The role of oxidative damage in mitochondria during aging: a review.


Journal Article (Review)

Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron transport chain plays an important role in energy production and is a significant source of ROS that damage DNA, RNA, and proteins in cells. While oxidative events in other cell organelles are likely to contribute to the pathobiology of aging, this review highlights alterations in mitochondrial function that, due to accumulated oxidative damage, occur with age.

Full Text

Duke Authors

Cited Authors

  • Huang, H; Manton, KG

Published Date

  • May 2004

Published In

Volume / Issue

  • 9 /

Start / End Page

  • 1100 - 1117

PubMed ID

  • 14977532

Pubmed Central ID

  • 14977532

International Standard Serial Number (ISSN)

  • 1093-9946

Digital Object Identifier (DOI)

  • 10.2741/1298


  • eng