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Atomic force microscopy captures folded ribosome bound nascent chains.

Publication ,  Journal Article
Loksztejn, A; Scholl, Z; Marszalek, PE
Published in: Chemical communications (Cambridge, England)
December 2012

Direct visualization of co-translational folding of nascent polypeptide chains is challenging. Here we present, for the first time, AFM images of large protein constructs based on the membrane binding domain of ankyrin-R, complexed with the ribosome. The characteristic "horse-shoe" shape of ankyrin-R emerging from the ribosome was captured.

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Published In

Chemical communications (Cambridge, England)

DOI

EISSN

1364-548X

ISSN

1359-7345

Publication Date

December 2012

Volume

48

Issue

96

Start / End Page

11727 / 11729

Related Subject Headings

  • Ribosomes
  • Protein Structure, Tertiary
  • Protein Folding
  • Protein Conformation
  • Protein Biosynthesis
  • Protein Binding
  • Peptides
  • Organic Chemistry
  • Models, Molecular
  • Microscopy, Atomic Force
 

Citation

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Loksztejn, A., Scholl, Z., & Marszalek, P. E. (2012). Atomic force microscopy captures folded ribosome bound nascent chains. Chemical Communications (Cambridge, England), 48(96), 11727–11729. https://doi.org/10.1039/c2cc35551e
Loksztejn, Anna, Zackary Scholl, and Piotr E. Marszalek. “Atomic force microscopy captures folded ribosome bound nascent chains.Chemical Communications (Cambridge, England) 48, no. 96 (December 2012): 11727–29. https://doi.org/10.1039/c2cc35551e.
Loksztejn A, Scholl Z, Marszalek PE. Atomic force microscopy captures folded ribosome bound nascent chains. Chemical communications (Cambridge, England). 2012 Dec;48(96):11727–9.
Loksztejn, Anna, et al. “Atomic force microscopy captures folded ribosome bound nascent chains.Chemical Communications (Cambridge, England), vol. 48, no. 96, Dec. 2012, pp. 11727–29. Epmc, doi:10.1039/c2cc35551e.
Loksztejn A, Scholl Z, Marszalek PE. Atomic force microscopy captures folded ribosome bound nascent chains. Chemical communications (Cambridge, England). 2012 Dec;48(96):11727–11729.
Journal cover image

Published In

Chemical communications (Cambridge, England)

DOI

EISSN

1364-548X

ISSN

1359-7345

Publication Date

December 2012

Volume

48

Issue

96

Start / End Page

11727 / 11729

Related Subject Headings

  • Ribosomes
  • Protein Structure, Tertiary
  • Protein Folding
  • Protein Conformation
  • Protein Biosynthesis
  • Protein Binding
  • Peptides
  • Organic Chemistry
  • Models, Molecular
  • Microscopy, Atomic Force