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Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.

Publication ,  Journal Article
Petranka, JG; Fleenor, DE; Sykes, K; Kaufman, RE; Rosse, WF
Published in: Proc Natl Acad Sci U S A
September 1, 1992

The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases. The untranslated first exon is preceded by a G+C-rich promoter region that lacks a consensus TATA or CAAT motif. The second exon encodes the hydrophobic leader sequence of the protein, and the third exon encodes the amino-terminal portion of the mature protein. The fourth exon encodes the remainder of the mature protein, including the hydrophobic sequence necessary for glycosyl-phosphatidylinositol anchor attachment. The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity. The striking similarity in gene structure is further evidence that the two proteins belong to a superfamily of proteins that may also include the urokinase plasminogen-activator receptor and a squid glycoprotein of unknown function.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 1, 1992

Volume

89

Issue

17

Start / End Page

7876 / 7879

Location

United States

Related Subject Headings

  • Sequence Alignment
  • Restriction Mapping
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Membrane Glycoproteins
  • Humans
  • Genes
  • DNA
  • Cloning, Molecular
  • CD59 Antigens
 

Citation

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Petranka, J. G., Fleenor, D. E., Sykes, K., Kaufman, R. E., & Rosse, W. F. (1992). Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci U S A, 89(17), 7876–7879. https://doi.org/10.1073/pnas.89.17.7876
Petranka, J. G., D. E. Fleenor, K. Sykes, R. E. Kaufman, and W. F. Rosse. “Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.Proc Natl Acad Sci U S A 89, no. 17 (September 1, 1992): 7876–79. https://doi.org/10.1073/pnas.89.17.7876.
Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7876–9.
Petranka, J. G., et al. “Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.Proc Natl Acad Sci U S A, vol. 89, no. 17, Sept. 1992, pp. 7876–79. Pubmed, doi:10.1073/pnas.89.17.7876.
Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7876–7879.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 1, 1992

Volume

89

Issue

17

Start / End Page

7876 / 7879

Location

United States

Related Subject Headings

  • Sequence Alignment
  • Restriction Mapping
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Membrane Glycoproteins
  • Humans
  • Genes
  • DNA
  • Cloning, Molecular
  • CD59 Antigens