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David Bruce Matchar

Professor of Medicine
Medicine, General Internal Medicine
Box 102811, DUMC, Durham, NC 27705
Erwin Terrace II, Box 16, Durham, NC 27710


My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Key Words: clinical policy, disease management, stroke, decision analysis, clinical guidelines

Current Appointments & Affiliations

Professor of Medicine · 1999 - Present Medicine, General Internal Medicine, Medicine
Director of the Center for Clinical Health Policy Research · 1988 - Present Institutes and Centers, School of Medicine
Professor of Pathology · 2009 - Present Pathology, Clinical Science Departments
Affiliate, Duke Global Health Institute · 2009 - Present Duke Global Health Institute, University Institutes and Centers

Education, Training & Certifications

University of Maryland, College Park · 1980 M.D.