Eosinophilic granuloma. A different behaviour in children than in adults.

Journal Article (Journal Article)

Localised Langerhans-cell histiocytosis of bone (eosinophilic granuloma) is a benign tumour-like condition with a variable clinical course. Different forms of treatment have been reported to give satisfactory results. However, previous series all contain patients with a wide age range. Our aim was to investigate the effect of skeletal maturity on the rate of recurrence of isolated eosinophilic granuloma of bone excluding those arising in the spine. We followed up 32 patients with an isolated eosinophilic granuloma for a mean of five years; 17 were skeletally immature. No recurrences were noted in the skeletally immature group even after biopsy alone. By contrast, four of 13 skeletally mature patients had a recurrence and required further surgery. This suggests that eosinophilic granuloma has a low rate of recurrence in skeletally immature patients.

Full Text

Duke Authors

Cited Authors

  • Plasschaert, F; Craig, C; Bell, R; Cole, WG; Wunder, JS; Alman, BA

Published Date

  • August 2002

Published In

Volume / Issue

  • 84 / 6

Start / End Page

  • 870 - 872

PubMed ID

  • 12211681

International Standard Serial Number (ISSN)

  • 0301-620X

Digital Object Identifier (DOI)

  • 10.1302/0301-620x.84b6.12585


  • eng

Conference Location

  • England