Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program.

Journal Article (Journal Article)

Ganetespib, an Hsp90 inhibitor, was tested against the PPTP in vitro cell line panel and selected xenografts in vivo, including JAK2- and BRAF-mutated models. Ganetespib demonstrated potent in vitro cytotoxic activity (median rIC50 8.8 nM, range 4.4-27.1 nM). In vivo, ganetespib induced significant differences in EFS distribution for 4 of 11 xenografts. Intermediate activity (EFS T/C > 2) was noted only for the MV4;11 xenograft, and there were no objective responses. Administered as single agents, Hsp90 inhibitors examined by the PPTP have shown limited evidence for a therapeutic window against both solid tumor and leukemia pediatric preclinical models.

Full Text

Duke Authors

Cited Authors

  • Lock, RB; Carol, H; Maris, JM; Kang, MH; Reynolds, CP; Kolb, EA; Gorlick, R; Keir, ST; Billups, CA; Kurmasheva, RT; Houghton, PJ; Smith, MA

Published Date

  • July 2013

Published In

Volume / Issue

  • 60 / 7

Start / End Page

  • E42 - E45

PubMed ID

  • 23303741

Pubmed Central ID

  • PMC4225043

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.24451

Language

  • eng

Conference Location

  • United States