Endoreplication and polyploidy: insights into development and disease.

Journal Article (Journal Article;Review)

Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer.

Full Text

Duke Authors

Cited Authors

  • Fox, DT; Duronio, RJ

Published Date

  • January 1, 2013

Published In

Volume / Issue

  • 140 / 1

Start / End Page

  • 3 - 12

PubMed ID

  • 23222436

Pubmed Central ID

  • PMC3513989

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.080531


  • eng

Conference Location

  • England