Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.
The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.
Wang, H; Gomez, JA; Klein, S; Zhang, Z; Seidler, B; Yang, Y; Schmeckpeper, J; Zhang, L; Muramoto, GG; Chute, J; Pratt, RE; Saur, D; Mirotsou, M; Dzau, VJ
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