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NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.

Publication ,  Journal Article
Yu, C; Le, A-T; Yeger, H; Perbal, B; Alman, BA
Published in: J Pathol
December 2003

Growth plate chondrocytes undergo a coordinated differentiation process resulting in terminal differentiation and new bone formation. Enchondromas are pre-malignant, benign cartilaginous lesions that arise from growth plate chondrocytes that fail to undergo terminal differentiation. NOV (nephroblastoma overexpressed) is a member of the CCN family of proteins, which share a common multi-modular organization. While the role of NOV in chondrocyte development and cartilage neoplasia is not known, other CCN family members play a role in chondrocyte differentiation, or are differentially regulated in cartilage neoplasia. In embryonic murine growth plates, NOV was expressed in pre-hypertrophic and early hypertrophic chondrocytes. PTHrP treatment (which inhibits terminal differentiation) decreased NOV expression in murine femurs maintained in organ culture, and decreased the activity of a NOV reporter construct in vitro. Expression of the CCN family members NOV, CTGF, CYR61, and WISP-1 was examined in 15 chondrosarcomas of various grades and in three enchondromas. Expression of all of the family members was lower in the higher-grade tumours. As identification of the grade of cartilage neoplasia can sometimes be difficult using histology alone, the level of expression of CCN family members could be a useful adjunct in the determination of tumour grade.

Duke Scholars

Published In

J Pathol

DOI

ISSN

0022-3417

Publication Date

December 2003

Volume

201

Issue

4

Start / End Page

609 / 615

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Pathology
  • Parathyroid Hormone-Related Protein
  • Organ Culture Techniques
  • Oncogene Proteins
  • Nephroblastoma Overexpressed Protein
  • Mitogens
  • Mice, Inbred Strains
 

Citation

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MLA
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Yu, C., Le, A.-T., Yeger, H., Perbal, B., & Alman, B. A. (2003). NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol, 201(4), 609–615. https://doi.org/10.1002/path.1468
Yu, Chunying, Anh-Thy Le, Herman Yeger, Bernard Perbal, and Benjamin A. Alman. “NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.J Pathol 201, no. 4 (December 2003): 609–15. https://doi.org/10.1002/path.1468.
Yu C, Le A-T, Yeger H, Perbal B, Alman BA. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol. 2003 Dec;201(4):609–15.
Yu, Chunying, et al. “NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.J Pathol, vol. 201, no. 4, Dec. 2003, pp. 609–15. Pubmed, doi:10.1002/path.1468.
Yu C, Le A-T, Yeger H, Perbal B, Alman BA. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol. 2003 Dec;201(4):609–615.
Journal cover image

Published In

J Pathol

DOI

ISSN

0022-3417

Publication Date

December 2003

Volume

201

Issue

4

Start / End Page

609 / 615

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Pathology
  • Parathyroid Hormone-Related Protein
  • Organ Culture Techniques
  • Oncogene Proteins
  • Nephroblastoma Overexpressed Protein
  • Mitogens
  • Mice, Inbred Strains