Chapter 6: assessing applicability of medical test studies in systematic reviews.

Journal Article (Journal Article)

Use of medical tests should be guided by research evidence about the accuracy and utility of those tests in clinical care settings. Systematic reviews of the literature about medical tests must address applicability to real-world decision-making. Challenges for reviews include: (1) lack of clarity in key questions about the intended applicability of the review, (2) numerous studies in many populations and settings, (3) publications that provide too little information to assess applicability, (4) secular trends in prevalence and the spectrum of the condition for which the test is done, and (5) changes in the technology of the test itself. We describe principles for crafting reviews that meet these challenges and capture the key elements from the literature necessary to understand applicability.

Full Text

Duke Authors

Cited Authors

  • Hartmann, KE; Matchar, DB; Chang, S

Published Date

  • June 2012

Published In

Volume / Issue

  • 27 Suppl 1 / Suppl 1

Start / End Page

  • S39 - S46

PubMed ID

  • 22648674

Pubmed Central ID

  • PMC3364357

Electronic International Standard Serial Number (EISSN)

  • 1525-1497

Digital Object Identifier (DOI)

  • 10.1007/s11606-011-1961-9


  • eng

Conference Location

  • United States