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David Bruce Matchar

Professor of Medicine
Medicine, General Internal Medicine
Box 102811, DUMC, Durham, NC 27705
Erwin Terrace II, Box 16, Durham, NC 27710

Overview


My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Key Words: clinical policy, disease management, stroke, decision analysis, clinical guidelines

Current Appointments & Affiliations


Professor of Medicine · 1999 - Present Medicine, General Internal Medicine, Medicine
Director of the Center for Clinical Health Policy Research · 1988 - Present Institutes and Centers, School of Medicine
Professor of Pathology · 2009 - Present Pathology, Clinical Science Departments
Affiliate, Duke Global Health Institute · 2009 - Present Duke Global Health Institute, University Institutes and Centers

In the News


Published January 12, 2016
Study: Mental health of stroke survivors and their family caregivers interrelated

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Recent Publications


Development and validation of a brief assessment of normative health and health-related social needs using the Simple Segmentation Tool.

Journal Article BMC Health Serv Res · February 11, 2025 OBJECTIVES: Population segmentation provides a promising solution to address patients' complex needs to provide "whole person" care. The primary objective of this study is to create an expert-based algorithm based on combinations of medical and social char ... Full text Link to item Cite

A co-designed conceptual model for implementing falls prevention programmes for community-dwelling older adults in Singapore: a systems thinking approach.

Journal Article Age Ageing · February 2, 2025 INTRODUCTION: Implementing falls prevention programmes in the community presents numerous challenges. We sought to understand the dynamics between the determinants influencing implementation to develop a common conceptual model describing the complexities ... Full text Link to item Cite

Clinical Implementation of Nephrologist-Led Genomic Testing for Glomerular Diseases in Singapore: Rationale and Protocol.

Journal Article Am J Nephrol · 2025 INTRODUCTION: The early diagnosis and appropriate treatment of monogenic glomerular diseases can reduce kidney failure, avoid unnecessary investigations such as kidney biopsies and ineffective treatment with immunosuppressants, guide transplant decisions, ... Full text Link to item Cite
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Recent Grants


Expanding Quality Care for Glaucoma through a Provider-Patient Partnership

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2013

Thrombosis and Hemostasis Centers Research and Prevention Network

ResearchConsultant · Awarded by Centers for Disease Control and Prevention · 2002 - 2013

EPC Project: Medical Test Guides - training modules

ResearchCo Investigator · Awarded by Agency for Healthcare Research and Quality · 2011 - 2012

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Education, Training & Certifications


University of Maryland, College Park · 1980 M.D.