Emerging insights into the genesis of epilepsy.
Journal Article (Journal Article;Review)
Epilepsies are a diverse collection of brain disorders that affect 1-2% of the population. Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in only a subset of affected individuals, and are often accompanied by persistent toxic effects. It is hoped that insight into the cellular and molecular mechanisms of epileptogenesis will lead to new therapies, prevention, or even a cure. Emerging insights point to alterations of synaptic function and intrinsic properties of neurons as common mechanisms underlying the hyperexcitability in diverse forms of epilepsy.
Full Text
Duke Authors
Cited Authors
- McNamara, JO
Published Date
- June 24, 1999
Published In
Volume / Issue
- 399 / 6738 Suppl
Start / End Page
- A15 - A22
PubMed ID
- 10392576
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/399a015
Language
- eng
Conference Location
- England