Overview
Brain Tumors, Preclinical Testing, Translational Research
Current Duke Appointments & Affiliations
Professor in Neurosurgery
·
2021 - Present
Neurosurgery, Neuro-Oncology,
Neurosurgery
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres.
Journal article Neuro Oncol · April 1, 2026 BACKGROUND: Approximately 10% of cancers achieve replicative immortality through a telomerase-independent mechanism of telomere maintenance, termed Alternative Lengthening of Telomeres (ALT). ALT is particularly prevalent in certain subtypes of malignant g ... Full text Link to item CiteA surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.
Journal article Sci Rep · October 23, 2025 Many cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma. Evolocumab is a clinically approved PCSK9 in ... Full text Open Access Link to item CiteRepurposing the DNA Labeling Agent EdU for Therapy against Heterogeneous Patient Glioblastoma.
Journal article Mol Cancer Ther · August 1, 2025 Glioblastoma (GBM) is the most common type of malignant central nervous system tumor, and more than 300,000 people are diagnosed with GBM worldwide annually. Based on its recognition as damage by nucleotide excision repair, we now repurpose the DNA labelin ... Full text Link to item CiteRecent Grants
McCain/Bayh Glioblastoma Consortium
Clinical TrialProgram Manager · Awarded by Department of Defense · 2025 - 2029ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2025 - 2028PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchInvestigator · Awarded by Jewish Communal Fund · 2022 - 2027View All Grants
Education
Duke University ·
2019
M.M.C.i.
University of North Carolina, Chapel Hill ·
2004
DrPH
University of North Carolina, Chapel Hill ·
2001
M.P.H.