Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin.
Journal Article
To evaluate the effect of breathing 50 ppm carbon monoxide (CO) on exercise capacity in persons with anemia, 10 nonsmoking subjects with chronic anemia (mean hemoglobin 8.9 g%) were studied. No subject had heart or lung disease. By double-blind, randomized, crossover design, duration of fatigue-limited exercise after breathing CO and purified air for 1 hr was compared. Mean carboxyhemoglobin levels increased from 2.14 to 3.38% after breathing CO and decreased from 2.15 to 1.86% after breathing purified air, P less than 0.004. Mean exercise duration decreased from 270.8 to 221.0 sec after breathing CO in contrast to an increase from 267.9 to 271.6 sec after breathing purified air, P less than 0.0001. Hence, in the absence of clinical heart or lung disease, increasing carboxyhemoglobin concentrations aggravate exercise performance in nonsmokers with chronic anemia.
Full Text
Duke Authors
Cited Authors
- Aronow, WS; Schlueter, WJ; Williams, MA; Petratis, M; Sketch, MH
Published Date
- December 1984
Published In
Volume / Issue
- 35 / 2
Start / End Page
- 394 - 398
PubMed ID
- 6510389
Pubmed Central ID
- 6510389
International Standard Serial Number (ISSN)
- 0013-9351
Digital Object Identifier (DOI)
- 10.1016/0013-9351(84)90145-2
Language
- eng
Conference Location
- Netherlands