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Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.

Publication ,  Journal Article
Wu, JM; Ward, RM; Allen-Brady, KL; Edwards, TL; Norton, PA; Hartmann, KE; Hauser, ER; Velez Edwards, DR
Published in: Am J Obstet Gynecol
May 2013

Genetic epidemiology, the study of genetic contributions to risk for disease, is an innovative area in medicine. Although research in this arena has advanced in other disciplines, few genetic epidemiological studies have been conducted in obstetrics and gynecology. It is crucial that we study the genetic susceptibility for issues in women's health because this information will shape the new frontier of personalized medicine. To date, preterm birth may be one of the best examples of genetic susceptibility in obstetrics and gynecology, but many areas are being evaluated including endometriosis, fibroids, polycystic ovarian syndrome, and pelvic floor disorders. An essential component to genetic epidemiological studies is to characterize, or phenotype, the disorder to identify genetic effects. Given the growing importance of genomics and genetic epidemiology, we discuss the importance of accurate phenotyping of clinical disorders and highlight critical considerations and opportunities in phenotyping, using pelvic organ prolapse as a clinical example.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

May 2013

Volume

208

Issue

5

Start / End Page

360 / 365

Location

United States

Related Subject Headings

  • Risk Factors
  • Phenotype
  • Pelvic Organ Prolapse
  • Obstetrics & Reproductive Medicine
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Female
  • Confounding Factors, Epidemiologic
  • Age Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, J. M., Ward, R. M., Allen-Brady, K. L., Edwards, T. L., Norton, P. A., Hartmann, K. E., … Velez Edwards, D. R. (2013). Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am J Obstet Gynecol, 208(5), 360–365. https://doi.org/10.1016/j.ajog.2012.11.030
Wu, Jennifer M., Renée M. Ward, Kristina L. Allen-Brady, Todd L. Edwards, Peggy A. Norton, Katherine E. Hartmann, Elizabeth R. Hauser, and Digna R. Velez Edwards. “Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.Am J Obstet Gynecol 208, no. 5 (May 2013): 360–65. https://doi.org/10.1016/j.ajog.2012.11.030.
Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, et al. Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am J Obstet Gynecol. 2013 May;208(5):360–5.
Wu, Jennifer M., et al. “Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.Am J Obstet Gynecol, vol. 208, no. 5, May 2013, pp. 360–65. Pubmed, doi:10.1016/j.ajog.2012.11.030.
Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, Hauser ER, Velez Edwards DR. Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am J Obstet Gynecol. 2013 May;208(5):360–365.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

May 2013

Volume

208

Issue

5

Start / End Page

360 / 365

Location

United States

Related Subject Headings

  • Risk Factors
  • Phenotype
  • Pelvic Organ Prolapse
  • Obstetrics & Reproductive Medicine
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Female
  • Confounding Factors, Epidemiologic
  • Age Factors