Overview
Brain Tumors, Preclinical Testing, Translational Research
Current Appointments & Affiliations
Professor in Neurosurgery
·
2021 - Present
Neurosurgery, Neuro-Oncology,
Neurosurgery
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy.
Journal Article Cancer Immunol Res · June 4, 2024 Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame peptides (NOP) expressed in tumo ... Full text Link to item CiteInterplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Journal Article Nat Commun · January 25, 2024 Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. ... Full text Link to item CiteA neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma.
Journal Article Neurooncol Adv · 2024 BACKGROUND: A major hurdle to effectively treating glioblastoma (GBM) patients is the lack of longitudinal information about tumor progression, evolution, and treatment response. METHODS: In this study, we report the use of a neural tract-inspired conduit ... Full text Link to item CiteRecent Grants
ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchInvestigator · Awarded by Jewish Communal Fund · 2022 - 2026Evaluation of Cannabinoid Therapeutics in Brain Tumor Xenografts
ResearchPrincipal Investigator · Awarded by Diverse Biotech · 2024 - 2025View All Grants
Education, Training & Certifications
Duke University ·
2019
M.M.C.i.
University of North Carolina, Chapel Hill ·
2004
DrPH
University of North Carolina, Chapel Hill ·
2001
M.P.H.