Beta-adrenergic axis and heart disease.
Publication
, Journal Article
Naga Prasad, SV; Nienaber, J; Rockman, HA
Published in: Trends Genet
October 2001
Beta-adrenergic receptors (beta-ARs) belong to a large family of G-protein-coupled receptors (GPCRs) that form the interface between the sympathetic nervous system and the cardiovascular system. The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine. In a number of cardiac diseases, however, the biology of beta-AR signaling pathways is altered dramatically. Here we discuss the role of beta-AR signaling in the normal and abnormal heart and how the use of genetically engineered mouse models has helped in our understanding of the pathophysiology of cardiac disease.
Duke Scholars
Published In
Trends Genet
DOI
ISSN
0168-9525
Publication Date
October 2001
Volume
17
Issue
10
Start / End Page
S44 / S49
Location
England
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Receptors, Adrenergic, beta
- Phosphatidylinositol 3-Kinases
- Models, Cardiovascular
- Mice, Knockout
- Mice
- Humans
- Heart Failure
- Heart Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Naga Prasad, S. V., Nienaber, J., & Rockman, H. A. (2001). Beta-adrenergic axis and heart disease. Trends Genet, 17(10), S44–S49. https://doi.org/10.1016/s0168-9525(01)02487-8
Naga Prasad, S. V., J. Nienaber, and H. A. Rockman. “Beta-adrenergic axis and heart disease.” Trends Genet 17, no. 10 (October 2001): S44–49. https://doi.org/10.1016/s0168-9525(01)02487-8.
Naga Prasad SV, Nienaber J, Rockman HA. Beta-adrenergic axis and heart disease. Trends Genet. 2001 Oct;17(10):S44–9.
Naga Prasad, S. V., et al. “Beta-adrenergic axis and heart disease.” Trends Genet, vol. 17, no. 10, Oct. 2001, pp. S44–49. Pubmed, doi:10.1016/s0168-9525(01)02487-8.
Naga Prasad SV, Nienaber J, Rockman HA. Beta-adrenergic axis and heart disease. Trends Genet. 2001 Oct;17(10):S44–S49.
Published In
Trends Genet
DOI
ISSN
0168-9525
Publication Date
October 2001
Volume
17
Issue
10
Start / End Page
S44 / S49
Location
England
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Receptors, Adrenergic, beta
- Phosphatidylinositol 3-Kinases
- Models, Cardiovascular
- Mice, Knockout
- Mice
- Humans
- Heart Failure
- Heart Diseases