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The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity.

Publication ,  Journal Article
Fattah, A; Cypel, T; Donner, EJ; Wang, F; Alman, BA; Zuker, RM
Published in: Am J Transplant
December 2011

Vascularized composite allotransplantation as a viable reconstructive option is gaining recognition and new cases are being reported with increasing frequency including hand, face and laryngeal transplantation. However, only one successful complete lower limb transplantation has been reported to date, in which a functioning limb from one ischiopagus twin with a lethal cardiac anomaly was transplanted to the other. Six years later, the patient is mobilizing well and engaging in sporting activities with her peers in a mainstream school. Clinical evaluation of motor and sensory modalities demonstrated a good functional result. Quality of life was assessed using the short form-36 health survey and lower extremity functional scale disclosing a high level of social and physical capacity. Functional magnetic resonance imaging was performed and showed cortical integration of the limb; the implications of cortical plasticity and vascularized composite allotransplantation for the correction of congenital limb anomalies are presented.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2011

Volume

11

Issue

12

Start / End Page

2762 / 2767

Location

United States

Related Subject Headings

  • Twins, Conjoined
  • Surgery
  • Quality of Life
  • Motor Cortex
  • Magnetic Resonance Imaging
  • Lower Extremity
  • Leg Bones
  • Infant, Newborn
  • Humans
  • Heart Diseases
 

Citation

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Fattah, A., Cypel, T., Donner, E. J., Wang, F., Alman, B. A., & Zuker, R. M. (2011). The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity. Am J Transplant, 11(12), 2762–2767. https://doi.org/10.1111/j.1600-6143.2011.03782.x
Fattah, A., T. Cypel, E. J. Donner, F. Wang, B. A. Alman, and R. M. Zuker. “The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity.Am J Transplant 11, no. 12 (December 2011): 2762–67. https://doi.org/10.1111/j.1600-6143.2011.03782.x.
Fattah A, Cypel T, Donner EJ, Wang F, Alman BA, Zuker RM. The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity. Am J Transplant. 2011 Dec;11(12):2762–7.
Fattah, A., et al. “The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity.Am J Transplant, vol. 11, no. 12, Dec. 2011, pp. 2762–67. Pubmed, doi:10.1111/j.1600-6143.2011.03782.x.
Fattah A, Cypel T, Donner EJ, Wang F, Alman BA, Zuker RM. The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity. Am J Transplant. 2011 Dec;11(12):2762–2767.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2011

Volume

11

Issue

12

Start / End Page

2762 / 2767

Location

United States

Related Subject Headings

  • Twins, Conjoined
  • Surgery
  • Quality of Life
  • Motor Cortex
  • Magnetic Resonance Imaging
  • Lower Extremity
  • Leg Bones
  • Infant, Newborn
  • Humans
  • Heart Diseases