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Relationship of cardiac chamber volume to baroreflex activity in normal humans.

Publication ,  Journal Article
Nabel, EG; Colucci, WS; Lilly, LS; Cutler, SS; Majzoub, JA; St John Sutton, MG; Dzau, VJ; Creager, MA
Published in: J Clin Endocrinol Metab
September 1987

The objectives of this study were to examine the effect of incremental lower body negative pressure (LBNP) on cardiac chamber volume and assess the relationship between cardiac chamber volume and baroreflex activation of the neurohormonal axis. Accordingly, echocardiographic determination of cardiac chamber volume and neurohormonal responses were studied in 14 normal subjects during incremental LBNP. LBNP -10 mm Hg decreased left atrial diameter and left ventricular systolic volume index, but did not alter heart rate, systolic or pulse pressure, or stroke volume. During LBNP -10 mm Hg, plasma norepinephrine levels increased, suggesting activation of the sympathetic nervous system. LBNP -40 mm Hg caused a significant decrease in left atrial diameter and left ventricular systolic, diastolic, and stroke volume indices. During LBNP -40 mm Hg, heart rate increased, and systolic and pulse pressure fell. With this more negative level of LBNP, norepinephrine, angiotensin II, aldosterone, and arginine vasopressin concentrations and PRA all increased. The findings that left atrial diameter decreased and plasma norepinephrine concentration increased during LBNP -10 mm Hg suggest that the sympathetic nervous system is sensitive to changes in atrial receptor activity. At higher levels of LBNP (-40 mm Hg), activation of the renin-angiotensin system and release of vasopressin were associated with a fall in left ventricular diastolic volume as well as a decrease in the pressure input to the arterial baroreceptors. Under this condition, the differential contribution of the cardiopulmonary and arterial baroreceptors to the regulation of the renin-angiotensin system and vasopressin release cannot be distinguished.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

September 1987

Volume

65

Issue

3

Start / End Page

475 / 481

Location

United States

Related Subject Headings

  • Ventricular Function
  • Renin-Angiotensin System
  • Reflex
  • Pressoreceptors
  • Male
  • Lower Body Negative Pressure
  • Humans
  • Hemodynamics
  • Female
  • Endocrinology & Metabolism
 

Citation

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Nabel, E. G., Colucci, W. S., Lilly, L. S., Cutler, S. S., Majzoub, J. A., St John Sutton, M. G., … Creager, M. A. (1987). Relationship of cardiac chamber volume to baroreflex activity in normal humans. J Clin Endocrinol Metab, 65(3), 475–481. https://doi.org/10.1210/jcem-65-3-475
Nabel, E. G., W. S. Colucci, L. S. Lilly, S. S. Cutler, J. A. Majzoub, M. G. St John Sutton, V. J. Dzau, and M. A. Creager. “Relationship of cardiac chamber volume to baroreflex activity in normal humans.J Clin Endocrinol Metab 65, no. 3 (September 1987): 475–81. https://doi.org/10.1210/jcem-65-3-475.
Nabel EG, Colucci WS, Lilly LS, Cutler SS, Majzoub JA, St John Sutton MG, et al. Relationship of cardiac chamber volume to baroreflex activity in normal humans. J Clin Endocrinol Metab. 1987 Sep;65(3):475–81.
Nabel, E. G., et al. “Relationship of cardiac chamber volume to baroreflex activity in normal humans.J Clin Endocrinol Metab, vol. 65, no. 3, Sept. 1987, pp. 475–81. Pubmed, doi:10.1210/jcem-65-3-475.
Nabel EG, Colucci WS, Lilly LS, Cutler SS, Majzoub JA, St John Sutton MG, Dzau VJ, Creager MA. Relationship of cardiac chamber volume to baroreflex activity in normal humans. J Clin Endocrinol Metab. 1987 Sep;65(3):475–481.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

September 1987

Volume

65

Issue

3

Start / End Page

475 / 481

Location

United States

Related Subject Headings

  • Ventricular Function
  • Renin-Angiotensin System
  • Reflex
  • Pressoreceptors
  • Male
  • Lower Body Negative Pressure
  • Humans
  • Hemodynamics
  • Female
  • Endocrinology & Metabolism