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Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study.

Publication ,  Journal Article
Tantry, US; Bliden, KP; Suarez, TA; Kreutz, RP; Dichiara, J; Gurbel, PA
Published in: Platelets
2010

The objective of the study was to determine the relation of platelet reactivity, hypercoagulability and inflammation in various stages of coronary artery disease acuity (CAD). Thrombin-induced platelet-fibrin clot strength (MA), time to initial platelet-fibrin clot formation (R), C-reactive protein (CRP), prothrombotic factors, activated GPIIb/IIIa receptor expression and other biomarkers were studied in patients with asymptomatic stable CAD (AS), in patients undergoing PCI for stable (SA) and unstable angina (UA). MA and R were measured by thrombelastography, GPIIb/IIIa expression by flow cytometry and all other markers by fluorokine multianalyte profiling assays. An overall increase in all measurements from a clinically stable to an unstable disease state was observed. There was a distinct stepwise increment in MA [AS vs. SA (p = 0.02), SA vs. UA (p = 0.02) and AS vs. UA (p < 0.001)]. MA exhibited the strongest correlation with other prothrombotic markers (p < or = 0.02), with CRP (p < 0.001) at all levels of CAD acuity. A distinct pathophysiological state of heightened platelet function, hypercoagulability and inflammation marks the presence of unstable cardiovascular disease requiring intervention. Further studies are required to investigate the primary mechanisms linking the above processes associated with a prothrombotic state resulting in clinical destabilization of the disease.

Duke Scholars

Published In

Platelets

DOI

EISSN

1369-1635

Publication Date

2010

Volume

21

Issue

5

Start / End Page

360 / 367

Location

England

Related Subject Headings

  • Thrombophilia
  • Thrombelastography
  • Male
  • Inflammation
  • Humans
  • Flow Cytometry
  • Fibrin
  • Female
  • Disease Progression
  • Coronary Artery Disease
 

Citation

APA
Chicago
ICMJE
MLA
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Tantry, U. S., Bliden, K. P., Suarez, T. A., Kreutz, R. P., Dichiara, J., & Gurbel, P. A. (2010). Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study. Platelets, 21(5), 360–367. https://doi.org/10.3109/09537100903548903
Tantry, Udaya S., Kevin P. Bliden, Thomas A. Suarez, Rolf P. Kreutz, Joseph Dichiara, and Paul A. Gurbel. “Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study.Platelets 21, no. 5 (2010): 360–67. https://doi.org/10.3109/09537100903548903.
Tantry US, Bliden KP, Suarez TA, Kreutz RP, Dichiara J, Gurbel PA. Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study. Platelets. 2010;21(5):360–7.
Tantry, Udaya S., et al. “Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study.Platelets, vol. 21, no. 5, 2010, pp. 360–67. Pubmed, doi:10.3109/09537100903548903.
Tantry US, Bliden KP, Suarez TA, Kreutz RP, Dichiara J, Gurbel PA. Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study. Platelets. 2010;21(5):360–367.

Published In

Platelets

DOI

EISSN

1369-1635

Publication Date

2010

Volume

21

Issue

5

Start / End Page

360 / 367

Location

England

Related Subject Headings

  • Thrombophilia
  • Thrombelastography
  • Male
  • Inflammation
  • Humans
  • Flow Cytometry
  • Fibrin
  • Female
  • Disease Progression
  • Coronary Artery Disease