Monocyte chemotactic mechanisms in patients with hypernephroma.

Journal Article (Journal Article)

Peripheral blood monocyte chemotaxis was evaluated in 15 patients with hypernephroma, 10 of whom were evaluated preoperatively and postoperatively. Five patients had a significantly reduced response preoperatively that returned to normal levels after radical nephrectomy. Animal experiments confirm the presence of a low-molecular weight (6,000--10,000 daltons) inhibitor, which is heat labile and functions at the macrophage level. Preliminary experiments indicate inhibitors of macrophage chemotaxis can be extracted from renal cell carcinomas. The importance of these inhibitors in modulating immune surveillance is discussed.

Full Text

Duke Authors

Cited Authors

  • Hemstreet, GP; Snyderman, R

Published Date

  • December 1, 1978

Published In

Start / End Page

  • 115 - 118

PubMed ID

  • 748765

International Standard Serial Number (ISSN)

  • 0083-1921


  • eng

Conference Location

  • United States