Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.
Publication
, Journal Article
Geesin, JC; Darr, D; Kaufman, R; Murad, S; Pinnell, SR
Published in: J Invest Dermatol
April 1988
In cultured human skin fibroblasts, ascorbic acid stimulates collagen production with no apparent change in the intracellular degradation of newly synthesized procollagen. To understand the basis for this effect, we measured the steady-state levels of type I and type III procollagen mRNAs in cells treated with ascorbic acid. A three- to fourfold increase in collagen synthesis was associated with a two- to threefold increase in the levels of mRNAs for both type I and type III procollagens. These effects of ascorbic acid are explained by a translational control linked either to procollagen gene transcription or mRNA degradation.
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Published In
J Invest Dermatol
DOI
ISSN
0022-202X
Publication Date
April 1988
Volume
90
Issue
4
Start / End Page
420 / 424
Location
United States
Related Subject Headings
- Skin
- RNA, Messenger
- Procollagen
- Male
- Humans
- Fibroblasts
- Dermatology & Venereal Diseases
- DNA
- Collagen
- Ascorbic Acid
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Geesin, J. C., Darr, D., Kaufman, R., Murad, S., & Pinnell, S. R. (1988). Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol, 90(4), 420–424. https://doi.org/10.1111/1523-1747.ep12460849
Geesin, J. C., D. Darr, R. Kaufman, S. Murad, and S. R. Pinnell. “Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.” J Invest Dermatol 90, no. 4 (April 1988): 420–24. https://doi.org/10.1111/1523-1747.ep12460849.
Geesin JC, Darr D, Kaufman R, Murad S, Pinnell SR. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol. 1988 Apr;90(4):420–4.
Geesin, J. C., et al. “Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.” J Invest Dermatol, vol. 90, no. 4, Apr. 1988, pp. 420–24. Pubmed, doi:10.1111/1523-1747.ep12460849.
Geesin JC, Darr D, Kaufman R, Murad S, Pinnell SR. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol. 1988 Apr;90(4):420–424.
Published In
J Invest Dermatol
DOI
ISSN
0022-202X
Publication Date
April 1988
Volume
90
Issue
4
Start / End Page
420 / 424
Location
United States
Related Subject Headings
- Skin
- RNA, Messenger
- Procollagen
- Male
- Humans
- Fibroblasts
- Dermatology & Venereal Diseases
- DNA
- Collagen
- Ascorbic Acid