Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.

Journal Article

In cultured human skin fibroblasts, ascorbic acid stimulates collagen production with no apparent change in the intracellular degradation of newly synthesized procollagen. To understand the basis for this effect, we measured the steady-state levels of type I and type III procollagen mRNAs in cells treated with ascorbic acid. A three- to fourfold increase in collagen synthesis was associated with a two- to threefold increase in the levels of mRNAs for both type I and type III procollagens. These effects of ascorbic acid are explained by a translational control linked either to procollagen gene transcription or mRNA degradation.

Full Text

Duke Authors

Cited Authors

  • Geesin, JC; Darr, D; Kaufman, R; Murad, S; Pinnell, SR

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 90 / 4

Start / End Page

  • 420 - 424

PubMed ID

  • 3351329

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

International Standard Serial Number (ISSN)

  • 0022-202X

Digital Object Identifier (DOI)

  • 10.1111/1523-1747.ep12460849

Language

  • eng