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Newborn screening for severe combined immunodeficiency (SCID): a review.

Publication ,  Journal Article
Huang, H; Manton, KG
Published in: Frontiers in bioscience : a journal and virtual library
May 2005

Because prompt intervention may prevent complications, early diagnosis is important in many inherited metabolic diseases. Early diagnosis of Severe Combined Immunodeficiency (SCID) is critical - because chances for successful treatment are highest for infants who have not yet experienced severe opportunistic infections. SCID is a rare disease that can be detected in newborn infants (i.e., those more or equal 1 month of age) by automated blood count and manual differential. Early diagnosis of SCID is rare since, because estimates of the incidence rate range from one in 50,000 to 100,000 births, most pediatricians do not routinely count white blood cells in newborns. Tests for T-cell lymphopenia (TCLP) using dried blood spots (DBS) could be used to identify children with SCID - as well as for other immunodeficiencies that would not be apparent until after the child developed an infection. Screening newborns for SCID would allow early diagnosis and treatment -- as well as genetic counseling for the family.

Duke Scholars

Published In

Frontiers in bioscience : a journal and virtual library

DOI

ISSN

1093-9946

Publication Date

May 2005

Volume

10

Start / End Page

1024 / 1039

Related Subject Headings

  • Severe Combined Immunodeficiency
  • Mass Screening
  • Infant, Newborn
  • Humans
  • Genetic Diseases, Inborn
  • Genetic Counseling
  • Feasibility Studies
  • Biochemistry & Molecular Biology
  • 1116 Medical Physiology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, H., & Manton, K. G. (2005). Newborn screening for severe combined immunodeficiency (SCID): a review. Frontiers in Bioscience : A Journal and Virtual Library, 10, 1024–1039. https://doi.org/10.2741/1596
Huang, Hai, and Kenneth G. Manton. “Newborn screening for severe combined immunodeficiency (SCID): a review.Frontiers in Bioscience : A Journal and Virtual Library 10 (May 2005): 1024–39. https://doi.org/10.2741/1596.
Huang H, Manton KG. Newborn screening for severe combined immunodeficiency (SCID): a review. Frontiers in bioscience : a journal and virtual library. 2005 May;10:1024–39.
Huang, Hai, and Kenneth G. Manton. “Newborn screening for severe combined immunodeficiency (SCID): a review.Frontiers in Bioscience : A Journal and Virtual Library, vol. 10, May 2005, pp. 1024–39. Epmc, doi:10.2741/1596.
Huang H, Manton KG. Newborn screening for severe combined immunodeficiency (SCID): a review. Frontiers in bioscience : a journal and virtual library. 2005 May;10:1024–1039.

Published In

Frontiers in bioscience : a journal and virtual library

DOI

ISSN

1093-9946

Publication Date

May 2005

Volume

10

Start / End Page

1024 / 1039

Related Subject Headings

  • Severe Combined Immunodeficiency
  • Mass Screening
  • Infant, Newborn
  • Humans
  • Genetic Diseases, Inborn
  • Genetic Counseling
  • Feasibility Studies
  • Biochemistry & Molecular Biology
  • 1116 Medical Physiology
  • 1112 Oncology and Carcinogenesis