Russel E. Kaufman | Scholars@Duke

Russel E. Kaufman
Professor Emeritus of Medicine

The overall focus of this laboratory is the study of the genetic regulation of normal and leukemic hematopoietic cells. Hematopoietic stem cells are produced during embryonic and fetal development and migrate to fetal liver, spleen, thymus, and bone marrow to populate those organs for the "definitive" stages of hematopoiesis.

We have cloned and determined the structural organization of the human c-kit gene, normally expressed on erythroid progenitors, and identified important regulatory elements in its promoter. Furthermore, we have identified the ets transcription factors as mediators of its signaling pathway and have isolated a novel ets transcription factor, designated PE-2/ERF. Finally, we have cloned and characterized the human GATA-1 and GATA-2 genes and promoters and demonstrate that signaling through the Kit signal transduction pathway has direct effects on these genes, showing that Kit signal transduction in setting up the erythroid developmental program.

This laboratory also has isolated the gene encoding the T cell specific gene CD7, expressed in T cell progenitors. We have determined that the promoter has several motifs similar to the Thy-1 gene and lck gene and present in the murine CD7 gene. We have made transgenic mice carrying the human CD7 gene and find that it is expressed in a pattern similar to the murine gene. These studies and other biochemical studies have helped identify a region of the gene that binds a T cell specific transcription factor. This factor is now being characterized.

Key Words:Hematopoiesis, c-kit, ets, erythropoiesis, leukemia, gene regulation

for more information, see http:marini.biochem.duke.edu/Faculty/Kaufman.html

Current Appointments & Affiliations

Professor Emeritus of Medicine, Medicine, Medical Oncology, Medicine 2002

Contact Information

kaufm001@duke.edu

Background
Education, Training, & Certifications
- M.D., Ohio State University 1973
Duke Appointment History
- Professor of Medicine, Medicine, Medical Oncology, Medicine 1994 - 2002
- Vice Dean for Education and Academic Affairs, School of Medicine, Duke University 1999 - 2002
- Associate Vice Chancellor for Academic Affairs, School of Medicine, Duke University 2000 - 2002
- Professor of Biochemistry, Biochemistry, Basic Science Departments 2001 - 2002
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 1995 - 2001
- Vice Chair for Academic Programs and Development, Department of Medicine, Medicine, Clinical Science Departments 1995 - 1999
- Chief, Division of Medical Oncology in the Department of Medicine, Medicine, Clinical Science Departments 1989 - 1998
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 1994 - 1995
- Associate Professor of Medicine in the Department of Medicine, Medicine, Medical Oncology, Medicine 1987 - 1994
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1980 - 1987
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1977 - 1980
Research
Selected Grants
- Yr5 Role Of Platelet-Derived Growth Factor In The Pathogen awarded by National Institutes of Health 1993 - 2003
- Duke/Unc Comprehensive Sickle Cell Center awarded by National Institutes of Health 1977 - 2000
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Research Training In Cancer Biology And Therapy awarded by National Institutes of Health 1978 - 1998
- Research Training In Cancer Biology And Therapy awarded by National Institutes of Health 1978 - 1998
- Comprhensive Sickle Cell Center awarded by National Institutes of Health 1977 - 1998
- Creation Of A Center In Molecular Hematology awarded by National Institutes of Health 1993 - 1994
- Control Of The Hematopoietic Developmental Programs awarded by National Institutes of Health 1991 - 1993
- Control Of The Hematopoietic Development Program (Suppleme awarded by National Institutes of Health 1990 - 1992
- Control Of The Hematopoietic Developmental Program awarded by National Institutes of Health 1987 - 1992
- Characterization Of Genes For Human Type I Collagen awarded by National Institutes of Health 1985 - 1987
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kaufman, RE. "Symposium in Honor of Hilary Koprowski's Scientific Achievements." The Journal of infectious diseases 212 Suppl 1 (July 2015): S1-. Full Text
  - Wang, T, Xiao, M, Ge, Y, Krepler, C, Belser, E, Lopez-Coral, A, Xu, X, Zhang, G, Azuma, R, Liu, Q, Liu, R, Li, L, Amaravadi, RK, Xu, W, Karakousis, G, Gangadhar, TC, Schuchter, LM, Lieu, M, Khare, S, Halloran, MB, Herlyn, M, and Kaufman, RE. "BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 21, no. 7 (April 2015): 1652-1664. Full Text
  - Wang, T, Feldman, GM, Herlyn, M, and Kaufman, RE. "The macrophage: Switches from a passenger to a driver during anticancer therapy." Oncoimmunology 4, no. 12 (January 1, 2015). Full Text
  - Wang, T, Ge, Y, Xiao, M, Lopez-Coral, A, Li, L, Roesch, A, Huang, C, Alexander, P, Vogt, T, Xu, X, Hwang, W-T, Lieu, M, Belser, E, Liu, R, Somasundaram, R, Herlyn, M, and Kaufman, RE. "SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway." The Journal of investigative dermatology 134, no. 4 (April 2014): 1108-1118. Full Text
  - Ge, Y, Azuma, R, Gekonge, B, Lopez-Coral, A, Xiao, M, Zhang, G, Xu, X, Montaner, LJ, Wei, Z, Herlyn, M, Wang, T, and Kaufman, RE. "Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation." Frontiers in Biology 7, no. 4 (August 1, 2012): 359-367. Full Text
  - Wang, T, Ge, Y, Xiao, M, Lopez-Coral, A, Azuma, R, Somasundaram, R, Zhang, G, Wei, Z, Xu, X, Rauscher, FJ, Herlyn, M, and Kaufman, RE. "Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature." Pigment Cell & Melanoma Research 25, no. 4 (July 2012): 493-505. Full Text
  - Wang, T, Huang, C, Lopez-Coral, A, Slentz-Kesler, KA, Xiao, M, Wherry, EJ, and Kaufman, RE. "K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation." Journal of leukocyte biology 91, no. 3 (March 2012): 449-459. Full Text
  - Patel, AA, Gilbertson, JR, Showe, LC, London, JW, Ross, E, Ochs, MF, Carver, J, Lazarus, A, Parwani, AV, Dhir, R, Beck, JR, Liebman, M, Garcia, FU, Prichard, J, Wilkerson, M, Herberman, RB, Becich, MJ, Whelan, N, Mathews, L, Winters, S, Urda, S, Gianella, H, Bisceglia, M, Gupta, R, Singh, H, Li, S, Nie, Y, Chu, V, Mohanty, S, Mann, D, Mignogna, L, Monzon-Bordonaba, F, Katsur, A, Kirkwood, J, Brufsky, A, Colecchia, T, Green, C, Glick, J, Tigges, J, Fenstermacher, D, Rebbeck, TR, DeMichele, A, Weber, B, Guerry, DP, Poppert, E, Haney, K, Brusstar, S, Malick, J, Capriotti, A, Balshem, A, Uzzo, RG, Goldstein, LJ, Lessin, SR, Harsche, P, London, WT, Davidson, RL, DeBaca, M, Orrico, AR, Hannes, A, Palazzo, JP, Dicker, A, Mastrangelo, M, Chou, K, Loughran, T, Whayland, P, Swetland, P, Lazarus, P, Harriet, I, Beard, D, Snyder, AJ, Rybka, WB, Lorence, D, Lipton, A, Harvey, HA, Robertson, G, Claxton, D, Rauscher, R, Carlisle, J, Kaufman, RE, Ewert, D, O'Brien, E, Melnicoff, M, Blank, K, Hailu, T, Petushi, S, Steele, GD, Buckley, S, Hunter, N, Yantus, K, Hu, H, Sheridan, C, Rigby, H, Jacobs, FN, Bronder, P, Palmer, D, and Glick, JH. "A novel cross-disciplinary multi-institute approach to translational cancer research: Lessons learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)." Cancer Informatics 3 (December 1, 2007): 255-274.
  - Lam, GK, Liao, H-X, Xue, Y, Alam, SM, Scearce, RM, Kaufman, RE, Sempowski, GD, and Haynes, BF. "Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma." Journal of Clinical Immunology 25, no. 1 (January 2005): 41-49. Full Text
  - Danforth, W, Bigger, JT, Davidoff, F, Delaney, M, Dentzer, S, Ehringhaus, SH, Graham, G, Hellmann, S, Kahn, J, Kalb, M, Kaufman, RE, Kelch, RP, Laret, MR, Leonard, JS, Levy, R, Lieber, CE, Martin, JB, Miller, ED, Murray, TH, O'Brien, CP, Porter, JE, Porter, R, Ramsey, PG, Robinson, DK, Visco, FM, Woo, S, Wood, AJJ, Turman, RJ, Korn, D, Kulynych, J, and Conflict, AAMCTFF. "Protecting subjects, preserving trust, promoting progress II: Principles and recommendations for oversight of an institution's financial interests in human subjects research." ACADEMIC MEDICINE 78, no. 2 (February 2003): 237-245. Link to Item
  - Danforth, W, Bigger, JT, Davidoff, F, Delaney, MJ, Dentzer, S, Ehringhaus, SH, Graham, G, Hellmann, S, Kahn, J, Kalb, M, Kaufman, RE, Kelch, RP, Laret, MR, Leonard, JS, Levy, R, Lieber, CE, Martin, JB, Miller, ED, Murray, TH, O'Brien, CP, Porter, JE, Porter, R, Ramsey, PG, Robinson, DK, Smith, H, Visco, FM, Woo, S, Wood, AJJ, Turman, RJ, Korn, D, Kulynych, J, and Conflict, AAMCTFF. "Protecting subjects, preserving trust, promoting progress I: Policy and guidelines for the oversight of individual financial interests in human subjects research." ACADEMIC MEDICINE 78, no. 2 (February 2003): 226-236. Link to Item
  - Manousos, GA, Xue, Y, Dawson, J, and Kaufman, RE. "Regulation of T and NK cell mediated cytotoxicity by the CD7 ligand, k12." BLOOD 98, no. 11 (November 16, 2001): 23A-23A. Link to Item
  - Lam, GK, Liao, HX, Xue, Y, Alam, SM, Thomasch, JR, Sempowski, GD, Stauffer, SH, Kaufman, R, and Haynes, BF. "Characterisation and expression of CD7 ligand, K-12, in human thymic epithelial cells." Faseb Journal 15, no. 5 (March 8, 2001): A1033-A1033. Link to Item
  - Kaufman, RE. "Synthesis of sickle and normal hemoglobins: Laboratory and clinical implications." Laboratory Medicine 30, no. 2 (January 1, 1999): 129-133. Full Text
  - Sempowski, GD, Lee, DM, Kaufman, RE, and Haynes, BF. "Structure and function of the CD7 molecule." Critical Reviews in Immunology 19, no. 4 (January 1999): 331-348. (Review)
  - Slentz-Kesler, KA, Hale, LP, and Kaufman, RE. "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms." Genomics 47, no. 3 (February 1, 1998): 327-340. Full Text Link to Item
  - Langdon, SD, and Kaufman, RE. "Gamma-globin gene promoter elements required for interaction with globin enhancers." Blood 91, no. 1 (January 1, 1998): 309-318. Link to Item
  - de Castro, CM, Rabe, SM, Langdon, SD, Fleenor, DE, Slentz-Kesler, K, Ahmed, MN, Qumsiyeh, MB, and Kaufman, RE. "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)." Genomics 42, no. 2 (June 1997): 227-235. Full Text
  - Ratech, H, Denning, S, and Kaufman, RE. "An analysis of alternatively spliced CD45 mRNA transcripts during T cell maturation in humans." Cell Immunol 177, no. 2 (May 1, 1997): 109-118. Full Text Link to Item
  - Fleenor, DE, Schanberg, LE, and Kaufman, RE. "A conserved element in the human CD7 promoter binds dbpA and a novel zinc finger protein." Blood 88, no. 10 (November 15, 1996): 770-770. Link to Item
  - Langdon, SD, and Kaufman, RE. "Gamma globin promoter elements required for interaction with globin enhancers." BLOOD 88, no. 10 (November 15, 1996): 595-595. Link to Item
  - SlentzKesler, K, and Kaufman, RE. "Characterization of K12, a novel molecule with potential growth promoting activity produced by granulocytes." BLOOD 88, no. 10 (November 15, 1996): 65-65. Link to Item
  - deCastro, CM, Rabe, SM, Langdon, SD, Fleenor, DE, and Kaufman, RE. "PE-2 (ERF), a novel ETS factor, is hypophosphorylated in c-kit(+) K562 cells." BLOOD 88, no. 10 (November 15, 1996): 3183-3183. Link to Item
  - Fleenor, DE, Langdon, SD, deCastro, CM, and Kaufman, RE. "Comparison of human and Xenopus GATA-2 promoters." Gene 179, no. 2 (November 14, 1996): 219-223. Link to Item
  - Lee, DM, Schanberg, LE, Fleenor, DE, Seldin, MF, Haynes, BF, and Kaufman, RE. "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters." Immunogenetics 44, no. 2 (January 1996): 108-114. Full Text
  - Sundv, JS, Barry, TS, Patel, DD, Allen, NB, Devlin, B, Bigner, S, Kaufman, RE, and Haynes, BF. "Myotropic Th1 T helper cell lymphoma presenting as granulomatous inflammatory masses in synovium and muscle." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
  - Vandenbark, GR, Chen, Y, Friday, E, Pavlik, K, Anthony, B, DeCastro, C, and Kaufman, RE. "Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements." Cell Growth and Differentiation 7, no. 10 (1996): 1383-1392.
  - deCastro, CM, Rabe, S, Langdon, SD, and Kaufman, RE. "Isolation and characterization of a novel ETS factor, PE-2." BLOOD 86, no. 10 (November 15, 1995): 2632-2632. Link to Item
  - Schanberg, LE, Lee, DM, Fleenor, DE, Ware, RE, Patel, DD, Haynes, BF, and Kaufman, RE. "Characterization of human CD7 transgenic mice." Journal of Immunology (Baltimore, Md. : 1950) 155, no. 5 (September 1995): 2407-2418.
  - LEE, DM, SELDIN, MF, KAUFMAN, RE, and HAYNES, BF. "GENETIC AND BIOCHEMICAL-CHARACTERIZATION OF MOUSE CD7 - IDENTIFICATION OF A NOVEL PROMOTER SEQUENCE." FASEB JOURNAL 9, no. 3 (March 9, 1995): A233-A233. Link to Item
  - Devlin, BH, Ratech, H, and Kaufman, R. "Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies." Diagn Mol Pathol 3, no. 4 (December 1994): 271-274. Link to Item
  - deCastro, CM, Denning, SM, Langdon, S, Vandenbark, GR, Kurtzberg, J, Scearce, R, Haynes, BF, and Kaufman, RE. "The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes." Exp Hematol 22, no. 10 (September 1994): 1025-1033. Link to Item
  - de Castro, CM, Devlin, B, Fleenor, DE, Lee, ME, and Kaufman, RE. "A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype." Blood 83, no. 4 (February 15, 1994): 1109-1116. Link to Item
  - DECASTRO, CM, DENNING, SM, LANGDON, S, KURTZBERG, J, SCEARCE, R, HAYNES, BF, and KAUFMAN, RE. "EXPRESSION OF C-KIT RECEPTORS AND KIT-LIGAND IN HUMAN THYMOCYTES AND THYMUS TISSUE." BLOOD 82, no. 10 (November 15, 1993): A244-A244. Link to Item
  - DECASTRO, CM, DEVLIN, B, FLEENOR, DE, LEE, M, and KAUFMAN, RE. "COMPUTER IMAGING OF BETA-DURHAM-NC [BETA(114) LEU-]PRO], A THALASSEMIC HEMOGLOBINOPATHY." BLOOD 82, no. 10 (November 15, 1993): A358-A358. Link to Item
  - RATECH, H, DENNING, S, and KAUFMAN, RE. "REGULATION OF ALTERNATIVELY SPLICED CD45 MESSENGER-RNA TRANSCRIPTS DURING T-CELL MATURATION." BLOOD 82, no. 10 (November 15, 1993): A244-A244. Link to Item
  - BOWEN, DT, PADUA, RA, BURNETT, AK, DECASTRO, CM, and KAUFMAN, RE. "2 NEW POLYMORPHISMS BUT NO MUTATIONS OF THE KIT GENE IN PATIENTS WITH MYELODYSPLASIA AT POSITIONS CORRESPONDING TO HUMAN FMS AND MURINE W LOCUS MUTATIONAL HOT-SPOTS." LEUKEMIA 7, no. 11 (November 1993): 1883-1885. Link to Item
  - Bentley, RC, Devlin, B, Kaufman, RE, Borowitz, M, and Ratech, H. "Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes." Hum Pathol 24, no. 6 (June 1993): 675-678. Link to Item
  - Fleenor, DE, and Kaufman, RE. "Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain." Blood 81, no. 10 (May 15, 1993): 2781-2790. Link to Item
  - FLEENOR, DE, and KAUFMAN, RE. "INSULATION OF THE BETA-GLOBIN GENE DOMAIN." CLINICAL RESEARCH 41, no. 2 (April 1993): A206-A206. Link to Item
  - GAUTIER, M, DECASTRO, C, LANGDON, S, OSTROWSKI, M, and KAUFMAN, RE. "REPROGRAMMING OF HEMIN INDUCED-DIFFERENTIATION BY ETS-LAC Z." CLINICAL RESEARCH 41, no. 2 (April 1993): A306-A306. Link to Item
  - Bowen, DT, Padua, RA, Burnett, AK, DeCastro, CM, and Kaufman, RE. "Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots." Leukemia 7, no. 11 (January 1, 1993): 1883-1885.
  - BARRY, TS, RENDT, KE, JONES, DM, WARE, RE, RICHTER, CB, MCCACHREN, SS, DEVLIN, B, KAUFMAN, RE, and HAYNES, BF. "ENGRAFTMENT OF HUMAN SYNOVIUM INTO SEVERE COMBINED IMMUNE DEFICIENT (SCID) MICE - MIGRATION OF HUMAN PERIPHERAL-BLOOD T-CELLS TO ENGRAFTED HUMAN SYNOVIUM." ARTHRITIS AND RHEUMATISM 35, no. 9 (September 1992): S45-S45. Link to Item
  - Petranka, JG, Fleenor, DE, Sykes, K, Kaufman, RE, and Rosse, WF. "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein." Proc Natl Acad Sci U S A 89, no. 17 (September 1, 1992): 7876-7879. Link to Item
  - Vandenbark, GR, deCastro, CM, Taylor, H, Dew-Knight, S, and Kaufman, RE. "Cloning and structural analysis of the human c-kit gene." Oncogene 7, no. 7 (July 1992): 1259-1266. Link to Item
  - KAUFMAN, RE. "HYDROXYUREA - SPECIFIC THERAPY FOR SICKLE-CELL-ANEMIA." BLOOD 79, no. 10 (May 15, 1992): 2503-2506. Link to Item
  - DECASTRO, CM, VANDENBARK, GR, and KAUFMAN, RE. "DETECTION OF THE KIT PROTOONCOGENE RECEPTOR ON HUMAN HEMATOPOIETIC PROGENITOR CELLS USING THE MONOCLONAL-ANTIBODY 9B9." EXPERIMENTAL HEMATOLOGY 20, no. 1 (January 1992): 111-111. Link to Item
  - Tyson, FL, Boyer, CM, Kaufman, R, O'Briant, K, Cram, G, Crews, JR, Soper, JT, Daly, L, Fowler, WC, and Haskill, JS. "Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines." American journal of obstetrics and gynecology 165, no. 3 (September 1991): 640-646. Full Text
  - Schanberg, LE, Fleenor, DE, Kurtzberg, J, Haynes, BF, and Kaufman, RE. "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene." Proceedings of the National Academy of Sciences of the United States of America 88, no. 2 (January 1991): 603-607. Full Text
  - Meadows, LM, George, DJ, and Kaufman, RE. "Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in α-interferon-treated cells." Journal of Biological Response Modifiers 9, no. 2 (1990): 212-220.
  - Sykes, K, and Kaufman, R. "A naturally occurring gamma globin gene mutation enhances SP1 binding activity." Molecular and cellular biology 10, no. 1 (January 1990): 95-102. Full Text
  - Meadows, LM, Rosse, WR, Moore, JO, Crawford, J, Laszlo, J, and Kaufman, RE. "Hodgkin's disease presenting as myelofibrosis." Cancer 64, no. 8 (October 1989): 1720-1726. Full Text
  - KINNEY, TR, SAWTSCHENKO, M, WHORTON, M, SHEARIN, J, STINE, C, HOFMAN, L, SAFKO, R, VITAGLIONE, T, and KAUFMAN, RE. "TECHNIQUES COMPARISON AND REPORT OF THE NORTH-CAROLINA EXPERIENCE." PEDIATRICS 83, no. 5 (May 1989): 843-848. Link to Item
  - Kinney, TR, Sawtschenko, M, Whorton, M, Shearin, J, Stine, C, Hofman, L, Safko, R, Vitaglione, T, and Kaufman, RE. "Newborn screening for sickle cell disease and other hemoglobinopathies. Techniques' comparison and report of the North Carolina experience." Pediatrics 83, no. 5 Pt 2 (May 1989): 843-848. Link to Item
  - KAUFMAN, RE. "CHARACTERIZATION OF AN ERYTHROID DNASE-I SUPERSENSITIVE SITE." CLINICAL RESEARCH 37, no. 2 (April 1989): A374-A374. Link to Item
  - Stine, C, Hofman, L, Safko, R, Vitaglione, T, and Kaufman, RE. "Techniques' comparison and report of the North Carolina experience." Pediatrics 83, no. 5 SUPPL. (January 1, 1989): 843-848.
  - Sykes, K, and Kaufman, R. "A human gamma globin gene variant binds SP1." Progress in clinical and biological research 316A (January 1989): 237-246.
  - Phillips, G, Hartman, J, Kinney, TR, Sokal, JE, and Kaufman, RE. "Chronic granulocytic leukemia in a patient with sickle cell anemia." Am J Med 85, no. 4 (October 1988): 567-569. Link to Item
  - Ortel, TL, Onorato, JJ, Bedrosian, CL, and Kaufman, RE. "Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome." Am J Hematol 29, no. 1 (September 1988): 44-48. Link to Item
  - Markert, ML, Hutton, JJ, Wiginton, DA, States, JC, and Kaufman, RE. "Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements." The Journal of Clinical Investigation 81, no. 5 (May 1988): 1323-1327. Full Text
  - Geesin, JC, Darr, D, Kaufman, R, Murad, S, and Pinnell, SR. "Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast." The Journal of investigative dermatology 90, no. 4 (April 1988): 420-424. Full Text
  - TAJIMA, S, PHILLIPS, C, MURAD, S, KAUFMAN, R, and PINNELL, S. "TRANSCRIPTIONAL REGULATION OF PROCOLLAGEN SYNTHESIS BY ASCORBIC-ACID." CLINICAL RESEARCH 36, no. 3 (April 1988): A697-A697. Link to Item
  - TAJIMA, S, PHILLIPS, C, MURAD, S, KAUFMAN, R, and PINNELL, S. "TRANSCRIPTIONAL REGULATION OF PROCOLLAGEN SYNTHESIS BY ASCORBIC-ACID." JOURNAL OF INVESTIGATIVE DERMATOLOGY 90, no. 4 (April 1988): 611-611. Link to Item
  - KAUFMAN, RE, STINNETT, S, and PHILLIPS, G. "A MUTATION AT POSITION-158 OF THE G-GAMMA GLOBIN GENE IS LINKED TO BETA-THALASSEMIA INTERMEDIA." CLINICAL RESEARCH 36, no. 1 (January 1988): A16-A16. Link to Item
  - DICKEY, LF, SREEDHARAN, S, THEIL, EC, DIDSBURY, JR, WANG, YH, and KAUFMAN, RE. "DIFFERENCES IN THE REGULATION OF MESSENGER-RNA FOR HOUSEKEEPING AND SPECIALIZED-CELL FERRITIN - A COMPARISON OF 3 DISTINCT FERRITIN COMPLEMENTARY DNAS, THE CORRESPONDING SUBUNITS, AND IDENTIFICATION OF THE 1ST PROCESSED PSEUDOGENE IN AMPHIBIA." JOURNAL OF BIOLOGICAL CHEMISTRY 262, no. 16 (June 5, 1987): 7901-7907. Link to Item
  - Markert, ML, Hershfield, MS, Wiginton, DA, States, JC, Ward, FE, Bigner, SH, Buckley, RH, Kaufman, RE, and Hutton, JJ. "Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency." J Immunol 138, no. 10 (May 15, 1987): 3203-3206. Link to Item
  - KAUFMAN, RE. "CHARACTERIZATION OF FETAL-TYPE ACETYLCHOLINESTERASE IN HEMIN-TREATED K562 CELL-CULTURE - COMMENTARY." BLOOD CELLS 12, no. 3 (1987): 653-655. Link to Item
  - Introna, M, Hamilton, TA, Kaufman, RE, Adams, DO, and Bast, RC. "Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes." Journal of Immunology (Baltimore, Md. : 1950) 137, no. 8 (October 1986): 2711-2715.
  - McCachren, SS, Nichols, J, Kaufman, RE, and Niedel, JE. "Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation." Blood 68, no. 2 (August 1986): 412-416.
  - SREEDHARAN, SP, DIDSBURY, JR, THEIL, EC, MCKENZIE, AR, and KAUFMAN, RE. "CHARACTERIZATION OF A TADPOLE (RANA-CATESBEIANA) RED-CELL FERRITIN L-SUBUNIT MESSENGER-RNA." FEDERATION PROCEEDINGS 45, no. 6 (May 1986): 1699-1699. Link to Item
  - WANG, YH, DIDSBURY, JR, DICKEY, L, THEIL, EC, and KAUFMAN, RE. "3 DIFFERENT CDNAS CODING FOR EMBRYONIC BETA-GLOBIN OF THE BULLFROG, RANA-CATESBEIANA." FEDERATION PROCEEDINGS 45, no. 6 (May 1986): 1698-1698. Link to Item
  - DIDSBURY, JR, THEIL, EC, KAUFMAN, RE, and DICKEY, LF. "MULTIPLE RED-CELL FERRITIN MESSENGER-RNAS, WHICH CODE FOR AN ABUNDANT PROTEIN IN THE EMBRYONIC-CELL TYPE, ANALYZED BY CDNA SEQUENCE AND BY PRIMER EXTENSION OF THE 5'-UNTRANSLATED REGIONS." JOURNAL OF BIOLOGICAL CHEMISTRY 261, no. 2 (January 15, 1986): 949-955. Link to Item
  - Williams, RS, Salmons, S, Newsholme, EA, Kaufman, RE, and Mellor, J. "Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle." J Biol Chem 261, no. 1 (January 5, 1986): 376-380. Link to Item
  - INTRONA, M, HAMILTON, TA, KAUFMAN, RE, STRASSMAN, G, ADAMS, DO, and BAST, RC. "FUNCTIONAL ACTIVATION OF MURINE PERITONEAL-MACROPHAGES WITH BACTERIAL LIPOPOLYSACCHARIDE ALTERS EXPRESSION OF C-FOS AND C-MYC ONCOGENES." JOURNAL OF CELLULAR BIOCHEMISTRY (1986): 21-21. Link to Item
  - KAUFMAN, RE. "PROTOONCOGENES AS REGULATORS OF GROWTH AND DIFFERENTIATION." JOURNAL OF NEURO-ONCOLOGY 4, no. 1 (1986): 92-92. Link to Item
  - Atweh, GF, Anagnou, NP, Shearin, J, Forget, BG, and Kaufman, RE. "β-thalassemia resulting from a single nucleotide substitution in an acceptor splice site." Nucleic Acids Research 13, no. 3 (February 11, 1985): 777-790. Full Text
  - ATWEH, GF, ANAGNOU, NP, SHEARIN, J, FORGET, BG, and KAUFMAN, RE. "BETA-THALASSEMIA RESULTING FROM A SINGLE NUCLEOTIDE SUBSTITUTION IN AN ACCEPTOR SPLICE SITE." NUCLEIC ACIDS RESEARCH 13, no. 3 (1985): 777-790. Full Text Link to Item
  - GROBLERRABIE, AF, BREBNER, DK, VANDENPLAS, S, WALLIS, G, DALGLEISH, R, KAUFMAN, RE, BESTER, AJ, MATHEW, CGP, and BOYD, CD. "POLYMORPHISM OF DNA-SEQUENCE IN THE HUMAN PRO ALPHA-2(I) COLLAGEN GENE." JOURNAL OF MEDICAL GENETICS 22, no. 3 (1985): 182-186. Full Text Link to Item
  - Henke, E, Leader, M, Tajima, S, Pinnell, S, and Kaufman, R. "A 38 base pair insertion in the proα2(I) collagen gene of a patient with Marfan syndrome." Journal of Cellular Biochemistry 27, no. 2 (1985): 169-174. Full Text
  - KAUFMAN, R, HENKE, E, DUVIC, M, BISAT, F, and PINNELL, S. "Normal and Mutant Human Collagen Genes." Annals of the New York Academy of Sciences 460, no. 1 (January 1, 1985): 461-462. Full Text
  - Lobach, DF, Bolognesi, DP, and Kaufman, RE. "Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus." Cancer Invest 3, no. 2 (1985): 145-160. (Review) Link to Item
  - Tajima, S, Ting, JP, Pinnell, SR, and Kaufman, RE. "Isolation and characterization of a human pro alpha 2(I) collagen gene segment." J Invest Dermatol 82, no. 3 (March 1984): 265-269. Link to Item
  - DUVIC, M, PINNELL, S, and KAUFMAN, R. "LOCALIZATION OF THE 5' END OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE." CLINICAL RESEARCH 32, no. 2 (1984): A580-A580. Link to Item
  - DUVIC, M, PINNELL, S, and KAUFMAN, R. "LOCALIZATION OF THE 5' END OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE." JOURNAL OF INVESTIGATIVE DERMATOLOGY 82, no. 4 (1984): 440-440. Link to Item
  - HENKE, E, PINNELL, S, and KAUFMAN, R. "A 38 BASE PAIR INSERTION IN THE PRO-ALPHA-2(I) COLLAGEN GENE OF A PATIENT WITH MARFAN-SYNDROME." CLINICAL RESEARCH 32, no. 2 (1984): A492-A492. Link to Item
  - NICHOLS, J, CHUA, C, and KAUFMAN, R. "CLASSES OF AMPLIFIED C-MYC GENES IN HL60." CLINICAL RESEARCH 32, no. 2 (1984): A420-A420. Link to Item
  - ATWEH, GF, SANE, D, and KAUFMAN, RE. "CHARACTERIZATION OF THE DELETION IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN." CLINICAL RESEARCH 31, no. 2 (1983): A308-A308. Link to Item
  - DUVIC, M, PINNELL, S, and KAUFMAN, R. "LOCALIZATION OF THE 5' AND OF HUMAN PRO-ALPHA-2(I) COLLAGEN GENE." CLINICAL RESEARCH 31, no. 5 (1983): A834-A834. Link to Item
  - DUVIC, M, TING, J, TAJIMA, S, KAUFMAN, R, and PINNELL, S. "CHARACTERIZATION OF THE HUMAN-ALPHA-(I) COLLAGEN GENE." CLINICAL RESEARCH 31, no. 2 (1983): A563-A563. Link to Item
  - DUVIC, M, TING, J, TAJIMA, S, KAUFMAN, R, and PINNELL, S. "CHARACTERIZATION OF THE HUMAN ALPHA-2(I) COLLAGEN GENE." JOURNAL OF INVESTIGATIVE DERMATOLOGY 80, no. 4 (1983): 303-303. Link to Item
  - RILEY, E, TAJIMA, S, KAUFMAN, R, and PINNELL, S. "RESTRICTION ENZYME MAPPING OF THE PRO ALPHA-2 (I) GENE IN A PATIENT WITH THE MARFAN-SYNDROME." CLINICAL RESEARCH 31, no. 2 (1983): A598-A598. Link to Item
  - RILEY, E, TAJIMA, S, KAUFMAN, R, and PINNELL, S. "RESTRICTION ENZYME MAPPING OF THE PRO-ALPHA2-(I) GENE IN A PATIENT WITH THE MARFAN-SYNDROME." JOURNAL OF INVESTIGATIVE DERMATOLOGY 80, no. 4 (1983): 314-314. Link to Item
  - KAUFMAN, RE. "CHARACTERIZATION OF THE 3' END OF THE DELETION IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN (HPFH)." CLINICAL RESEARCH 30, no. 2 (1982): A320-A320. Link to Item
  - TAJIMA, S, KAUFMAN, RE, and PINNELL, SR. "ISOLATION AND PARTIAL CHARACTERIZATION OF HUMAN GENOMIC DNA FOR THE PRO ALPHA-2 (I) COLLAGEN CHAIN." CLINICAL RESEARCH 30, no. 2 (1982): A611-A611. Link to Item
  - TAJIMA, S, KAUFMAN, RE, and PINNELL, SR. "ISOLATION AND PARTIAL CHARACTERIZATION OF HUMAN GENOMIC DNA FOR THE PRO ALPHA-2 (I) COLLAGEN CHAIN." JOURNAL OF INVESTIGATIVE DERMATOLOGY 78, no. 4 (1982): 344-345. Link to Item
- Conference Papers
  - Laughlin, MJ, McKinnon, K, Demarest, J, Koropchak, CM, Weinhold, K, Lyerly, HK, Gilboa, E, Kaufman, R, DeSombre, K, Iacobucci, M, Adams, D, Cook, JM, Martinek, L, DeOliveira, D, and Kurtzberg, J. "Generation of autologous CD4+ T lymphocyte clones specific for precursor-B (pre-B) lymphoblasts via dendritic cell (DC) presentation." November 15, 1997. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers