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Stephen Thomas Keir

Professor in Neurosurgery
Neurosurgery, Neuro-Oncology
Box 3624 Med Ctr, Durham, NC 27710
231 Baker House, Durham, NC 27710

Overview


Brain Tumors, Preclinical Testing, Translational Research

Current Appointments & Affiliations


Professor in Neurosurgery · 2021 - Present Neurosurgery, Neuro-Oncology, Neurosurgery
Member of the Duke Cancer Institute · 1992 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics.

Conference Nat Genet · May 2025 The evolution of isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) after standard-of-care therapy remains poorly understood. Here we analyzed matched primary and recurrent GBMs from 59 patients using single-nucleus RNA sequencing and bulk DNA sequ ... Full text Link to item Cite

The multilayered transcriptional architecture of glioblastoma ecosystems.

Journal Article Nat Genet · May 2025 In isocitrate dehydrogenase wildtype glioblastoma (GBM), cellular heterogeneity across and within tumors may drive therapeutic resistance. Here we analyzed 121 primary and recurrent GBM samples from 59 patients using single-nucleus RNA sequencing and bulk ... Full text Link to item Cite

The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy.

Journal Article Cancer Immunol Res · June 4, 2024 Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame peptides (NOP) expressed in tumo ... Full text Link to item Cite
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Recent Grants


ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027

PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME

ResearchInvestigator · Awarded by Jewish Communal Fund · 2022 - 2026

Evaluation of Cannabinoid Therapeutics in Brain Tumor Xenografts

ResearchPrincipal Investigator · Awarded by Diverse Biotech · 2024 - 2025

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Education, Training & Certifications


Duke University · 2019 M.M.C.i.
University of North Carolina, Chapel Hill · 2004 DrPH
University of North Carolina, Chapel Hill · 2001 M.P.H.