Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients.
Selected aspirin treated patients may exhibit high platelet reactivity to agonists other than arachidonic acid. This study aimed to determine whether the VerifyNow identifies generalized high platelet reactivity supported by correlations with other established methods that stimulate platelets with various agonists. Stable outpatients with coronary artery disease (n = 110) were treated with aspirin in a two 3 x 3 Latin square design (81, 162 and 325 mg/day for 4 weeks each). VerifyNow (arachidonic acid (AA) cartridge); light transmittance aggregometry; thrombelastography; PFA-100; flow cytometry; PlateletWorks; and urinary 11- dehydro thromboxane levels were measured. Multianalyte profiling measured fibrinogen and von Willebrand factor (vWF). Patients with >or=550 ARU by VerifyNow had increased 5 mM AA-, 5 microM ADP-, and 2 microg/mL collagen-induced platelet aggregation compared to patients with <550 ARU (p
Duke Scholars
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Related Subject Headings
- von Willebrand Factor
- Platelet Function Tests
- Platelet Aggregation
- Middle Aged
- Male
- Humans
- Fibrinogen
- Female
- Double-Blind Method
- Cross-Over Studies
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- von Willebrand Factor
- Platelet Function Tests
- Platelet Aggregation
- Middle Aged
- Male
- Humans
- Fibrinogen
- Female
- Double-Blind Method
- Cross-Over Studies