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How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.

Publication ,  Journal Article
Simon, SA; Liedtke, W
Published in: J Clin Invest
July 2008

Airway irritants cause a variety of lung pathologies. Two separate studies, the first recently reported in the JCI by Bessac et al. and the second reported by Andrè et al. in the current issue of the JCI (see the related article beginning on page 2574), have identified irritants that activate transient receptor potential cation channel, subfamily A, member 1 (TRPA1) receptors in airway sensory neurons, resulting in neurogenic inflammation and respiratory hypersensitivity. The identification of TRPA1 activation by toxicants from cigarette smoke and polluted air, such as crotonaldehyde, acrolein, and oxidizing agents such as hydrogen peroxide, is an important finding. These two studies enhance our understanding of how pollution and cigarette smoke can damage airway function and will hopefully pave the way for the development of rational alternative therapeutics for such airway injury.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

July 2008

Volume

118

Issue

7

Start / End Page

2383 / 2386

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • TRPA1 Cation Channel
  • Smoke
  • Respiratory Tract Diseases
  • Respiratory System
  • Respiratory Hypersensitivity
  • Oxidants
  • Nicotiana
  • Neurons, Afferent
 

Citation

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Simon, S. A., & Liedtke, W. (2008). How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. J Clin Invest, 118(7), 2383–2386. https://doi.org/10.1172/JCI36111
Simon, Sidney A., and Wolfgang Liedtke. “How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.J Clin Invest 118, no. 7 (July 2008): 2383–86. https://doi.org/10.1172/JCI36111.
Simon, Sidney A., and Wolfgang Liedtke. “How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.J Clin Invest, vol. 118, no. 7, July 2008, pp. 2383–86. Pubmed, doi:10.1172/JCI36111.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

July 2008

Volume

118

Issue

7

Start / End Page

2383 / 2386

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • TRPA1 Cation Channel
  • Smoke
  • Respiratory Tract Diseases
  • Respiratory System
  • Respiratory Hypersensitivity
  • Oxidants
  • Nicotiana
  • Neurons, Afferent