Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells.

Published

Journal Article

Repeated seizures, whether induced by kindling or electroshock, result in increased numbers of benzodiazepine receptors in hippocampal formation membranes. We sought to determine the cellular constituents containing the receptor increases. Binding studies of microdissected samples localized the receptor increases to fascia dentata. [3H]Flunitrazepam autoradiographic studies showed increases of silver grain density over the granule cell and molecular layers of fascia dentata but not in other regions of hippocampal formation. Destruction of granule cells by colchicine or neonatal x-irradiation was associated with marked decrease of benzodiazepine receptor binding. Together, these results provide evidence for localization of the receptor increases to the somata and dendritic tree of the granule cells. We suggest that this cellular localization may provide a clue to the network of altered neural circuitry underlying amygdala kindling.

Full Text

Duke Authors

Cited Authors

  • Valdes, F; Dasheiff, RM; Birmingham, F; Crutcher, KA; McNamara, JO

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 79 / 1

Start / End Page

  • 193 - 197

PubMed ID

  • 6275387

Pubmed Central ID

  • 6275387

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.79.1.193

Language

  • eng

Conference Location

  • United States