Russel E. Kaufman | Scholars@Duke

Russel E. Kaufman
Professor Emeritus of Medicine

The overall focus of this laboratory is the study of the genetic regulation of normal and leukemic hematopoietic cells. Hematopoietic stem cells are produced during embryonic and fetal development and migrate to fetal liver, spleen, thymus, and bone marrow to populate those organs for the "definitive" stages of hematopoiesis.

We have cloned and determined the structural organization of the human c-kit gene, normally expressed on erythroid progenitors, and identified important regulatory elements in its promoter. Furthermore, we have identified the ets transcription factors as mediators of its signaling pathway and have isolated a novel ets transcription factor, designated PE-2/ERF. Finally, we have cloned and characterized the human GATA-1 and GATA-2 genes and promoters and demonstrate that signaling through the Kit signal transduction pathway has direct effects on these genes, showing that Kit signal transduction in setting up the erythroid developmental program.

This laboratory also has isolated the gene encoding the T cell specific gene CD7, expressed in T cell progenitors. We have determined that the promoter has several motifs similar to the Thy-1 gene and lck gene and present in the murine CD7 gene. We have made transgenic mice carrying the human CD7 gene and find that it is expressed in a pattern similar to the murine gene. These studies and other biochemical studies have helped identify a region of the gene that binds a T cell specific transcription factor. This factor is now being characterized.

Key Words:Hematopoiesis, c-kit, ets, erythropoiesis, leukemia, gene regulation

for more information, see http:marini.biochem.duke.edu/Faculty/Kaufman.html

Current Appointments & Affiliations

Professor Emeritus of Medicine, Medicine, Medical Oncology, Medicine 2002

Contact Information

kaufm001@duke.edu

Background
Education, Training, & Certifications
- M.D., Ohio State University 1973
Duke Appointment History
- Professor of Medicine, Medicine, Medical Oncology, Medicine 1994 - 2002
- Vice Dean for Education and Academic Affairs, School of Medicine, Duke University 1999 - 2002
- Associate Vice Chancellor for Academic Affairs, School of Medicine, Duke University 2000 - 2002
- Professor of Biochemistry, Biochemistry, Basic Science Departments 2001 - 2002
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 1995 - 2001
- Vice Chair for Academic Programs and Development, Department of Medicine, Medicine, Clinical Science Departments 1995 - 1999
- Chief, Division of Medical Oncology in the Department of Medicine, Medicine, Clinical Science Departments 1989 - 1998
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 1994 - 1995
- Associate Professor of Medicine in the Department of Medicine, Medicine, Medical Oncology, Medicine 1987 - 1994
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1980 - 1987
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1977 - 1980
Research
Selected Grants
- Yr5 Role Of Platelet-Derived Growth Factor In The Pathogen awarded by National Institutes of Health 1993 - 2003
- Duke/Unc Comprehensive Sickle Cell Center awarded by National Institutes of Health 1977 - 2000
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Research Training In Cancer Biology And Therapy awarded by National Institutes of Health 1978 - 1998
- Research Training In Cancer Biology And Therapy awarded by National Institutes of Health 1978 - 1998
- Comprhensive Sickle Cell Center awarded by National Institutes of Health 1977 - 1998
- Creation Of A Center In Molecular Hematology awarded by National Institutes of Health 1993 - 1994
- Control Of The Hematopoietic Developmental Programs awarded by National Institutes of Health 1991 - 1993
- Control Of The Hematopoietic Development Program (Suppleme awarded by National Institutes of Health 1990 - 1992
- Control Of The Hematopoietic Developmental Program awarded by National Institutes of Health 1987 - 1992
- Characterization Of Genes For Human Type I Collagen awarded by National Institutes of Health 1985 - 1987
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kaufman, Russel E. “Symposium in Honor of Hilary Koprowski's Scientific Achievements..” J Infect Dis 212 Suppl 1 (July 15, 2015). https://doi.org/10.1093/infdis/jiv242.
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  - Wang, Tao, Min Xiao, Yingbin Ge, Clemens Krepler, Eric Belser, Alfonso Lopez-Coral, Xiaowei Xu, et al. “BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth..” Clin Cancer Res 21, no. 7 (April 1, 2015): 1652–64. https://doi.org/10.1158/1078-0432.CCR-14-1554.
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  - Wang, T., G. M. Feldman, M. Herlyn, and R. E. Kaufman. “The macrophage: Switches from a passenger to a driver during anticancer therapy.” Oncoimmunology 4, no. 12 (January 1, 2015). https://doi.org/10.1080/2162402X.2015.1052929.
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  - Wang, Tao, Yingbin Ge, Min Xiao, Alfonso Lopez-Coral, Ling Li, Alexander Roesch, Catherine Huang, et al. “SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway..” J Invest Dermatol 134, no. 4 (April 2014): 1108–18. https://doi.org/10.1038/jid.2013.437.
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  - Ge, Y., R. Azuma, B. Gekonge, A. Lopez-Coral, M. Xiao, G. Zhang, X. Xu, et al. “Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation.” Frontiers in Biology 7, no. 4 (August 1, 2012): 359–67. https://doi.org/10.1007/s11515-012-1237-8.
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  - Wang, Tao, Yingbin Ge, Min Xiao, Alfonso Lopez-Coral, Rikka Azuma, Rajasekharan Somasundaram, Gao Zhang, et al. “Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature..” Pigment Cell Melanoma Res 25, no. 4 (July 2012): 493–505. https://doi.org/10.1111/j.1755-148X.2012.01005.x.
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  - Wang, Tao, Catherine Huang, Alfonso Lopez-Coral, Kimberly A. Slentz-Kesler, Min Xiao, E John Wherry, and Russel E. Kaufman. “K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation..” J Leukoc Biol 91, no. 3 (March 2012): 449–59. https://doi.org/10.1189/jlb.1011498.
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  - Patel, A. A., J. R. Gilbertson, L. C. Showe, J. W. London, E. Ross, M. F. Ochs, J. Carver, et al. “A novel cross-disciplinary multi-institute approach to translational cancer research: Lessons learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC).” Cancer Informatics 3 (December 1, 2007): 255–74.
  - Lam, Gordon K., Hua-Xin Liao, Yan Xue, S Munir Alam, Richard M. Scearce, Russel E. Kaufman, Gregory D. Sempowski, and Barton F. Haynes. “Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma..” J Clin Immunol 25, no. 1 (January 2005): 41–49. https://doi.org/10.1007/s10875-005-0356-5.
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  - Danforth, W., J. T. Bigger, F. Davidoff, M. Delaney, S. Dentzer, S. H. Ehringhaus, G. Graham, et al. “Protecting subjects, preserving trust, promoting progress II: Principles and recommendations for oversight of an institution's financial interests in human subjects research.” Academic Medicine 78, no. 2 (February 2003): 237–45.
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  - Danforth, W., J. T. Bigger, F. Davidoff, M. J. Delaney, S. Dentzer, S. H. Ehringhaus, G. Graham, et al. “Protecting subjects, preserving trust, promoting progress I: Policy and guidelines for the oversight of individual financial interests in human subjects research.” Academic Medicine 78, no. 2 (February 2003): 226–36.
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  - Manousos, G. A., Y. Xue, J. Dawson, and R. E. Kaufman. “Regulation of T and NK cell mediated cytotoxicity by the CD7 ligand, k12..” Blood 98, no. 11 (November 16, 2001): 23A-23A.
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  - Lam, G. K., H. X. Liao, Y. Xue, S. M. Alam, J. R. Thomasch, G. D. Sempowski, S. H. Stauffer, R. Kaufman, and B. F. Haynes. “Characterisation and expression of CD7 ligand, K-12, in human thymic epithelial cells.” Faseb Journal 15, no. 5 (March 8, 2001): A1033–A1033.
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  - Kaufman, R. E. “Synthesis of sickle and normal hemoglobins: Laboratory and clinical implications.” Laboratory Medicine 30, no. 2 (January 1, 1999): 129–33. https://doi.org/10.1093/labmed/30.2.129.
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  - Sempowski, G. D., D. M. Lee, R. E. Kaufman, and B. F. Haynes. “Structure and function of the CD7 molecule..” Crit Rev Immunol 19, no. 4 (1999): 331–48.
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  - Slentz-Kesler, K. A., L. P. Hale, and R. E. Kaufman. “Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms..” Genomics 47, no. 3 (February 1, 1998): 327–40. https://doi.org/10.1006/geno.1997.5151.
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  - Langdon, S. D., and R. E. Kaufman. “Gamma-globin gene promoter elements required for interaction with globin enhancers..” Blood 91, no. 1 (January 1, 1998): 309–18.
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  - Castro, C. M. de, S. M. Rabe, S. D. Langdon, D. E. Fleenor, K. Slentz-Kesler, M. N. Ahmed, M. B. Qumsiyeh, and R. E. Kaufman. “Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)..” Genomics 42, no. 2 (June 1, 1997): 227–35. https://doi.org/10.1006/geno.1997.4730.
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  - Ratech, H., S. Denning, and R. E. Kaufman. “An analysis of alternatively spliced CD45 mRNA transcripts during T cell maturation in humans..” Cell Immunol 177, no. 2 (May 1, 1997): 109–18. https://doi.org/10.1006/cimm.1997.1111.
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  - Fleenor, D. E., L. E. Schanberg, and R. E. Kaufman. “A conserved element in the human CD7 promoter binds dbpA and a novel zinc finger protein..” Blood 88, no. 10 (November 15, 1996): 770–770.
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  - Langdon, S. D., and R. E. Kaufman. “Gamma globin promoter elements required for interaction with globin enhancers..” Blood 88, no. 10 (November 15, 1996): 595–595.
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  - SlentzKesler, K., and R. E. Kaufman. “Characterization of K12, a novel molecule with potential growth promoting activity produced by granulocytes.” Blood 88, no. 10 (November 15, 1996): 65–65.
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  - deCastro, C. M., S. M. Rabe, S. D. Langdon, D. E. Fleenor, and R. E. Kaufman. “PE-2 (ERF), a novel ETS factor, is hypophosphorylated in c-kit(+) K562 cells..” Blood 88, no. 10 (November 15, 1996): 3183–3183.
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  - Fleenor, D. E., S. D. Langdon, C. M. deCastro, and R. E. Kaufman. “Comparison of human and Xenopus GATA-2 promoters..” Gene 179, no. 2 (November 14, 1996): 219–23. https://doi.org/10.1016/s0378-1119(96)00355-1.
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  - Vandenbark, G. R., Y. Chen, E. Friday, K. Pavlik, B. Anthony, C. deCastro, and R. E. Kaufman. “Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements..” Cell Growth Differ 7, no. 10 (October 1996): 1383–92.
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  - Lee, D. M., L. E. Schanberg, D. E. Fleenor, M. F. Seldin, B. F. Haynes, and R. E. Kaufman. “The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters..” Immunogenetics 44, no. 2 (1996): 108–14.
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  - Sundv, J. S., T. S. Barry, D. D. Patel, N. B. Allen, B. Devlin, S. Bigner, R. E. Kaufman, and B. F. Haynes. “Myotropic Th1 T helper cell lymphoma presenting as granulomatous inflammatory masses in synovium and muscle.” Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
  - deCastro, C. M., S. Rabe, S. D. Langdon, and R. E. Kaufman. “Isolation and characterization of a novel ETS factor, PE-2..” Blood 86, no. 10 (November 15, 1995): 2632–2632.
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  - Schanberg, L. E., D. M. Lee, D. E. Fleenor, R. E. Ware, D. D. Patel, B. F. Haynes, and R. E. Kaufman. “Characterization of human CD7 transgenic mice..” J Immunol 155, no. 5 (September 1, 1995): 2407–18.
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  - LEE, D. M., M. F. SELDIN, R. E. KAUFMAN, and B. F. HAYNES. “GENETIC AND BIOCHEMICAL-CHARACTERIZATION OF MOUSE CD7 - IDENTIFICATION OF A NOVEL PROMOTER SEQUENCE.” Faseb Journal 9, no. 3 (March 9, 1995): A233–A233.
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  - Devlin, B. H., H. Ratech, and R. Kaufman. “Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies..” Diagn Mol Pathol 3, no. 4 (December 1994): 271–74.
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  - deCastro, C. M., S. M. Denning, S. Langdon, G. R. Vandenbark, J. Kurtzberg, R. Scearce, B. F. Haynes, and R. E. Kaufman. “The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes..” Exp Hematol 22, no. 10 (September 1994): 1025–33.
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  - Castro, C. M. de, B. Devlin, D. E. Fleenor, M. E. Lee, and R. E. Kaufman. “A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype..” Blood 83, no. 4 (February 15, 1994): 1109–16.
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  - DECASTRO, C. M., B. DEVLIN, D. E. FLEENOR, M. LEE, and R. E. KAUFMAN. “COMPUTER IMAGING OF BETA-DURHAM-NC [BETA(114) LEU-]PRO], A THALASSEMIC HEMOGLOBINOPATHY.” Blood 82, no. 10 (November 15, 1993): A358–A358.
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  - DECASTRO, C. M., S. M. DENNING, S. LANGDON, J. KURTZBERG, R. SCEARCE, B. F. HAYNES, and R. E. KAUFMAN. “EXPRESSION OF C-KIT RECEPTORS AND KIT-LIGAND IN HUMAN THYMOCYTES AND THYMUS TISSUE.” Blood 82, no. 10 (November 15, 1993): A244–A244.
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  - RATECH, H., S. DENNING, and R. E. KAUFMAN. “REGULATION OF ALTERNATIVELY SPLICED CD45 MESSENGER-RNA TRANSCRIPTS DURING T-CELL MATURATION.” Blood 82, no. 10 (November 15, 1993): A244–A244.
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  - Bowen, D. T., R. A. Padua, A. K. Burnett, C. M. deCastro, and R. E. Kaufman. “Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots..” Leukemia 7, no. 11 (November 1993): 1883–85.
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  - Bentley, R. C., B. Devlin, R. E. Kaufman, M. Borowitz, and H. Ratech. “Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes..” Hum Pathol 24, no. 6 (June 1993): 675–78. https://doi.org/10.1016/0046-8177(93)90249-g.
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  - Fleenor, D. E., and R. E. Kaufman. “Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain..” Blood 81, no. 10 (May 15, 1993): 2781–90.
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  - FLEENOR, D. E., and R. E. KAUFMAN. “INSULATION OF THE BETA-GLOBIN GENE DOMAIN.” Clinical Research 41, no. 2 (April 1993): A206–A206.
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  - GAUTIER, M., C. DECASTRO, S. LANGDON, M. OSTROWSKI, and R. E. KAUFMAN. “REPROGRAMMING OF HEMIN INDUCED-DIFFERENTIATION BY ETS-LAC Z.” Clinical Research 41, no. 2 (April 1993): A306–A306.
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  - Bowen, D. T., R. A. Padua, A. K. Burnett, C. M. DeCastro, and R. E. Kaufman. “Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.” Leukemia 7, no. 11 (January 1, 1993): 1883–85.
  - BARRY, T. S., K. E. RENDT, D. M. JONES, R. E. WARE, C. B. RICHTER, S. S. MCCACHREN, B. DEVLIN, R. E. KAUFMAN, and B. F. HAYNES. “ENGRAFTMENT OF HUMAN SYNOVIUM INTO SEVERE COMBINED IMMUNE DEFICIENT (SCID) MICE - MIGRATION OF HUMAN PERIPHERAL-BLOOD T-CELLS TO ENGRAFTED HUMAN SYNOVIUM.” Arthritis and Rheumatism 35, no. 9 (September 1, 1992): S45–S45.
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  - Petranka, J. G., D. E. Fleenor, K. Sykes, R. E. Kaufman, and W. F. Rosse. “Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein..” Proc Natl Acad Sci U S A 89, no. 17 (September 1, 1992): 7876–79. https://doi.org/10.1073/pnas.89.17.7876.
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  - Vandenbark, G. R., C. M. deCastro, H. Taylor, S. Dew-Knight, and R. E. Kaufman. “Cloning and structural analysis of the human c-kit gene..” Oncogene 7, no. 7 (July 1992): 1259–66.
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  - Kaufman, R. E. “Hydroxyurea: specific therapy for sickle cell anemia?.” Blood 79, no. 10 (May 15, 1992): 2503–6.
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  - DECASTRO, C. M., G. R. VANDENBARK, and R. E. KAUFMAN. “DETECTION OF THE KIT PROTOONCOGENE RECEPTOR ON HUMAN HEMATOPOIETIC PROGENITOR CELLS USING THE MONOCLONAL-ANTIBODY 9B9.” Experimental Hematology 20, no. 1 (January 1992): 111–111.
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  - Tyson, F. L., C. M. Boyer, R. Kaufman, K. O’Briant, G. Cram, J. R. Crews, J. T. Soper, L. Daly, W. C. Fowler, and J. S. Haskill. “Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines..” Am J Obstet Gynecol 165, no. 3 (September 1991): 640–46. https://doi.org/10.1016/0002-9378(91)90300-g.
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  - Schanberg, L. E., D. E. Fleenor, J. Kurtzberg, B. F. Haynes, and R. E. Kaufman. “Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene..” Proc Natl Acad Sci U S A 88, no. 2 (January 15, 1991): 603–7. https://doi.org/10.1073/pnas.88.2.603.
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  - Meadows, L. M., D. J. George, and R. E. Kaufman. “Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells..” J Biol Response Mod 9, no. 2 (April 1990): 212–20.
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  - Sykes, K., and R. Kaufman. “A naturally occurring gamma globin gene mutation enhances SP1 binding activity..” Mol Cell Biol 10, no. 1 (January 1990): 95–102. https://doi.org/10.1128/mcb.10.1.95.
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  - Meadows, L. M., W. R. Rosse, J. O. Moore, J. Crawford, J. Laszlo, and R. E. Kaufman. “Hodgkin's disease presenting as myelofibrosis..” Cancer 64, no. 8 (October 15, 1989): 1720–26. https://doi.org/10.1002/1097-0142(19891015)64:8<1720::aid-cncr2820640828>3.0.co;2-l.
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  - KINNEY, T. R., M. SAWTSCHENKO, M. WHORTON, J. SHEARIN, C. STINE, L. HOFMAN, R. SAFKO, T. VITAGLIONE, and R. E. KAUFMAN. “TECHNIQUES COMPARISON AND REPORT OF THE NORTH-CAROLINA EXPERIENCE.” Pediatrics 83, no. 5 (May 1, 1989): 843–48.
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  - Kinney, T. R., M. Sawtschenko, M. Whorton, J. Shearin, C. Stine, L. Hofman, R. Safko, T. Vitaglione, and R. E. Kaufman. “Newborn screening for sickle cell disease and other hemoglobinopathies. Techniques' comparison and report of the North Carolina experience..” Pediatrics 83, no. 5 Pt 2 (May 1989): 843–48.
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  - KAUFMAN, R. E. “CHARACTERIZATION OF AN ERYTHROID DNASE-I SUPERSENSITIVE SITE.” Clinical Research 37, no. 2 (April 1989): A374–A374.
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  - Kinney, T. R., M. Sawtschenko, M. Whorton, J. Shearin, C. Stine, L. Hofman, R. Safko, T. Vitaglione, and R. E. Kaufman. “Techniques' comparison and report of the North Carolina experience.” Pediatrics 83, no. 5 SUPPL. (January 1, 1989): 843–48.
  - Sykes, K., and R. Kaufman. “A human gamma globin gene variant binds SP1..” Prog Clin Biol Res 316A (1989): 237–46.
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  - Phillips, G., J. Hartman, T. R. Kinney, J. E. Sokal, and R. E. Kaufman. “Chronic granulocytic leukemia in a patient with sickle cell anemia..” Am J Med 85, no. 4 (October 1988): 567–69. https://doi.org/10.1016/s0002-9343(88)80100-1.
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  - Ortel, T. L., J. J. Onorato, C. L. Bedrosian, and R. E. Kaufman. “Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome..” Am J Hematol 29, no. 1 (September 1988): 44–48. https://doi.org/10.1002/ajh.2830290111.
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  - Markert, M. L., J. J. Hutton, D. A. Wiginton, J. C. States, and R. E. Kaufman. “Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements..” J Clin Invest 81, no. 5 (May 1988): 1323–27. https://doi.org/10.1172/JCI113458.
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  - Geesin, J. C., D. Darr, R. Kaufman, S. Murad, and S. R. Pinnell. “Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast..” J Invest Dermatol 90, no. 4 (April 1988): 420–24. https://doi.org/10.1111/1523-1747.ep12460849.
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  - TAJIMA, S., C. PHILLIPS, S. MURAD, R. KAUFMAN, and S. PINNELL. “TRANSCRIPTIONAL REGULATION OF PROCOLLAGEN SYNTHESIS BY ASCORBIC-ACID.” Clinical Research 36, no. 3 (April 1988): A697–A697.
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  - TAJIMA, S., C. PHILLIPS, S. MURAD, R. KAUFMAN, and S. PINNELL. “TRANSCRIPTIONAL REGULATION OF PROCOLLAGEN SYNTHESIS BY ASCORBIC-ACID.” Journal of Investigative Dermatology 90, no. 4 (April 1988): 611–611.
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  - KAUFMAN, R. E., S. STINNETT, and G. PHILLIPS. “A MUTATION AT POSITION-158 OF THE G-GAMMA GLOBIN GENE IS LINKED TO BETA-THALASSEMIA INTERMEDIA.” Clinical Research 36, no. 1 (January 1988): A16–A16.
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  - Dickey, L. F., S. Sreedharan, E. C. Theil, J. R. Didsbury, Y. H. Wang, and R. E. Kaufman. “Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia..” J Biol Chem 262, no. 16 (June 5, 1987): 7901–7.
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  - Markert, M. L., M. S. Hershfield, D. A. Wiginton, J. C. States, F. E. Ward, S. H. Bigner, R. H. Buckley, R. E. Kaufman, and J. J. Hutton. “Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency..” J Immunol 138, no. 10 (May 15, 1987): 3203–6.
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  - KAUFMAN, R. E. “CHARACTERIZATION OF FETAL-TYPE ACETYLCHOLINESTERASE IN HEMIN-TREATED K562 CELL-CULTURE - COMMENTARY.” Blood Cells 12, no. 3 (1987): 653–55.
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  - Introna, M., T. A. Hamilton, R. E. Kaufman, D. O. Adams, and R. C. Bast. “Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes..” J Immunol 137, no. 8 (October 15, 1986): 2711–15.
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  - McCachren, S. S., J. Nichols, R. E. Kaufman, and J. E. Niedel. “Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation..” Blood 68, no. 2 (August 1986): 412–16.
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  - SREEDHARAN, S. P., J. R. DIDSBURY, E. C. THEIL, A. R. MCKENZIE, and R. E. KAUFMAN. “CHARACTERIZATION OF A TADPOLE (RANA-CATESBEIANA) RED-CELL FERRITIN L-SUBUNIT MESSENGER-RNA.” Federation Proceedings 45, no. 6 (May 1986): 1699–1699.
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  - WANG, Y. H., J. R. DIDSBURY, L. DICKEY, E. C. THEIL, and R. E. KAUFMAN. “3 DIFFERENT CDNAS CODING FOR EMBRYONIC BETA-GLOBIN OF THE BULLFROG, RANA-CATESBEIANA.” Federation Proceedings 45, no. 6 (May 1986): 1698–1698.
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  - Didsbury, J. R., E. C. Theil, R. E. Kaufman, and L. F. Dickey. “Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions..” J Biol Chem 261, no. 2 (January 15, 1986): 949–55.
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  - Williams, R. S., S. Salmons, E. A. Newsholme, R. E. Kaufman, and J. Mellor. “Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle..” J Biol Chem 261, no. 1 (January 5, 1986): 376–80.
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  - INTRONA, M., T. A. HAMILTON, R. E. KAUFMAN, G. STRASSMAN, D. O. ADAMS, and R. C. BAST. “FUNCTIONAL ACTIVATION OF MURINE PERITONEAL-MACROPHAGES WITH BACTERIAL LIPOPOLYSACCHARIDE ALTERS EXPRESSION OF C-FOS AND C-MYC ONCOGENES.” Journal of Cellular Biochemistry, January 1, 1986, 21–21.
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  - KAUFMAN, R. E. “PROTOONCOGENES AS REGULATORS OF GROWTH AND DIFFERENTIATION.” Journal of Neuro Oncology 4, no. 1 (1986): 92–92.
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  - Grobler-Rabie, A. F., D. K. Brebner, S. Vandenplas, G. Wallis, R. Dalgleish, R. E. Kaufman, A. J. Bester, C. G. Mathew, and C. D. Boyd. “Polymorphism of DNA sequence in the human pro alpha 2(I) collagen gene..” J Med Genet 22, no. 3 (June 1985): 182–86. https://doi.org/10.1136/jmg.22.3.182.
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  - Atweh, G. F., N. P. Anagnou, J. Shearin, B. G. Forget, and R. E. Kaufman. “Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site..” Nucleic Acids Res 13, no. 3 (February 11, 1985): 777–90. https://doi.org/10.1093/nar/13.3.777.
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  - Henke, E., M. Leader, S. Tajima, S. Pinnell, and R. Kaufman. “A 38 base pair insertion in the pro alpha 2(I) collagen gene of a patient with Marfan syndrome..” J Cell Biochem 27, no. 2 (1985): 169–74. https://doi.org/10.1002/jcb.240270210.
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  - KAUFMAN, R., E. HENKE, M. DUVIC, F. BISAT, and S. PINNELL. “Normal and Mutant Human Collagen Genes.” Annals of the New York Academy of Sciences 460, no. 1 (January 1, 1985): 461–62. https://doi.org/10.1111/j.1749-6632.1985.tb51209.x.
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  - Lobach, D. F., D. P. Bolognesi, and R. E. Kaufman. “Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus..” Cancer Invest 3, no. 2 (1985): 145–60. https://doi.org/10.3109/07357908509017497.
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  - Tajima, S., J. P. Ting, S. R. Pinnell, and R. E. Kaufman. “Isolation and characterization of a human pro alpha 2(I) collagen gene segment..” J Invest Dermatol 82, no. 3 (March 1984): 265–69. https://doi.org/10.1111/1523-1747.ep12260213.
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  - DUVIC, M., S. PINNELL, and R. KAUFMAN. “LOCALIZATION OF THE 5' END OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE.” Clinical Research 32, no. 2 (1984): A580–A580.
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  - DUVIC, M., S. PINNELL, and R. KAUFMAN. “LOCALIZATION OF THE 5' END OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE.” Journal of Investigative Dermatology 82, no. 4 (1984): 440–440.
    Link to Item
  - HENKE, E., S. PINNELL, and R. KAUFMAN. “A 38 BASE PAIR INSERTION IN THE PRO-ALPHA-2(I) COLLAGEN GENE OF A PATIENT WITH MARFAN-SYNDROME.” Clinical Research 32, no. 2 (January 1, 1984): A492–A492.
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  - NICHOLS, J., C. CHUA, and R. KAUFMAN. “CLASSES OF AMPLIFIED C-MYC GENES IN HL60.” Clinical Research 32, no. 2 (January 1, 1984): A420–A420.
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  - ATWEH, G. F., D. SANE, and R. E. KAUFMAN. “CHARACTERIZATION OF THE DELETION IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN.” Clinical Research 31, no. 2 (1983): A308–A308.
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  - DUVIC, M., J. TING, S. TAJIMA, R. KAUFMAN, and S. PINNELL. “CHARACTERIZATION OF THE HUMAN-ALPHA-(I) COLLAGEN GENE.” Clinical Research 31, no. 2 (1983): A563–A563.
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  - DUVIC, M., J. TING, S. TAJIMA, R. KAUFMAN, and S. PINNELL. “CHARACTERIZATION OF THE HUMAN ALPHA-2(I) COLLAGEN GENE.” Journal of Investigative Dermatology 80, no. 4 (1983): 303–303.
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  - DUVIC, M., S. PINNELL, and R. KAUFMAN. “LOCALIZATION OF THE 5' AND OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE.” Clinical Research 31, no. 5 (1983): A834–A834.
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  - RILEY, E., S. TAJIMA, R. KAUFMAN, and S. PINNELL. “RESTRICTION ENZYME MAPPING OF THE PRO ALPHA-2 (I) GENE IN A PATIENT WITH THE MARFAN-SYNDROME.” Clinical Research 31, no. 2 (1983): A598–A598.
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  - RILEY, E., S. TAJIMA, R. KAUFMAN, and S. PINNELL. “RESTRICTION ENZYME MAPPING OF THE PRO-ALPHA2-(I) GENE IN A PATIENT WITH THE MARFAN-SYNDROME.” Journal of Investigative Dermatology 80, no. 4 (1983): 314–314.
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  - KAUFMAN, R. E. “CHARACTERIZATION OF THE 3' END OF THE DELETION IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN (HPFH).” Clinical Research 30, no. 2 (1982): A320–A320.
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  - TAJIMA, S., R. E. KAUFMAN, and S. R. PINNELL. “ISOLATION AND PARTIAL CHARACTERIZATION OF HUMAN GENOMIC DNA FOR THE PRO ALPHA-2 (I) COLLAGEN CHAIN.” Clinical Research 30, no. 2 (1982): A611–A611.
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  - TAJIMA, S., R. E. KAUFMAN, and S. R. PINNELL. “ISOLATION AND PARTIAL CHARACTERIZATION OF HUMAN GENOMIC DNA FOR THE PRO ALPHA-2 (I) COLLAGEN CHAIN.” Journal of Investigative Dermatology 78, no. 4 (1982): 344–45.
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- Conference Papers
  - Laughlin, M. J., K. McKinnon, J. Demarest, C. M. Koropchak, K. Weinhold, H. K. Lyerly, E. Gilboa, et al. “Generation of autologous CD4+ T lymphocyte clones specific for precursor-B (pre-B) lymphoblasts via dendritic cell (DC) presentation.” In Blood, 90:826–826. W B SAUNDERS CO, 1997.
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