Beta-catenin in the race to fracture repair: in it to Wnt.

Journal Article (Journal Article;Review)

The Wnt/beta-catenin pathway regulates multiple biological events during embryonic development, including bone formation. Fracture repair recapitulates some of the processes of normal bone development, such as the formation of bone from a cartilaginous template, and many cell-signaling pathways that underlie bone development are activated during the repair process. The Wnt/beta-catenin signaling pathway is activated during fracture repair, and dysregulation of this pathway alters the normal bone-healing response. In early pluripotent mesenchymal stem cells, Wnt/beta-catenin signaling needs to be precisely regulated to facilitate the differentiation of osteoblasts; by contrast, beta-catenin is not needed for chondrocyte differentiation. Once mesenchymal stem cells are committed to the osteoblast lineage, activation of Wnt/beta-catenin signaling enhances bone formation. This activity suggests that the Wnt/beta-catenin pathway is a therapeutic target during bone repair. Indeed, treatments that activate Wnt/beta-catenin signaling, such as lithium, increase bone density and also enhance healing.

Full Text

Duke Authors

Cited Authors

  • Silkstone, D; Hong, H; Alman, BA

Published Date

  • August 2008

Published In

Volume / Issue

  • 4 / 8

Start / End Page

  • 413 - 419

PubMed ID

  • 18560386

Electronic International Standard Serial Number (EISSN)

  • 1745-8390

Digital Object Identifier (DOI)

  • 10.1038/ncprheum0838


  • eng

Conference Location

  • United States