Overview
Brain Tumors, Preclinical Testing, Translational Research
Current Appointments & Affiliations
Professor in Neurosurgery
·
2021 - Present
Neurosurgery, Neuro-Oncology,
Neurosurgery
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics.
Conference Nat Genet · May 2025 The evolution of isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) after standard-of-care therapy remains poorly understood. Here we analyzed matched primary and recurrent GBMs from 59 patients using single-nucleus RNA sequencing and bulk DNA sequ ... Full text Link to item CiteThe multilayered transcriptional architecture of glioblastoma ecosystems.
Journal Article Nat Genet · May 2025 In isocitrate dehydrogenase wildtype glioblastoma (GBM), cellular heterogeneity across and within tumors may drive therapeutic resistance. Here we analyzed 121 primary and recurrent GBM samples from 59 patients using single-nucleus RNA sequencing and bulk ... Full text Link to item CiteThe Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy.
Journal Article Cancer Immunol Res · June 4, 2024 Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame peptides (NOP) expressed in tumo ... Full text Link to item CiteRecent Grants
ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchInvestigator · Awarded by Jewish Communal Fund · 2022 - 2026Evaluation of Cannabinoid Therapeutics in Brain Tumor Xenografts
ResearchPrincipal Investigator · Awarded by Diverse Biotech · 2024 - 2025View All Grants
Education, Training & Certifications
Duke University ·
2019
M.M.C.i.
University of North Carolina, Chapel Hill ·
2004
DrPH
University of North Carolina, Chapel Hill ·
2001
M.P.H.