Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients.

Published

Journal Article

Selected aspirin treated patients may exhibit high platelet reactivity to agonists other than arachidonic acid. This study aimed to determine whether the VerifyNow identifies generalized high platelet reactivity supported by correlations with other established methods that stimulate platelets with various agonists. Stable outpatients with coronary artery disease (n = 110) were treated with aspirin in a two 3 x 3 Latin square design (81, 162 and 325 mg/day for 4 weeks each). VerifyNow (arachidonic acid (AA) cartridge); light transmittance aggregometry; thrombelastography; PFA-100; flow cytometry; PlateletWorks; and urinary 11- dehydro thromboxane levels were measured. Multianalyte profiling measured fibrinogen and von Willebrand factor (vWF). Patients with >or=550 ARU by VerifyNow had increased 5 mM AA-, 5 microM ADP-, and 2 microg/mL collagen-induced platelet aggregation compared to patients with <550 ARU (p

Full Text

Duke Authors

Cited Authors

  • Dichiara, J; Bliden, KP; Tantry, US; Chaganti, SK; Kreutz, RP; Gesheff, TB; Kreutz, Y; Gurbel, PA

Published Date

  • September 2007

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 414 - 423

PubMed ID

  • 17763150

Pubmed Central ID

  • 17763150

Electronic International Standard Serial Number (EISSN)

  • 1369-1635

International Standard Serial Number (ISSN)

  • 0953-7104

Digital Object Identifier (DOI)

  • 10.1080/09537100701206824

Language

  • eng