal Article (Journal Article)
Some clinical trials follow a design where patients are randomized to a primary therapy at entry followed by another randomization to maintenance therapy contingent upon disease remission. Ideally, analysis would allow different treatment policies, i.e., combinations of primary and maintenance therapy if specified up-front, to be compared. Standard practice is to conduct separate analyses for the primary and follow-up treatments, which does not address this issue directly. We propose consistent estimators for the survival distribution and mean restricted survival time for each treatment policy in such two-stage studies and derive large-sample properties. The methods are demonstrated on a leukemia clinical trial data set and through simulation.
Full Text
Duke Authors
Cited Authors
- Lunceford, JK; Davidian, M; Tsiatis, AA
Published Date
- March 2002
Published In
Volume / Issue
- 58 / 1
Start / End Page
- 48 - 57
PubMed ID
- 11890326
International Standard Serial Number (ISSN)
- 0006-341X
Digital Object Identifier (DOI)
- 10.1111/j.0006-341x.2002.00048.x
Language
- eng
Conference Location
- United States