Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program.
Journal Article (Journal Article)
Ganetespib, an Hsp90 inhibitor, was tested against the PPTP in vitro cell line panel and selected xenografts in vivo, including JAK2- and BRAF-mutated models. Ganetespib demonstrated potent in vitro cytotoxic activity (median rIC50 8.8 nM, range 4.4-27.1 nM). In vivo, ganetespib induced significant differences in EFS distribution for 4 of 11 xenografts. Intermediate activity (EFS T/C > 2) was noted only for the MV4;11 xenograft, and there were no objective responses. Administered as single agents, Hsp90 inhibitors examined by the PPTP have shown limited evidence for a therapeutic window against both solid tumor and leukemia pediatric preclinical models.
Full Text
Duke Authors
Cited Authors
- Lock, RB; Carol, H; Maris, JM; Kang, MH; Reynolds, CP; Kolb, EA; Gorlick, R; Keir, ST; Billups, CA; Kurmasheva, RT; Houghton, PJ; Smith, MA
Published Date
- July 2013
Published In
Volume / Issue
- 60 / 7
Start / End Page
- E42 - E45
PubMed ID
- 23303741
Pubmed Central ID
- PMC4225043
Electronic International Standard Serial Number (EISSN)
- 1545-5017
Digital Object Identifier (DOI)
- 10.1002/pbc.24451
Language
- eng
Conference Location
- United States