Beta-adrenergic axis and heart disease.

Journal Article (Review)

Beta-adrenergic receptors (beta-ARs) belong to a large family of G-protein-coupled receptors (GPCRs) that form the interface between the sympathetic nervous system and the cardiovascular system. The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine. In a number of cardiac diseases, however, the biology of beta-AR signaling pathways is altered dramatically. Here we discuss the role of beta-AR signaling in the normal and abnormal heart and how the use of genetically engineered mouse models has helped in our understanding of the pathophysiology of cardiac disease.

Full Text

Duke Authors

Cited Authors

  • Naga Prasad, SV; Nienaber, J; Rockman, HA

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • S44 - S49

PubMed ID

  • 11585676

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/s0168-9525(01)02487-8

Language

  • eng