Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.

Journal Article

The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.

Full Text

Duke Authors

Cited Authors

  • Wang, H; Gomez, JA; Klein, S; Zhang, Z; Seidler, B; Yang, Y; Schmeckpeper, J; Zhang, L; Muramoto, GG; Chute, J; Pratt, RE; Saur, D; Mirotsou, M; Dzau, VJ

Published Date

  • July 2013

Published In

Volume / Issue

  • 24 / 8

Start / End Page

  • 1263 - 1273

PubMed ID

  • 23744888

Electronic International Standard Serial Number (EISSN)

  • 1533-3450

Digital Object Identifier (DOI)

  • 10.1681/ASN.2012060596

Language

  • eng

Conference Location

  • United States