Dynamic paradigms for human mortality and aging.

Published

Journal Article

Hazard models are often applied to mortality data of humans and other species so that the parameter estimates made for those models can be used to make inferences about the biology, and comparative biology, of aging processes. Enough longitudinal data on physiological and functional changes in humans now exist to know that the age trajectory of the physiological state of individuals is multidimensional, stochastic, and plastic. Thus, to fully assess the biological significance of existing longitudinal data on human aging and mortality processes, multivariate stochastic process models must be developed that are biologically detailed and valid. This requires assessing genetic mechanisms controlling human longevity and rates of aging, developing models of how those traits may have evolved, and developing statistical methods for identifying gene environment interactions. This article examines the theoretical basis for such models and the biological rationale of their parametric structure. Several examples are given.

Full Text

Duke Authors

Cited Authors

  • Manton, KG

Published Date

  • June 1999

Published In

Volume / Issue

  • 54 / 6

Start / End Page

  • B247 - B254

PubMed ID

  • 10411010

Pubmed Central ID

  • 10411010

Electronic International Standard Serial Number (EISSN)

  • 1758-535X

International Standard Serial Number (ISSN)

  • 1079-5006

Digital Object Identifier (DOI)

  • 10.1093/gerona/54.6.b247

Language

  • eng