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Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.

Publication ,  Journal Article
Bovée, JVMG; Hogendoorn, PCW; Wunder, JS; Alman, BA
Published in: Nat Rev Cancer
July 2010

As a group, cartilage tumours are the most common primary bone lesions. They range from benign lesions, such as enchondromas and osteochondromas, to malignant chondrosarcoma. The benign lesions result from the deregulation of the hedgehog signalling pathway, which is involved in normal bone development. These lesions can be the precursors of malignant chondrosarcomas, which are notoriously resistant to conventional chemotherapy and radiotherapy. Cytogenetic studies and mouse models are beginning to identify genes and signalling pathways that have roles in tumour progression, such as hedgehog, p53, insulin-like growth factor, cyclin-dependent kinase 4, hypoxia-inducible factor, matrix metalloproteinases, SRC and AKT, suggesting potential new therapeutic approaches.

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Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

July 2010

Volume

10

Issue

7

Start / End Page

481 / 488

Location

England

Related Subject Headings

  • Pathology, Molecular
  • Osteochondroma
  • Oncology & Carcinogenesis
  • Mice
  • Humans
  • Gene Expression Regulation
  • Chondrosarcoma
  • Cartilage
  • Bone Neoplasms
  • Bone Development
 

Citation

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Bovée, J. V. M. G., Hogendoorn, P. C. W., Wunder, J. S., & Alman, B. A. (2010). Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer, 10(7), 481–488. https://doi.org/10.1038/nrc2869
Bovée, Judith V. M. G., Pancras C. W. Hogendoorn, Jay S. Wunder, and Benjamin A. Alman. “Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.Nat Rev Cancer 10, no. 7 (July 2010): 481–88. https://doi.org/10.1038/nrc2869.
Bovée JVMG, Hogendoorn PCW, Wunder JS, Alman BA. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010 Jul;10(7):481–8.
Bovée, Judith V. M. G., et al. “Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.Nat Rev Cancer, vol. 10, no. 7, July 2010, pp. 481–88. Pubmed, doi:10.1038/nrc2869.
Bovée JVMG, Hogendoorn PCW, Wunder JS, Alman BA. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010 Jul;10(7):481–488.

Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

July 2010

Volume

10

Issue

7

Start / End Page

481 / 488

Location

England

Related Subject Headings

  • Pathology, Molecular
  • Osteochondroma
  • Oncology & Carcinogenesis
  • Mice
  • Humans
  • Gene Expression Regulation
  • Chondrosarcoma
  • Cartilage
  • Bone Neoplasms
  • Bone Development