Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin.
To evaluate the effect of breathing 50 ppm carbon monoxide (CO) on exercise capacity in persons with anemia, 10 nonsmoking subjects with chronic anemia (mean hemoglobin 8.9 g%) were studied. No subject had heart or lung disease. By double-blind, randomized, crossover design, duration of fatigue-limited exercise after breathing CO and purified air for 1 hr was compared. Mean carboxyhemoglobin levels increased from 2.14 to 3.38% after breathing CO and decreased from 2.15 to 1.86% after breathing purified air, P less than 0.004. Mean exercise duration decreased from 270.8 to 221.0 sec after breathing CO in contrast to an increase from 267.9 to 271.6 sec after breathing purified air, P less than 0.0001. Hence, in the absence of clinical heart or lung disease, increasing carboxyhemoglobin concentrations aggravate exercise performance in nonsmokers with chronic anemia.
Duke Scholars
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- Toxicology
- Rest
- Random Allocation
- Physical Exertion
- Middle Aged
- Male
- Humans
- Heart Rate
- Female
- Double-Blind Method
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Toxicology
- Rest
- Random Allocation
- Physical Exertion
- Middle Aged
- Male
- Humans
- Heart Rate
- Female
- Double-Blind Method