Cutaneous wound healing: recruiting developmental pathways for regeneration.

Published

Journal Article (Review)

Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals, repaired skin is not identical to intact uninjured skin, however, and this disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development. Improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for wound healing complications. Here we focus on the roles of several key developmental signaling pathways (Wnt/β-catenin, TGF-β, Hedgehog, Notch) in mammalian cutaneous wound repair, and compare this to their function in skin development. We discuss the varying responses to cutaneous injury across the taxa, ranging from complete regeneration to scar tissue formation. Finally, we outline how research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.

Full Text

Duke Authors

Cited Authors

  • Bielefeld, KA; Amini-Nik, S; Alman, BA

Published Date

  • June 2013

Published In

Volume / Issue

  • 70 / 12

Start / End Page

  • 2059 - 2081

PubMed ID

  • 23052205

Pubmed Central ID

  • 23052205

Electronic International Standard Serial Number (EISSN)

  • 1420-9071

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-012-1152-9

Language

  • eng