Emerging insights into the genesis of epilepsy.

Journal Article (Journal Article;Review)

Epilepsies are a diverse collection of brain disorders that affect 1-2% of the population. Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in only a subset of affected individuals, and are often accompanied by persistent toxic effects. It is hoped that insight into the cellular and molecular mechanisms of epileptogenesis will lead to new therapies, prevention, or even a cure. Emerging insights point to alterations of synaptic function and intrinsic properties of neurons as common mechanisms underlying the hyperexcitability in diverse forms of epilepsy.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO

Published Date

  • June 24, 1999

Published In

Volume / Issue

  • 399 / 6738 Suppl

Start / End Page

  • A15 - A22

PubMed ID

  • 10392576

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/399a015


  • eng

Conference Location

  • England