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Beta-adrenergic axis and heart disease.

Publication ,  Journal Article
Naga Prasad, SV; Nienaber, J; Rockman, HA
Published in: Trends Genet
October 2001

Beta-adrenergic receptors (beta-ARs) belong to a large family of G-protein-coupled receptors (GPCRs) that form the interface between the sympathetic nervous system and the cardiovascular system. The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine. In a number of cardiac diseases, however, the biology of beta-AR signaling pathways is altered dramatically. Here we discuss the role of beta-AR signaling in the normal and abnormal heart and how the use of genetically engineered mouse models has helped in our understanding of the pathophysiology of cardiac disease.

Duke Scholars

Published In

Trends Genet

DOI

ISSN

0168-9525

Publication Date

October 2001

Volume

17

Issue

10

Start / End Page

S44 / S49

Location

England

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Phosphatidylinositol 3-Kinases
  • Models, Cardiovascular
  • Mice, Knockout
  • Mice
  • Humans
  • Heart Failure
  • Heart Diseases
 

Citation

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Naga Prasad, S. V., Nienaber, J., & Rockman, H. A. (2001). Beta-adrenergic axis and heart disease. Trends Genet, 17(10), S44–S49. https://doi.org/10.1016/s0168-9525(01)02487-8
Naga Prasad, S. V., J. Nienaber, and H. A. Rockman. “Beta-adrenergic axis and heart disease.Trends Genet 17, no. 10 (October 2001): S44–49. https://doi.org/10.1016/s0168-9525(01)02487-8.
Naga Prasad SV, Nienaber J, Rockman HA. Beta-adrenergic axis and heart disease. Trends Genet. 2001 Oct;17(10):S44–9.
Naga Prasad, S. V., et al. “Beta-adrenergic axis and heart disease.Trends Genet, vol. 17, no. 10, Oct. 2001, pp. S44–49. Pubmed, doi:10.1016/s0168-9525(01)02487-8.
Naga Prasad SV, Nienaber J, Rockman HA. Beta-adrenergic axis and heart disease. Trends Genet. 2001 Oct;17(10):S44–S49.
Journal cover image

Published In

Trends Genet

DOI

ISSN

0168-9525

Publication Date

October 2001

Volume

17

Issue

10

Start / End Page

S44 / S49

Location

England

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Phosphatidylinositol 3-Kinases
  • Models, Cardiovascular
  • Mice, Knockout
  • Mice
  • Humans
  • Heart Failure
  • Heart Diseases