Endoreplication and polyploidy: insights into development and disease.
Publication
, Journal Article
Fox, DT; Duronio, RJ
Published in: Development
January 1, 2013
Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer.
Duke Scholars
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Published In
Development
DOI
EISSN
1477-9129
Publication Date
January 1, 2013
Volume
140
Issue
1
Start / End Page
3 / 12
Location
England
Related Subject Headings
- Polyploidy
- Plants
- Neoplasms
- Humans
- Genomic Instability
- Endoreduplication
- Cell Differentiation
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
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Fox, D. T., & Duronio, R. J. (2013). Endoreplication and polyploidy: insights into development and disease. Development, 140(1), 3–12. https://doi.org/10.1242/dev.080531
Fox, Donald T., and Robert J. Duronio. “Endoreplication and polyploidy: insights into development and disease.” Development 140, no. 1 (January 1, 2013): 3–12. https://doi.org/10.1242/dev.080531.
Fox DT, Duronio RJ. Endoreplication and polyploidy: insights into development and disease. Development. 2013 Jan 1;140(1):3–12.
Fox, Donald T., and Robert J. Duronio. “Endoreplication and polyploidy: insights into development and disease.” Development, vol. 140, no. 1, Jan. 2013, pp. 3–12. Pubmed, doi:10.1242/dev.080531.
Fox DT, Duronio RJ. Endoreplication and polyploidy: insights into development and disease. Development. 2013 Jan 1;140(1):3–12.
Published In
Development
DOI
EISSN
1477-9129
Publication Date
January 1, 2013
Volume
140
Issue
1
Start / End Page
3 / 12
Location
England
Related Subject Headings
- Polyploidy
- Plants
- Neoplasms
- Humans
- Genomic Instability
- Endoreduplication
- Cell Differentiation
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences