Aspirin and clopidogrel resistance: consideration and management.

Journal Article (Journal Article;Review)

The efficacy with aspirin and clopidogrel treatment has been demonstrated in various clinical trials. Laboratory evaluation of platelet response in recent studies revealed that a distinctive response variability and nonresponsiveness/resistance in selected patients were associated with these antiplatelet agents. Moreover, some studies have correlated this nonresponsiveness/resistance phenomenon to the occurrence of thrombotic events. At this time there are no uniformly established methods to quantify exvivo platelet reactivity after clopidogrel and aspirin treatment of the extent of platelet inhibition by clopidogrel and aspirin. Therefore, specific treatment recommendations for patients exhibiting high platelet reactivity or poor platelet inhibition during clopidogrel or aspirin therapy are not established. A higher aspirin dose and strict compliance to therapy may overcome the occurrence of "aspirin resistance" in selected patients. A higher clopidogrel dose may be considered in patients exhibiting clopidogrel nonresponsiveness.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Tantry, US

Published Date

  • October 2006

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 439 - 448

PubMed ID

  • 17020569

International Standard Serial Number (ISSN)

  • 0896-4327

Digital Object Identifier (DOI)

  • 10.1111/j.1540-8183.2006.00181.x


  • eng

Conference Location

  • United States