Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.

Journal Article (Journal Article;Review)

As a group, cartilage tumours are the most common primary bone lesions. They range from benign lesions, such as enchondromas and osteochondromas, to malignant chondrosarcoma. The benign lesions result from the deregulation of the hedgehog signalling pathway, which is involved in normal bone development. These lesions can be the precursors of malignant chondrosarcomas, which are notoriously resistant to conventional chemotherapy and radiotherapy. Cytogenetic studies and mouse models are beginning to identify genes and signalling pathways that have roles in tumour progression, such as hedgehog, p53, insulin-like growth factor, cyclin-dependent kinase 4, hypoxia-inducible factor, matrix metalloproteinases, SRC and AKT, suggesting potential new therapeutic approaches.

Full Text

Duke Authors

Cited Authors

  • Bovée, JVMG; Hogendoorn, PCW; Wunder, JS; Alman, BA

Published Date

  • July 2010

Published In

Volume / Issue

  • 10 / 7

Start / End Page

  • 481 - 488

PubMed ID

  • 20535132

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/nrc2869


  • eng

Conference Location

  • England