NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.

Published

Journal Article

Growth plate chondrocytes undergo a coordinated differentiation process resulting in terminal differentiation and new bone formation. Enchondromas are pre-malignant, benign cartilaginous lesions that arise from growth plate chondrocytes that fail to undergo terminal differentiation. NOV (nephroblastoma overexpressed) is a member of the CCN family of proteins, which share a common multi-modular organization. While the role of NOV in chondrocyte development and cartilage neoplasia is not known, other CCN family members play a role in chondrocyte differentiation, or are differentially regulated in cartilage neoplasia. In embryonic murine growth plates, NOV was expressed in pre-hypertrophic and early hypertrophic chondrocytes. PTHrP treatment (which inhibits terminal differentiation) decreased NOV expression in murine femurs maintained in organ culture, and decreased the activity of a NOV reporter construct in vitro. Expression of the CCN family members NOV, CTGF, CYR61, and WISP-1 was examined in 15 chondrosarcomas of various grades and in three enchondromas. Expression of all of the family members was lower in the higher-grade tumours. As identification of the grade of cartilage neoplasia can sometimes be difficult using histology alone, the level of expression of CCN family members could be a useful adjunct in the determination of tumour grade.

Full Text

Duke Authors

Cited Authors

  • Yu, C; Le, A-T; Yeger, H; Perbal, B; Alman, BA

Published Date

  • December 2003

Published In

Volume / Issue

  • 201 / 4

Start / End Page

  • 609 - 615

PubMed ID

  • 14648665

Pubmed Central ID

  • 14648665

Electronic International Standard Serial Number (EISSN)

  • 1096-9896

International Standard Serial Number (ISSN)

  • 0022-3417

Digital Object Identifier (DOI)

  • 10.1002/path.1468

Language

  • eng